Role of Dynamic Contrast-Enhanced and Diffusionweighted Mri in Evaluation of Response of Hepatocellular Carcinoma After Chemoembolization.

Abstract

Background: Hepatocellular carcinoma (HCC) accounted as the sixth most prevalent cancer worldwide and the third most common cancer leading to death. However unfortunately only a minority HCC patients are surgical candidates at the time of diagnosis, Transcatheter arterial chemoembolization (TACE) is one of the most commonly used intra-arterial therapies to treat unresectable HCC, Assessing early response to therapy using objective criteria is paramount for clinical care.

Comparison between triphasic CT and dynamic MRI in assessment of tumor response in HCC patients after Transarterial chemoembolization

“…Our results about ROC curve analysis were consistent with Guirguis et al [15] found that the sensitivity of dynamic MRI was 95.8%, indicating its ability to accurately detect positive cases. The specificity was 92.9%, indicating its ability to accurately identify negative cases.…”

“…Contrast washout was detected in 40(66.7%) cases in portal phase and 63.3% in delayed phase. Our results were supported by Guirguis et al [15] reported that The study of Pre-contrast T 1 revealed that among the 24 cases treated with LR, 25.0% showed heterogeneous T 1 signal intensity and 75% showed low T 1 signal intensity. Additionally, 25.0% showed heterogeneous T 2 signal intensity and 75% showed low T 2 signal intensity.…”