Role of Efflux Pumps in Reduced Susceptibility to Tigecycline among Clinical Isolates of Acinetobacter baumannii

Mahapatra, Ashoka; Pati, Amresh; Gupta, Kavita

doi:10.4103/ijabmr.ijabmr_219_22

Cited by 1 publication

(1 citation statement)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…They are involved in extruding hazardous substances, including antibiotics, from within the bacterial cells [19]. The overexpression of these efflux pumps, particularly AdeABC, has been found to enhance the survival of A. baumannii when exposed to residual concentrations of biocides [20]. Additionally, efflux pump genes, such as adeABC, have been associated with tigecycline resistance in A. baumannii [21].…”

Section: The Mechanisms Of a Baumannii To Promote Self-survivalmentioning

confidence: 99%

The Battle Against Antibiotic Resistance: Novel Therapeutic Options for Acinetobacter baumannii

Emami,

Pirbonyeh,

Javanmardi

2023

Acinetobacter Baumannii - The Rise of a Resistant Pathogen

View full text Add to dashboard Cite

Undoubtedly, Acinetobacter baumannii stands out as one of the most effective bacteria responsible for nosocomial infections within the healthcare system. Due to its multidrug-resistant nature and the frequency of outbreaks that it causes the treatment of infections caused by this bacterium is challenging, antimicrobial combination therapy has been utilized to treat multidrug resistance Gram-negatives when monotherapy is ineffective. In contrast to antibiotics or short peptides, which possess only the capacity to bind and regulate a specific target, antibodies exhibit supplementary properties attributed to their Fc region, including opsonophagocytic activity, the agglutination process, and activation of the complement system. The criticality of antibodies is exemplified in triggering immunity against A. baumannii, stimulating protective mechanisms, preventing bacterial attachment to epithelial cells, opsonization, and complement-dependent bacterial destruction. Given antibodies’ significant role in humoral immunity, monoclonal antibodies (mAbs) may be generated to specifically bind to certain targets, thereby providing supplemental defense as a form of immunotherapy or passive immunization. Many encouraging tactics, ranging from phage therapy to immunotherapy, are being scrutinized for their efficacy in treating infectious diseases, thus shaping the future treatment landscape.

show abstract

Section: The Mechanisms Of a Baumannii To Promote Self-survivalmentioning

confidence: 99%