Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Saxena, S. K.; Thimmaraju, KV; Srivastava, Prem C.; Mallick, Ayaz Khurram; Das, Biswajit; Sinha, Nishita; Dalmia, Kanchan

doi:10.15380/2277-5706.jcsr.14.059

Cited by 6 publications

(5 citation statements)

References 24 publications

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“…A study conducted by Gandhi M et al, 14 There was a positive correlation between serum uric acid with systolic (r = +0.454, P <0.001) and diastolic blood pressure (r = +0.471, p < 0.001). Similar findings were seen in studies done by Sonagra et al, 19 P Josephine et al 20 and Saxena et al 21 Mustaphi et al 22 observed that when the levels of diastolic BP is increased, the levels of serum uric acid was also increased, concluding a positive correlation between diastolic BP and serum uric acid. Correlation Coefficient r value with systolic BP in similar studies by Sonagra et al, 19 P Josephine et al 20 and Saxena et al 21 were 0.408, 0.287 and 0.214 respectively whereas r value with diastolic BP in same studies were 0.420, 0.235 and 0.367 respectively.…”

Section: Discussionsupporting

confidence: 84%

Correlation between various biochemical biomarkers and blood pressure in pregnant women

Kaur

Shukla

Kumar

et al. 2022

Nepal J Obstet Gynaecol

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Aims: To find out the correlation of C-reactive protein, serum uric acid and serum LDH with hypertensive antenatal patients. Methods: The present study was conducted among preeclamptic and eclamptic antenatal patients. Serum was used for estimation of serum levels of CRP, LDH and Uric acid. The data obtained was compiled and analyzed statistically and was expressed in terms of mean±SD and percentage. Student t-test, Chi-square test, Pearson’s Correlation Coefficient were used and p value less than 0.05 was considered significant. Results: A positive correlation was found between serum CRP level and systolic blood pressure (r = +0.525, P=0.001) & serum CRP level diastolic systolic blood pressure (r= + 0.493, P=0.001). There was a positive correlation between serum uric acid with systolic (r= +0.454, P <0.001) and diastolic blood pressure (r = +0.471, p < 0.001). There was positive correlation between Serum LDH with systolic (r =+0.385, p value of r <0.001) and diastolic BP (r = +0.420, p value of r < 0.001). Conclusion: Hyperuricemia, increased serum CRP and LDH level can be used as biomarkers for identifying women at risk of preeclampsia and its complications along with adverse effects. We conclude that CRP, serum LDH and Serum Uric acid are reliable and inexpensive markers to predict severity of hypertensive disorders of pregnancy.

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Section: Discussionsupporting

confidence: 84%

Correlation between various biochemical biomarkers and blood pressure in pregnant women

Kaur

Shukla

Kumar

et al. 2022

Nepal J Obstet Gynaecol

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“…Many studies determined contradictory results of elevated ROS and TBARS but reduced antioxidants in PE (Cohen et al, 2015;Mutlu-Türko et al, 1998). Increased TBARS levels showed the increase lipid peroxidation in cells and may suggest decreased enzymatic free radical scavenging capacity in preeclamptic patients (Biri et al, 2007;Gupta et al, 2009;Saxena et al, 2015).…”

Section: Discussionmentioning

confidence: 99%

Placental endothelial nitric oxide synthase expression and role of oxidative stress in susceptibility to preeclampsia in Pakistani women

