Role of Drosophila in Human Disease Research 3.0

Cotterill, Sue; Yamaguchi, Masamitsu

doi:10.3390/ijms25010292

IJMS

2023

DOI: 10.3390/ijms25010292

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Role of Drosophila in Human Disease Research 3.0

Sue Cotterill,

Masamitsu Yamaguchi

Abstract: Drosophila melanogaster has become a commonly used animal model for biomedical research in a variety of areas [...]

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2024

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Cited by 3 publications

References 11 publications

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Harnessing Simple Animal Models to Decode Sleep Mysteries

Pandi-Perumal,

Saravanan,

Paul

et al. 2024

Mol Biotechnol

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Harnessing Simple Animal Models to Decode Sleep Mysteries

Pandi-Perumal,

Saravanan,

Paul

et al. 2024

Mol Biotechnol

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Drosophila melanogaster as an Alternative Model to Higher Organisms for In Vivo Lung Research

Ehrhardt,

Roeder,

Krauss-Etschmann

2024

IJMS

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COPD and asthma are lung diseases that cause considerable burden to more than 800 million people worldwide. As both lung diseases are so far incurable, it is mandatory to understand the mechanisms underlying disease development and progression for developing novel therapeutic approaches. Exposures to environmental cues such as cigarette smoke in earliest life are known to increase disease risks in the individual’s own future. To explore the pathomechanisms leading to later airway disease, mammalian models are instrumental. However, such in vivo experiments are time-consuming and burdensome for the animals, which applies in particular to transgenerational studies. Along this line, the fruit fly Drosophila melanogaster comes with several advantages for research in this field. The short lifespan facilitates transgenerational studies. A high number of evolutionary conserved signaling pathways, together with a large toolbox for tissue-specific gene modification, has the potential to identify novel target genes involved in disease development. A well-defined airway microbiome could help to untangle interactions between disease development and microbiome composition. In the following article, Drosophila melanogaster is therefore presented and discussed as an alternative in vivo model to investigate airway diseases that can complement and/or replace models in higher organisms.

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Climbing as a measurement of locomotion ability in the Drosophila model of fragile X syndrome

Makević,

Stojković,

Biorac

et al. 2024

Medicinska istraživanja

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Introduction: Fragile X syndrome (FXS) is the most common monogenetic cause of intellectual disability (ID) and autism spectrum disorder (ASD) in humans. The Drosophila melanogaster model of FXS (dFMR1 mutants) is an excellent model for research in the field of FXS. The aim of this study was a comprehensive investigation of climbing abilities, as a measurement of locomotion, in the dFMR1B55 line as a Drosophila model of FXS. Methods: In this study, control w1118 and dFMR1B55 lines of fruit flies were used. The climbing performance of flies was examined using a climbing performance assay for groups of flies as well as for individual flies. Parameters that represent climbing ability, speed and endurance were determined. Females and males were analyzed separately. Results: This study revealed the following: (i) worse climbing performance of dFMR1B55 males in comparison to w1118 males; (ii) worse climbing success of dFMR1B55 females in comparison to w1118 females; (iii) better climbing performance of top performer males in comparison to top performer females in the group climbing test in both dFMR1B55 and w1118 groups; (iv) better, but not statistically significant, climbing performance (based on the time needed for 50% of flies to complete the task), and a higher success rate in dFMR1B55 females in comparison to dFMR1B55 males. Conclusion: According to the results of the current study, climbing impairment was proved only in dFMR1B55 males, while dFMR1B55 females had climbing abilities similar to control w1118 females.

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Role of Drosophila in Human Disease Research 3.0

Abstract: Drosophila melanogaster has become a commonly used animal model for biomedical research in a variety of areas [...]

Cited by 3 publications

References 11 publications

Harnessing Simple Animal Models to Decode Sleep Mysteries

Harnessing Simple Animal Models to Decode Sleep Mysteries

Drosophila melanogaster as an Alternative Model to Higher Organisms for In Vivo Lung Research

Climbing as a measurement of locomotion ability in the Drosophila model of fragile X syndrome

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