Role of edge activators and surface charge in developing ultradeformable vesicles with enhanced skin delivery

El-Zaafarany, Ghada M.; Awad, Gehanne A.S.; Holayel, Samar Mansour; Mortada, Nahed D.

doi:10.1016/j.ijpharm.2010.06.034

Cited by 439 publications

(324 citation statements)

References 56 publications

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“…These results agreed with that reported by El-Zaafrany et al [22]. The authors found that increasing surfactant content from 2% to 5% (W/W) increased the EE% non-significantly but further increase in its content showed a decrease in EE%.…”

Section: Discussionsupporting

confidence: 92%

“…The use of thin film hydration method in the present work may be advantageous in improving EE compared with vortexing method [22]. All the tested BD-T formulations showed a relatively high EE% ranged from 69.1%±0.80 to 90.1%±0.76 (table 2).…”

Section: Discussionmentioning

confidence: 86%

“…All the tested BD-T formulations showed a relatively high EE% ranged from 69.1%±0.80 to 90.1%±0.76 (table 2). This increase in EE% may be attributed to the formation of a thin film with a large surface area which facilitates the complete hydration of vesicles [22].…”

Section: Discussionmentioning

confidence: 99%

“…The stability of BD loaded transfersomes was evaluated after storage for 6 mo at 4 °C and 25 °C by studying the change in the organoleptic characters, drug content (chemical stability) and in vitro drug release (physical stability) [19,[22][23][24][25][26][27][28][29].…”

Section: Stability Studymentioning

confidence: 99%

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Betamethasone Dipropionate Gel for Treatment of Localized Plaque Psoriasis

Gizaway

Fadel

Mourad

et al. 2017

Int J Pharm Pharm Sci

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Objective: The main aim of this study was to design and characterise betamethasone di-propionate loaded transfersomes (BD-T); as a topical formulation for the treatment of localized plaque psoriasis. 3 ) was applied to study the effects of three independent variables: drug content, type of surfactants and surfactant contents on particle size (PS), entrapment efficiency (EE %), zeta potential (ZP), polydispersity index (PI) and drug release profiles. The optimized BD-T was formulated as a hydrogel using 5% sodium carboxymethyl cellulose. The gel was characterized for viscosity, drug content, in vitro drug release and stability. A comparative clinical study was performed on 20 patients with psoriasis to investigate the effect of BD-T gel and the marketed betamethasone dipropionate (BD) cream. Methods Results:The optimized BD-T formulation containing 50 mg betamethasone dipropionate (BD) and 5 mg tween 80 showed spherical unilamellar vesicles with an average particle size of 242.80, % EE of 90.19%, ZP of-15.00 mV, PI of 0.407 and K0 Keywords: Transfersomes, Betamethasone dipropionate (BD), Localized psoriasis of 4.290 mg/hr. The formulation showed good stability at 4 °C and 25 °C for 6 mo. The results revealed significant clinical improvement and a significant increase in safety and tolerability with BD-T gel compared with BD cream. Conclusion:As a conclusion, BD-T was found to be more effective, safe and tolerable for the treatment of psoriasis compared with the marketed product.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 86%

Section: Discussionmentioning

confidence: 99%

Section: Stability Studymentioning

confidence: 99%

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Betamethasone Dipropionate Gel for Treatment of Localized Plaque Psoriasis

Gizaway

Fadel

Mourad

et al. 2017

Int J Pharm Pharm Sci

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“…In the process, transfersomes go through a series of stress-dependent adjustments of the local carrier symphony to minimize the struggle of motion through the otherwise confining channels. This process allows transfersomes to convey the drugs associated into and diagonally across the skin easily and very reproducibly. This happens at a rate largely higher than that achieved by more predictable formulations and offers an excellent means for controlling drug distribution in the skin [19,20]. Transfersomes have been used as carriers for different therapeutic agents, including proteins, insulin [21,22], DNA [23], gap junction protein [24], peptides [25], albumin [15], nutraceuticals [26], corticosteroids [27], antigens [28], analgesics [29], sex hormones [30], and anesthetics [31], and have been proven to augment significantly the amount of drug permeated through the skin [10]. The topical application of transfersome-entrapped anticancer drug is described by a few research groups.…”

Section: Merits/demeritsmentioning

confidence: 99%

Transfersomes as versatile and flexible nano-vesicular carriers in skin cancer therapy: the state of the art

Rai¹,

Pandey²,

Rai³

2017

Nano Reviews & Experiments

208

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Introduction: The skin acts as a barrier and prevents transcutaneous delivery of therapeutic agents. Transfersomes are novel vesicular systems that are several times more elastic than other vesicular systems. These are composed of edge activator, phospholipids, ethanol, and sodium cholate and are applied in a non-occlusive manner. Areas covered: This article covers information such as merits/demerits of transfersomes, regulatory aspects of materials used in preparation, different methods of preparation, mechanism of action, review of clinical investigations performed, marketed preparations available, research reports, and patent reports related to transfersomes. Expert opinion: Research over the past few years has provided a better understanding of transfersomal permeation of therapeutic agents across stratum corneum barrier. Transfersomes provides an essential feature of their application to variety of compositions in order to optimize the permeability of a range of therapeutic molecules. This is evidenced by the fact that there are several Transfersome products being processed in advanced clinical trials. It is noteworthy that a number of Transfersome products for dermal and transdermal delivery will gain a global market success in near future.

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