Role of Early Diagnosis and Multimodal Treatment in Rhinocerebral Mucormycosis: Experience of 4 Cases

Prasad, Kavitha; Lalitha, R.M.; Reddy, Eashwer K.; Ranganath, K.; Srinivas, D.; Singh, Jasmeet

doi:10.1016/j.joms.2011.02.017

Cited by 20 publications

(18 citation statements)

References 22 publications

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“…One of the 2 patients who received only antifungal therapy died; the survivor received liposomal amphotericin B which had been previously reported to be able to achieve cure even in the absence of associated surgery ( 20 ). The success rates of a multimodal treatment approach in our study are similar to those achieved across many centers around the world ( 4 , 5 , 19 ). The long term morbidity related to consequences of the fungal disease was also minimal and confined to the sequelae of tissue loss from radical surgeries.…”

Section: Discussionsupporting

confidence: 86%

“…The cornerstone of management is a combination of antifungal drugs and early surgical debridement of involved tissues that may prevent extension of infection to the surrounding areas ( 4 , 19 ). Treatment with antifungals alone is usually ineffective due to poor concentrations in affected tissues resulting from vascular invasion, thrombosis, occlusion and infarction ( 4 ).…”

Section: Discussionmentioning

confidence: 99%

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Clinical spectrum and outcome of invasive filamentous fungal infections in children with Type 1 diabetes: North Indian experience

Dayal

Jain

Kumar

et al. 2015

Clin Pediatr Endocrinol

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There is scarcity of data on spectrum and outcome of invasive filamentous fungal infections (IFIs) in children with Type 1 diabetes (T1D) from developing countries. A retrospective review of medical records of children with T1D hospitalized with IFI over the past decade at the Pediatric Endocrinology and Diabetes Unit of a large tertiary care hospital of North India was performed with an aim to study their clinical spectrum, hospital course and final outcome. Of the 10 patients studied, nasal/paranasal involvement was seen in 6 and pulmonary involvement in 5 patients. One patient developed disseminated disease. Majority of the identified mycoses belonged to Class Zygomycetes Order Mucorales. Early surgery along with antifungal therapy helped limit the extension of infection and achieve a good outcome in majority of patients. Two patients died; one with a late diagnosis of pulmonary mucormycosis and the other with disseminated disease. The longterm morbidity in the survivors was minimal. In conclusion, rapid diagnosis followed by a multimodal approach involving aggressive surgical debridement, appropriate antifungal therapy and control of hyperglycemic state is the key to good outcome in this otherwise lethal infection.

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Section: Discussionsupporting

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Clinical spectrum and outcome of invasive filamentous fungal infections in children with Type 1 diabetes: North Indian experience

Dayal

Jain

Kumar

et al. 2015

Clin Pediatr Endocrinol

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“…The dosage varies from 0.5 to 1.5 mg/kg body weight once daily for not less than 4 weeks. There should be close monitoring of serum electrolytes, as polyenes are known to cause potassium imbalance [12]. Data from comparison of lipid complex amphotericin B and deoxycholate amphotericin B showed improved survival rates and less side effects with lipid complex amphotericin B [13].…”

Section: Discussionmentioning

confidence: 99%

Rhinomaxillary osteomyelitis due to mucormycosis in an immunocompromised geriatric patient

Singh¹,

Pandey²,

Agrawal³

2015

Egyptian Journal of Oral & Maxillofacial Surgery

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Mucormycosis is a type of an opportunistic fungal infection, which most commonly involves structures in the maxillofacial region, such as the paranasal air sinuses, maxilla, and orbit and in advanced stages it may affect the brain. The most common route of its entry is through inhalation. A common predisposing condition is diabetes mellitus, leading to an immunocompromised state. We present a case of a 63-year-old female patient with widespread maxillary osteomyelitis following teeth extraction, which was later diagnosed as mucormycosis.

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“…The gold standard imaging method is contrast-enhanced computed tomography which shows opacification of sinuses, edematous mucosa and bone destruction, soft tissue swelling and swelling of extraocular muscles [5]. T2-weighted MR images demonstrate intracerebral infection and enhanced images may detect early vascular invasion [5].…”

Section: Discussionmentioning

confidence: 99%

“…T2-weighted MR images demonstrate intracerebral infection and enhanced images may detect early vascular invasion [5]. The need for nephrotoxic drugs during treatment argues in favor of the use of MRI, since repeated imaging is usually needed for follow-up.…”

Section: Discussionmentioning

confidence: 99%

Successful therapy of progressive rhino-orbital mucormycosis caused by Rhizopus arrhizus with combined and sequential antifungal therapy, surgery and hyperbaric therapy

Imbernón

Agud

Cuétara

et al. 2014

Medical Mycology Case Reports

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Role of Early Diagnosis and Multimodal Treatment in Rhinocerebral Mucormycosis: Experience of 4 Cases

Cited by 20 publications

References 22 publications

Clinical spectrum and outcome of invasive filamentous fungal infections in children with Type 1 diabetes: North Indian experience

Clinical spectrum and outcome of invasive filamentous fungal infections in children with Type 1 diabetes: North Indian experience

Rhinomaxillary osteomyelitis due to mucormycosis in an immunocompromised geriatric patient

Successful therapy of progressive rhino-orbital mucormycosis caused by Rhizopus arrhizus with combined and sequential antifungal therapy, surgery and hyperbaric therapy

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