Role of diffusion-weighted magnetic resonance imaging in differentiation between the viable and necrotic parts of head and neck tumors

Razek, Ahmed Abdel Khalek Abdel; Megahed, Abdel Salam; Denewer, Adel; Motamed, Arash; Tawfik, Ahmed; Nada, Nadia

doi:10.1080/02841850701777390

Cited by 84 publications

(47 citation statements)

References 14 publications

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“…This can help to select the biopsy site from the solid part of the lymph nodes. Abdel Razek et al [20] reported that the mean ADC of the viable part (1.17±0.33×10 −3 mm 2 /s) was less than that of the necrotic part of the tumor (2.11±0.58×10 −3 mm 2 /s). Thus, ADC map can differentiate the viable from the necrotic part of head and neck tumors.…”

Section: Discussionmentioning

confidence: 96%

Role of diffusion-weighted MR imaging in cervical lymphadenopathy

et al. 2006

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The role of diffusion-weighted magnetic resonance imaging (MRI) for differentiation between various causes of cervical lymphadenopathy was evaluated. In a prospective study, 31 untreated patients (22 males and nine females, aged 5-70 years) with 87 cervical lymph nodes underwent diffusion-weighted MRI before performance of neck dissection (n=14), surgical biopsy (n=9) or core biopsy (n=8). Diffusion-weighted MR images were acquired with a b factor of 0 and 1,000 s/mm2 using single-shot echo-planar sequence. Apparent diffusion coefficient (ADC) maps were reconstructed for all patients. The signal intensity of the lymph nodes was assessed on images obtained at b=0 or 1,000 s/mm2 and from the ADC maps. The ADC value of lymph nodes was also calculated. On the ADC map, malignant nodes showed either low (n=52) or mixed (n=20) signal intensity and benign nodes revealed high (n=13) or low (n=2) signal intensity. The mean ADC value of metastatic (1.09+/-0.11x10(-3) mm2/s) and lymphomatous (0.97+/-0.27x10(-3) mm2/s) lymph nodes was significantly lower than that of benign (1.64+/-0.16x10(-3) mm2/s) cervical lymph nodes (P<0.04). When an ADC value of 1.38x10(-3) mm2/s was used as a threshold value for differentiating malignant from benign lymph nodes, the best results were obtained with an accuracy of 96%, sensitivity of 98%, specificity of 88%, positive predictive value of 98.5% and negative predictive value of 83.7%. The smallest detected lymph node was 0.9 cm. In conclusion, diffusion-weighted MRI with ADC mapping is a new promising technique that can differentiate malignant from benign lymph nodes and delineate the solid viable part of the lymph node for biopsy. This technique provides additional useful physiological and functional information regarding characterization of cervical lymph nodes.

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Section: Discussionmentioning

confidence: 96%

Role of diffusion-weighted MR imaging in cervical lymphadenopathy

et al. 2006

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“…With respect to the apparent diffusion coefficient (ADC) as a quantitative biomarker in the field of oncology, several investigators have reported promising results for the characterisation of malignancy as well as the prediction and monitoring of therapeutic responses [22][23][24][25][26][27][28][29]. However, the strength of evidence for the two key hypotheses that pretherapy ADC values may indicate the therapeutic outcome and that changes in ADC values predict clinical outcome is still moderate according to the extensive review by Patterson and coauthors [20].…”

Section: Introductionmentioning

confidence: 95%

Apparent diffusion coefficient for evaluating tumour response to neoadjuvant chemoradiation therapy for locally advanced rectal cancer

et al. 2010

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“…Wang et al 7 reported that a threshold ADC value of 1.22 ϫ 10 Ϫ3 mm 2 /s for differentiating benign and malignant tumors of the head and neck has 87% accuracy, 84% sensitivity, 91% specificity, 93% positive predictive value, and 78% negative predictive value. Abdel Razek et al 20 reported that the mean ADC value of the viable and necrotic part of the head and neck tumor are 1.17 Ϯ 0.33 ϫ 10 Ϫ3 mm 2 /s and 2.11 Ϯ 0.58 ϫ 10 Ϫ3 mm 2 /s, respectively. False-negative and false-positive results were seen in 5 (17%) of our cases.…”

Section: Fig 7 Posttreatment Changes After Surgery and Radiation Thementioning

confidence: 99%

Role of Diffusion-Weighted Echo-Planar MR Imaging in Differentiation of Residual or Recurrent Head and Neck Tumors and Posttreatment Changes

Razek¹,

Kandeel²,

Soliman³

et al. 2007

American Journal of Neuroradiology

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197

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Role of diffusion-weighted magnetic resonance imaging in differentiation between the viable and necrotic parts of head and neck tumors

Abstract: Creation of an ADC map is an excellent method for differentiation between the viable and necrotic parts of head and neck tumors. Thus, the ADC map can be used to select the best biopsy site and to detect tumor viability in post-treatment follow-up of patients after radiation therapy.

Cited by 84 publications

References 14 publications

Role of diffusion-weighted MR imaging in cervical lymphadenopathy

Role of diffusion-weighted MR imaging in cervical lymphadenopathy

Apparent diffusion coefficient for evaluating tumour response to neoadjuvant chemoradiation therapy for locally advanced rectal cancer

Role of Diffusion-Weighted Echo-Planar MR Imaging in Differentiation of Residual or Recurrent Head and Neck Tumors and Posttreatment Changes

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