Role of DNA damage and repair in radiation cancer therapy: a current update and a look to the future

Liu, Jingya; Bi, Kedong; Yang, Run; Li, Hongxia; Nikitaki, Zacharenia; Li, Chang

doi:10.1080/09553002.2020.1807641

Cited by 27 publications

(17 citation statements)

References 72 publications

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“…Ionizing radiation directly damages DNA by inducing both single- and double-strand breaks, with the latter being the most deleterious. 9 Indirect DNA damage can also occur via radiolysis of water molecules which produces reactive oxygen species, in turn causing single-strand breaks and other alterations to DNA 10 , 11 ( Figure 1 ). Imperfect repair of this damage can result in point mutations, gene fusions, large-scale deletions or translocations, all with the potential to activate oncogenes or inactivate tumor-suppressor genes.…”

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confidence: 99%

“…These changes are often associated with ongoing genomic instability and thus an increased risk of developing cancer. 9 , 11 , 12 In the case of radiation-induced second malignancies, genomic instability is thought to persist for multiple generations of cells over many years prior to oncogenic transformation, resulting in a significant latency period between the exposure event and the development of radiation-induced cancer. 12 …”

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confidence: 99%

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Defining the molecular features of radiation-induced glioma: A systematic review and meta-analysis

Whitehouse

Howlett

Federico

et al. 2021

Neuro-Oncology Advances

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Background Cranial radiation therapy is essential in treating many pediatric cancers, especially brain tumors, however its use comes with the risk of developing second malignancies. Cranial radiation-induced gliomas (RIGs) are aggressive high-grade tumors with a dismal prognosis, for which no standard therapy exists. A definitive molecular signature for RIGs has not yet been established. We sought to address this gap by performing a systematic review and meta-analysis of the molecular features of cranial RIGs. Methods A systematic review of the literature was performed according to Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. English language articles and case reports referring to radiation-induced high-grade gliomas located in the human brain that included molecular analyses were identified, evaluated and data extracted for collation. Results Of 1727 records identified, 31 were eligible, containing 102 unique RIGs with molecular data. The most frequent genetic alterations in RIGs included PDGFRA or TP53 mutations, PDGFRA or CDK4 amplifications, and CDKN2A deletion, along with 1q gain, 1p loss and 13q loss. Of note, mutations in ACVR1, EGFR, H3F3A, HIST1H3B, HIST1H3C, IDH2, SMARCB1 or the TERT promoter were not observed. A comparative analysis revealed that RIGs are molecularly distinct from most other astrocytomas and gliomas and instead align most closely with the pedGBM_RTK1 subgroup of pediatric glioblastoma. Conclusions This comprehensive analysis highlights the major molecular features of RIGs, demonstrates their molecular distinction from many other astrocytomas and gliomas, and reveals potential genetic drivers and therapeutic targets for this currently fatal disease.

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Defining the molecular features of radiation-induced glioma: A systematic review and meta-analysis

Whitehouse

Howlett

Federico

et al. 2021

Neuro-Oncology Advances

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“…One of the main contributions of DNA damage studies as also discussed in the Introduction, resides in the utilization of DDR knowledge for cancer sensitization in radiotherapy and chemotherapy [158], as recently reviewed in [159]. The accurate knowledge of the damage patterns and levels offers unique opportunities not only towards the advancement of therapy using for example protons or chemotherapy drugs such as bleomycin but also cancer generation (carcinogenesis).…”

Section: The Crucial Necessity To Study Dna Damage and Repairmentioning

confidence: 99%

In Situ Detection of Complex DNA Damage Using Microscopy: A Rough Road Ahead

Nikitaki

Pariset

Sudar

et al. 2020

Cancers

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Complexity of DNA damage is considered currently one if not the primary instigator of biological responses and determinant of short and long-term effects in organisms and their offspring. In this review, we focus on the detection of complex (clustered) DNA damage (CDD) induced for example by ionizing radiation (IR) and in some cases by high oxidative stress. We perform a short historical perspective in the field, emphasizing the microscopy-based techniques and methodologies for the detection of CDD at the cellular level. We extend this analysis on the pertaining methodology of surrogate protein markers of CDD (foci) colocalization and provide a unique synthesis of imaging parameters, software, and different types of microscopy used. Last but not least, we critically discuss the main advances and necessary future direction for the better detection of CDD, with important outcomes in biological and clinical setups.

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“…B. Vitamin B1, Vitamin B9) ist besonders kritisch. Merke Die unzureichende Versorgung der Krebspatienten mit antioxidativen Mikronährstoffen spiegeln auch die erhöhten Labormarker für oxidativen Stress wider.Auch über Zinkmangel-assoziierte Blutungen wird bei Krebspatienten mit schlechtem Ernährungsstatus berichtet[4,7,20].Nebenwirkungen der Chemo-und Strahlentherapie (z. B. Erbrechen, Diarrhö, Dysgeusie), Entzündungsprozesse sowie Inappetenz und Nahrungsmittelaversionen infolge einer Anorexie (z.…”

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Ausgewählte Mikronährstoffe in der onkologischen Intervention – ein Update

Gröber

Holzhauer

Kisters

2022

Deutsche Zeitschrift für Onkologie

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ZusammenfassungJe nach Tumorentität und Geschlecht supplementieren bis zu 90% der Krebspatienten antioxidative und immunrelevante Mikronährstoffe, häufig ohne das Wissen des behandelnden Arztes. Die Gründe für die Inanspruchnahme komplementärmedizinischer Therapien sind vielfältig, sie sind meist in einem patienteneignen, salutogenetisch orientierten Konzept zu Gesundung, Heilung und Bewältigung der Krebserkrankung sowie zur onkologischen Therapie zu finden. Aus Sicht der Patientinnen sind Aspekte mit hoher Priorität die Wahrung der Autonomie, die Verwirklichung einer Selbstbeteiligung und die Optimierung der Resilienz in einer kritischen, oft bedrohlichen Lebensphase, die es zu bewältigten gilt. Komplementäre Maßnahmen werden sowohl in der Akuttherapie als auch in der Nachsorge eingesetzt. Die Sicherheit und Kompatibilität der vielfältigen komplementären Maßnahmen mit der konventionellen Tumortherapie sind von größter Bedeutung. Onkologisch tätige Ärzte sollten daher über die aktuelle Bedeutung von Vitamin D, Selen, Omega-3-Fettsäuren und anderen (Mikro)nährstoffen sowie potenziellen Interaktionen mit der Krebstherapie informiert sein.

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Role of DNA damage and repair in radiation cancer therapy: a current update and a look to the future

Cited by 27 publications

References 72 publications

Defining the molecular features of radiation-induced glioma: A systematic review and meta-analysis

Defining the molecular features of radiation-induced glioma: A systematic review and meta-analysis

In Situ Detection of Complex DNA Damage Using Microscopy: A Rough Road Ahead

Ausgewählte Mikronährstoffe in der onkologischen Intervention – ein Update

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