Role of Dietary Nutrients in the Modulation of Gut Microbiota: A Narrative Review

Yang, Qi; Liang, Qi; Balakrishnan, Biju; Belobrajdic, Damien P.; Qian, Feng; Zhang, Wei

doi:10.3390/nu12020381

Cited by 341 publications

(329 citation statements)

References 256 publications

(343 reference statements)

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“…In general, the group of gut microbes associated with a good health outcome are identified as “potential beneficial bacteria,” 33 such as short‐chain fatty acid (SCFA)‐producing bacteria ( Bacteroides, Faecalibacterium, Phascolarctobacterium, Roseburia, Bifidobacterium, Blautia, etc) 34‐36 . Those could potentially lead to development or progression of noncommunicable diseases are identified as “potential detrimental microbes,” 33 such as enteric pathogens and opportunistic pathogens ( Escherichia‐Shigella , Klebsiella , Enterococcus , Streptococcus , etc) 37‐39 …”

Section: Methodsmentioning

confidence: 99%

Long‐term changes in the gut microbiota after 14‐day bismuth quadruple therapy in penicillin‐allergic children

Zhou

Miao

et al. 2020

Helicobacter

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Background Penicillin‐allergic children who are infected with Helicobacter pylori constitute a relatively common subgroup. We aimed to study the short‐term and long‐term effects of bismuth quadruple therapy on gut microbiota in penicillin‐allergic children. Methods We prospectively recruited treatment‐naive children with H pylori infection and H pylori‐negative asymptomatic children as healthy controls. Patients received 14‐day bismuth quadruple therapy consisting of omeprazole, clarithromycin, metronidazole, and bismuth. Fecal samples were collected at weeks 0, 2, 6, and 52. Alterations in the gut microbiota were analyzed by 16S rRNA gene sequencing. Results Twenty‐two subjects (14 gastritis patients, 8 duodenal ulcer patients) and 23 controls participated in this study. At week 2, alpha diversity was reduced in both gastritis (P < .05) and ulcer (except P = .16 with Chao 1 index) patients compared with baseline. Some changes persisted at week 6, and all were restored at week 52. Beta diversity was significantly altered 2 weeks after treatment in the gastritis and duodenal ulcer groups (P = .001, P = .002, respectively) and restored at weeks 6 and 52. The mean relative abundance of Bacteroidetes (P < .001, P = .005, respectively) decreased and that of Proteobacteria increased (P < .001, P = .03, respectively). All alterations recovered at week 6 and 52. In both the gastritis and ulcer groups at week 2, some beneficial bacteria were decreased including Bacteroides (P < .001 and P = .003), Faecalibacterium (P < .001 and P = .02), Phascolarctobacterium (P = .002 and P = .004), Roseburia ( P < .001 and P = .13), Bifidobacterium (P = .08 and P = .04), and Blautia (P < .001 and P = .002). Some detrimental bacteria were increased including Escherichia‐Shigella (P < .001 and P = .19), Klebsiella (P < .001, and P = .09), Enterococcus (P < .001 and P = .007), and Streptococcus (P = .002 and P = .004). The changes returned to almost the pre‐eradication level 1 year after therapy. Conclusion Bismuth quadruple therapy causes short‐term dysbiosis of the gut microbiota. Most changes recovered 1‐year post‐eradication, indicating the long‐term safety of H pylori therapy.

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Section: Methodsmentioning

confidence: 99%

Long‐term changes in the gut microbiota after 14‐day bismuth quadruple therapy in penicillin‐allergic children

Zhou

Miao

et al. 2020

Helicobacter

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“…With the consumption of trimethylamine-containing meat products, such as phosphatidylcholine, choline, and L-carnitine, the microbiota produces trimethylamine N-oxide (TMAO). This metabolite together with increased levels of L-carnitine, choline, and phosphatidylcholine are direct cardiovascular risk factors [127][128][129]. In addition, other nutrients in the diet can modulate intestinal microbes for cardiovascular disease.…”

Section: Diet Nutrients and Microbiota In Cardiovascular Diseasesmentioning

confidence: 99%

Non-Systematic Review of Diet and Nutritional Risk Factors of Cardiovascular Disease in Obesity

et al. 2020

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Although cardiovascular disease and its risk factors have been widely studied and new methods of diagnosis and treatment have been developed and implemented, the morbidity and mortality levels are still rising-cardiovascular disease is responsible for more than four million deaths each year in Europe alone. Even though nutrition is classified as one of the main and changeable risk factors, the quality of the diet in the majority of people does not follow the recommendations essential for prevention of obesity and cardiovascular disease. It demonstrates the need for better nutritional education in cardiovascular disease prevention and treatment, and the need to emphasize dietary components most relevant in cardiovascular disease. In our non-systematic review, we summarize the most recent knowledge about nutritional risk and prevention in cardiovascular disease and obesity.

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“…The diet is one of the main factors in uencing the microbiota and the cooccurrence patterns of the caecal bacterial community [1,3]. Speci cally, dietary fat intake can modulate gut microbiota [4,5]. It has been reported that some fatty acids (FA) and in particular medium-chain fatty acids (MCFA) act as bacteriostatic (growth inhibiting) or bactericidal (killing) molecules [6,7].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial effects of Black Soldier Fly and Yellow Mealworm fats and their impact on gut microbiota of growing rabbits

Dabbou

Ferrocino

Gasco

et al. 2020

Preprint

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Background The study aimed to evaluate the in vitro antimicrobial activities of two types of insect fats extracted from black soldier fly larvae (HI, Hermetia illucens L.) and yellow mealworm larvae (TM, Tenebrio molitor L.) and their effects as dietary replacement of soybean oil (S) on caecal fermentation pattern, and faecal and caecal microbiota in rabbits. Results A total of 120 weaned rabbits were randomly allotted to 3 dietary treatments (40 rabbits/group): a control diet (C diet) containing 1.5% of S and two experimental diets (HID and TMD) where S was totally substituted by HI or TM fats. Regarding the in vitro antimicrobial activities, HI and TM fats did not show any effects on Salmonella growth. Yersinia enterocolitica showed lower growth when challenged with insect fats than the controls. The insect fat supplementation in rabbit diets increased the contents of the caecal volatile fatty acids when compared to the control group. A metataxonomic approach was adopted to investigate the shift in the microbial composition as a function of the dietary insect fat supplementation. The microbiota did not show a clear separation as a function of the inclusion, even if a specific microbial signature was observed. Indeed, HI and TM fat supplementation enriched the presence of Akkermansia that was found to be correlated with NH3-N concentration. An increase in Ruminococcus, which can improve the immune response of the host, was also observed. Conclusions This study confirms the potential of HI and TM fats as antibacterial feed ingredients with a positive influence on the rabbit caecal microbiota, thus supporting the possibility of including HI and TM fats in rabbit diets.

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Role of Dietary Nutrients in the Modulation of Gut Microbiota: A Narrative Review

Cited by 341 publications

References 256 publications

Long‐term changes in the gut microbiota after 14‐day bismuth quadruple therapy in penicillin‐allergic children

Long‐term changes in the gut microbiota after 14‐day bismuth quadruple therapy in penicillin‐allergic children

Non-Systematic Review of Diet and Nutritional Risk Factors of Cardiovascular Disease in Obesity

Antimicrobial effects of Black Soldier Fly and Yellow Mealworm fats and their impact on gut microbiota of growing rabbits

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