Shaheen

Jahan

Ain

et al. 2019

Molec Gen & Gen Med

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Background: Preeclampsia (PE): a hypertensive disorder of pregnancy characterized by de novo development of concurrent hypertension and proteinuria. The prevailing theory determined that PE starts from the placenta and ends in the maternal endothelium. Role of endothelial dysfunction in the onset of PE has been reported in different populations. Therefore, present study was designed to investigate the localization and expression of endothelial nitric oxide synthase (eNOS) and role of oxidative stress markers in preeclamptic Pakistani women. Methods: A total of 400 blood samples (PE = 200, controls = 200) and 100 placental tissues (PE = 50, controls = 50) were recruited from pregnant women. Reactive oxygen species (ROS), thiobarbituric acid reactive substances (TBARS), superoxide dismutase (SOD), catalase (CAT), and guaiacol peroxidase (POD) levels were analyzed through spectrophotometer. Immunohistochemistry and quantitative real-time polymerase chain reaction (qRT-PCR) were carried out to estimate the localization and expression of eNOS in the placentas of PE patients and healthy pregnant women. Results: Significantly increased levels of POD (0.01), TBARS (0.04), and ROS (p ≤ .001) were determined in preeclamptic women while, nonsignificant changein SOD and CAT was observed in both groups. Reduced eNOS immunoreactivity (p ≤ .001) and mRNA abundance (p ≤ .001) was observed in preeclamptic group as compared to control group. Conclusion: Considering the results of current study, it is concluded that decreased eNOS expression and oxidative stress could play a role in the pathology of PE seen both in placenta and ultimately in maternal endothelium. However, large studies are necessary to validate these findings to prevent maternal and neonatal morbidity and mortality in Pakistani population. K E Y W O R D Sendothelial nitric oxide synthase, oxidative stress, placenta, preeclampsia

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“…[6][7][8][9][10][11] Jin WY et al, Saha D et al, Saxena S et al, Vidyabati RK, Islam NAF and Aziz R they all agree on the fact that dyslipidemia was significantly associated with pre eclampdia and eclampsia. [6][7][8][9][10][11] As hypertensive disorder developed, there was development of fetal complications. The women with severe dyslipidemia developed fetal complication of severe IUGR and IUD in their late second and early third trimester with very poor outcome.…”

Section: Discussionmentioning

confidence: 95%

Feto-maternal impact of altered lipid profile in pregnancy

Singh¹,

Kujur²,

Jain³

2017

Int J Reprod Contracept Obstet Gynecol

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INTRODUCTIONHypertensive disorders complicate approximately 10% of all pregnancies worldwide, with onset of symptoms in the late second or third trimester, most commonly after the 32nd week.1 The national incidence is reported to be 8-10%.2 Preeclampsia is one of the major cause of maternal mortality in developed and developing countries. It is also a leading cause of perinatal morbidity and mortality and it is very strongly related to fetal growth retardation. To avoid complications, it is very important to diagnose it early, but the available tools are unable to clinch the diagnosis of preeclampsia effective in majority. Pregnancy-induced hypertension(PIH) is one of the major risk factors in present day health care practice because it not only causes maternal mortality but also impaires fetal development during pregnancy. Pre-eclampsia is a multi-system disorder of pregnancy, which is characterised by new onset hypertension and proteinuria that develop after 20 weeks of gestation in previously normotensive women. Pregnancy-induced hypertension(PIH) is one of the major risk factors in present day health care practice because it not only causes Results:Out of 200 antenatal women recruited in our study, 129 had normal lipid profile throughout pregnancy and 71 women developed dyslipidemia.89 % of those women having normal lipid profile did not develop any maternal or perinatal complication, showing a high negative predictive value (88.72%) and high specificity of 91.47%. We observed that the onset of dyslipidemia occurred in 2nd trimester and it was progressive. About 83.58 % of them developed toxemia of pregnancy (GHTN, preeclampsia, eclampsia), positive predictive value of 83.58%. The levels of TC (total cholesterol), TG(triglyceride), VLDL (very low-density lipoprotein) and LDL (low density lipoprotein) were significantly (p<0.0001) higher in hypertensive women than normotensive women. Dyslipidemic women have developed significant (p= 0.00001) level of perinatal complications like preterm (18.05%), IUGR (15.28%) and IUD (13.89%). Sensitivity-78.9, Specificity-88.72, Positive likelihood ratio-9.25, Negative likelihood ratio-0.23. Conclusions: Early pregnancy dyslipidemia was significantly associated with an increased risk of preeclampsia and eclampsia. Thus, evaluating dyslipidemia in 1 st and 2 nd trimester may help in early prediction and management of maternal as well as fetal complication.

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Role of dyslipidaemia and lipid peroxidation in pregnancy induced hypertension

Cited by 6 publications

References 24 publications

Correlation between various biochemical biomarkers and blood pressure in pregnant women

Correlation between various biochemical biomarkers and blood pressure in pregnant women

Placental endothelial nitric oxide synthase expression and role of oxidative stress in susceptibility to preeclampsia in Pakistani women

Feto-maternal impact of altered lipid profile in pregnancy

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