2015
DOI: 10.1016/j.jns.2014.12.004
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Role of diffusion tensor imaging or magnetic resonance spectroscopy in the diagnosis and disability assessment of amyotrophic lateral sclerosis

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Cited by 15 publications
(14 citation statements)
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“…The DTI evaluation surprisingly evidenced bilateral impairment of CST diffusion metrics, with clear right-left asymmetry, pointing to a neurodegenerative etiology (15), which clinically appeared less likely at that time. Then, the marked reduction of NAA/Cho + Cr ratio in the MC shown by MRS further supported the hypothesis of UMN degeneration (6)(7)(8).…”
Section: Discussionsupporting
confidence: 60%
See 1 more Smart Citation
“…The DTI evaluation surprisingly evidenced bilateral impairment of CST diffusion metrics, with clear right-left asymmetry, pointing to a neurodegenerative etiology (15), which clinically appeared less likely at that time. Then, the marked reduction of NAA/Cho + Cr ratio in the MC shown by MRS further supported the hypothesis of UMN degeneration (6)(7)(8).…”
Section: Discussionsupporting
confidence: 60%
“…It may raise the suspect of a MND at the very beginning, especially if presenting in an insidious way, but it is essential to exclude other more likely diagnostic possibilities (i.e., lesional causes) and to consider the progression of the syndrome over time. The role of MR in confirming an extensive UMN involvement of possible degenerative etiology has been highlighted by previous works (6)(7)(8). Moreover, the evaluation of white matter abnormalities by diffusion tensor imaging (DTI) proved useful for distinguishing between ALS and PLS (9,10).…”
Section: Introductionmentioning
confidence: 98%
“…Reduction in neocortex volume, GM and WM volume and brain parenchymal fraction.GM volume reduction is most important in the motor cortex of the contralateral hemisphere of the limb of onset. ALSFRS is positively correlated with GM density in the left postcentral cortex and DPR is negatively correlated with GM density in the right precentral cortexZhu et al, [31, 87]22/22GM reduction in the right and left precentral cortex.Negative with DD, DPR and all other clinical parameters. GM grey matter, WM white matter, BA Brodman area, DD disease duration, DPR Disease progression rate, UMN upper motor neuron…”
Section: Resultsmentioning
confidence: 99%
“…NAA and Cr were correlated in left MCCorrelation between ins in MC and UMN disability, negative correlation between Naa in MC and UMN disability, higher Cho in sever UMN disability groupCervo et al, [90]84/28NAA/(Cho + Cr) was low in the MCNegativeFoerster et al, [95]10/9Low gamma aminobutyric acid in the MC but not in WMNegativeFoerster et al, [55]29/30NAA and gamma aminobutyric acid were low and ins was elevated in the left MCNegative correlation between gamma aminobutyric acid in MC and DD, correlation between Naa peak in MC and ALSFRS-RGovind et al, [92]38/70NAA was low and Cho was elevated in most parts of CST, and Cho/NAA was elevated in all parts of the CSTsNegative correlation between Cho/Naa in the left entire CST and forced vital capacity, negative correlation between Cho/Naa in the left CST and right and left finger tap rate, negative correlation between Cho/Naa in left MC and semiovale centrum and right finger tape or forced vital capacityHan et al, [85]15/15NAA/Cr peak was low in the MC and PLIC, Glu/Cr and Glu + Gln/Cr peaks were low in the MC and PLICNegative correlation between Glu + Gln/Cr with Norris scoreKalra et al, [88, 89]63/18NAA/Cho and NAA/Cr was low in the MC, and Cho/Cr was elevated in the MCRelation between decreased Naa/Cho in the MC and reduced survival.Kalra et al, [88, 89]17/15NAA/Ins, NAA/Cr and NAA/Cho were low in the MC, and Ins/Cr was elevated in the MCNegative (p ≤ 0.05)Liu et al, [87]19/13NAA/Cr was low in the MCNegativeLombardo et al, [79]32/19NAA/Cr was low and ins/Cr and Cho/Cr were elevated in the MC.Abnormalities were correlated with the El Escorial scorePohl et al, [91]70/48NAA, Pcr + Cr, NAA/Cho and NAA/(Pcr + Cr) were low in the MC. At 12 months, NAA/Cho was low and Cho/(Pcr + Cr) was elevatedNot availablePyra et al, [59]14/14NAA/Cho and NAA/Cr were low in the MC and corona radiata, and Cho/Cr was elevated in the MCCorrelation between Naa/Cho peak in MC and DD, negative correlation between Naa/Cho in MC and corona radiata and DPRRooney et al, [86]10/9NAA/(Cho + Cr) was low in the MC and CST but not in other regionsCorrelation between Naa/(Cho + Cr) in the MC and maximum finger tape rateStagg et al, [47]13/14…”
Section: Resultsmentioning
confidence: 99%
“…Increased Cho and Cho/Cr levels have been reported in people with ALS [15, 22–24] in some studies but not others [16, 21, 25, 26]. Elevated mI and mI/Cr have been detected in the motor cortex in people with ALS [15, 22, 27, 28] but not in early-stage ALS [29].…”
Section: Introductionmentioning
confidence: 99%