Role of diffusion‐weighted imaging in distinguishing thoracoabdominal neuroblastic tumours of various histological types and differentiation grades

Wen, Yang; Peng, Yun; Duan, Xiao Min; Zhang, Nan

doi:10.1111/1754-9485.12615

Cited by 11 publications

(8 citation statements)

References 17 publications

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“…In contrast, another study on 29 patients with neuroblastic tumours, including four GBN [10] reported no overlap. A recently published report on 25 children with thoracoabdominal neuroblastic tumours examined with DWI at 3 T further refined analysis and correlated ADC with various histological subtypes and differentiation grades [15]. The overall picture is that of a continuous spectrum of disease, rather than of discrete categories, both on the histopathological level and on diagnostic imaging.…”

Section: Discussionmentioning

confidence: 99%

Quantitative DWI predicts event-free survival in children with neuroblastic tumours: preliminary findings from a retrospective cohort study

et al. 2019

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BackgroundQuantitative diffusion-weighted imaging (DWI) probes into tissue microstructure in solid tumours. In this retrospective ethically approved study, we investigated DWI as a potential non-invasive predictor of tumour dignity and prognosis in paediatric patients with neuroblastic tumours.MethodsNineteen consecutive patients with neuroblastoma (NB, n = 15), ganglioneuroblastoma (GNB, n = 1) and ganglioneuroma (GN, n = 3) underwent 3-T magnetic resonance imaging at first diagnosis and after 3-month follow-up, following a protocol including DWI (b = 50 and 800 s/mm2) in addition to standard sequences. All DWI scans were analysed for tumour volume assessment and apparent diffusion coefficient (ADC) calculation. Correlation with tumour pathology and risk factors (bone-marrow metastases, MYCN-amplification and 1p-deletion), therapeutic regime (observation versus chemotherapy) and clinical follow-up was evaluated.ResultsAt baseline, mean ADC in NB was lower than in GNB/GN (0.76 vs. 1.47 × 10−3 mm2/s, p = 0.003). An ADC cutoff ≤ 1.05 identified malignant disease with 100.0% sensitivity (95% confidence interval [CI] 29.2–100.0%) and 93.8% specificity (95% CI 69.8–99.8%). Initial ADC was < 0.80 in all NB patients with eventual tumour relapse. During follow-up, tumour ADC values increased in the observation group (NB/GN) without relapse (p = 0.043). In eventually relapsing tumours, ADC values at follow-up tended to decrease further despite reduction in tumour volume.ConclusionsADC values at first presentation differed significantly between malignant and benign neuroblastic tumours. Low baseline ADC was predictive of tumour progression and relapse in NB patients. With therapy, increasing ADC values appeared to predict relapse-free survival, while a decreasing ADC during therapy was an indicator of poor prognosis.

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Section: Discussionmentioning

confidence: 99%

Quantitative DWI predicts event-free survival in children with neuroblastic tumours: preliminary findings from a retrospective cohort study

et al. 2019

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“…GN typically shows bright T2 signal and Low T1 signal with slow mild to moderate enhancement. While MRI was previously considered incapable of differentiating GN from malignant variants, recent studies evaluating the use of diffusion weighted imaging indicate that high apparent diffusion coefficient (ADC) values can reliably differentiate GN from neuroblastoma and ganglioneuroblastoma [12] , [13] – 14] . Ultimately histopathologic analysis is necessary for definitive diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging

Brock

Sharma

Villada

et al. 2021

Radiology Case Reports

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Ganglioneuromas (GN) are rare, mature tumors that arise in the posterior mediastinum or retroperitoneum from neural crest cells and present as slow growing masses in the pediatric population. While they are often found incidentally in unrelated diagnostic workup, they can become symptomatic due to their size and location. They typically demonstrate the nonspecific appearance of a solid mass without invasive or destructive features across different modalities. Such features are normally indicative of more aggressive neoplasms from similar cellular ancestry or an entirely different lineage. Here we present a case of mediastinal GN that on imaging was initially suggestive of an osteochondroma with malignant degeneration based on the presence of an exostosis associated with a large solid mass. Final pathology, however, revealed GN with involvement of the adjacent bone. While the final diagnosis was benign, it is important to recognize this pattern of exostosis with solid mass, especially since the overall survival rate of sarcomata is much worse than that of a classic GN.

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“…A second limitation is that the difference was not examined by histological subtypes, although the distribution of histological subtype was uneven in both groups. Differences in ADC values due to histological types have also been reported at other primary sites [21]. Finally, although the ADC value might be a useful indicator only in cases where an epithelial borderline or malignant tumor is suspected, benign tumors were excluded in this study.…”

Section: Discussionmentioning

confidence: 87%

Differentiation between stage I ovarian cancer and borderline epithelial ovarian tumor by apparent diffusion coefficient value

Masamoto¹,

Mekaru²,

Nakasone³

et al. 2018

Is It All Just an Akt - You’d Be SMAD to Believe It! Role of TGFβ1 in Oral Cancer Metastasis

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To clarify usefulness of apparent diffusion coefficient (ADC) value in the differential diagnosis of stage I malignant epithelial ovarian tumor (MOT) and borderline epithelial ovarian tumor (BOT), the ADC value of the solid portion or thickened wall of ovarian tumors was evaluated by a 1.5-T magnetic resonance imaging system in 18 cases of BOT and MOT. The median of average ADC value was 1.668 × 10 −3 mm 2 /s for BOT and 1.021 × 10 −3 mm 2 /s for MOT (p = 0.0005), and the median of minimum ADC value was 1.394 × 10 −3 mm 2 /s for BOT and 0.812× 10 −3 mm 2 /s for MOT (p = 0.0006), both of which were significantly lower in MOT than that in BOT. So the ADC value is useful and especially the minimum ADC value is useful in that it can easily measure the ROI so that it contains solid portion or thickened wall.

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Role of diffusion‐weighted imaging in distinguishing thoracoabdominal neuroblastic tumours of various histological types and differentiation grades

Abstract: ADC of DWI is highly valuable for discriminating thoracoabdominal neuroblastic tumours of different histological types and differentiation grades.

Cited by 11 publications

References 17 publications

Quantitative DWI predicts event-free survival in children with neuroblastic tumours: preliminary findings from a retrospective cohort study

Quantitative DWI predicts event-free survival in children with neuroblastic tumours: preliminary findings from a retrospective cohort study

Mediastinal ganglioneuroma with osseous invasion simulating malignant transformation of osteochondroma on CT imaging

Differentiation between stage I ovarian cancer and borderline epithelial ovarian tumor by apparent diffusion coefficient value

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