Role of Electro-Diagnostic Tests In Early Detection of Diabetic Neuropathy

Ali, Zahed; Hakim, Maliha; Islam, Mohammed Sirajul; Bhowmik, Nirmalendu Bikash; Nahar, Shamsun; Ullah, Akm Anwar; Haque, Ashraful

doi:10.3329/bjn.v24i1.3038

Cited by 3 publications

(4 citation statements)

References 22 publications

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“…It was found that among the Sensory nerve conduction parameters, Sensory nerve action potential amplitude (SNAP) was affected more than conduction velocity. [14] This finding is parallel to the current study findings. Amina Zaidi et al, in their study, explored the correlation between Duration of diabetes and SNCS parameters of Median, Ulnar, Sural and Superficial peroneal nerves; and a significant negative correlation (p<0.05) was found.…”

Section: Pathogenesis Of Diabetic Neuropathysupporting

confidence: 91%

“…Very few studies have been undertaken to study the correlation and effect of Duration of diabetes and Nerve conduction study parameters. [11][12][13][14] Hence, the aim of the present study is to study the effect of duration of diabetes on Sural nerve conduction parameters in type-II Diabetes Mellitus. Nerve conduction velocity (NCV) and Sensory Nerve Action Potential (SNAP) amplitude of Bilateral Sural nerves were the parameters to be studied.…”

Section: Introductionmentioning

confidence: 99%

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Effect of Duration of Diabetes on Sural Nerve Conduction Parameters in Subjects with Type-II Diabetes Mellitus - A Cross sectional Comparative Study

Pattni

Prajapati²

2022

Int J Health Sci Res

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Background: Diabetes mellitus has become a rapidly rising global health-care problem in the recent decades. Amongst the wide spectrum of concurrent complications, Diabetic peripheral neuropathy (DPN) is quite common and distressing. The sensory symptoms may vary from numbness, hypo-aesthesia, allodynia to severe paresthesia. Long term consequences of these sensory disturbances are foot ulceration, imbalance, increased risk of fall and even amputations too. Since these symptoms interfere with the quality of life of diabetic individuals and also lead to increased socio-economic burden, immediate action to combat these is pre-requisite for health care development of any nation. Further, if timely diagnosed, these complications can largely be prevented. Nerve conduction study holds the gold standard tool to detect Diabetic neuropathy at its subclinical stage itself. Sural nerve is the commonest and most prevalent nerve involved, so it was considered for analysis. Duration of diabetes is an important factor which affects neurophysiology. Thus, the aim of the present study is to study the effect of duration of diabetes on Sural nerve conduction parameters in subjects with type-II Diabetes Mellitus having varying duration of diabetes. Method: Seventy-three Subjects with type-II Diabetes mellitus were divided into three groups according to the duration of disease. Group A:<5 years, B: 5-10 years, C: >10 years of diabetes. Bilateral Sural nerves were analysed using RMS EMG SALUS machine. Result: Significant reduction of Sensory nerve action potential (p<0.05) was found as the duration of diabetes increased from Group A to C. Conclusion: Long term Diabetes leads to Axonal degeneration in Sural nerves. Key words: Diabetic peripheral neuropathy, Nerve conduction study, Sural nerves, Diabetes mellitus, Duration of Diabetes, Axonal degeneration.

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Section: Pathogenesis Of Diabetic Neuropathysupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Effect of Duration of Diabetes on Sural Nerve Conduction Parameters in Subjects with Type-II Diabetes Mellitus - A Cross sectional Comparative Study

Pattni

Prajapati²

2022

Int J Health Sci Res

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“…The difference in reduction of SNCV of lower limbs is greater than that in upper limbs, showing that long nerves are comparatively more affected. [8] Conduction abnormalities develop diffusely along the entire length of nerve but more in distal than the proximal segment The NCV is gradually diminished by Diabetic Neuropathy, with estimate of a loss of approximately 0.5m/s/year and a simple rule is that 1% fall in HbA1c improves the conduction velocity of about 1.3m/s (Arezzo,1997). Correction of Hyperglycemia in patients results in improvement of symptoms as well as nerve conduction abnormalities (Judzewitsch et al,1983).Elizabeth et al 1998 volume 245; number 2/Jan 1998 studied about the assessment of neuropathy in diabetic patients by study of the conduction velocity within motor and sensory fibres and came to a conclusion that longer the duration of diabetes, changes in the motor and sensory responses of the individual is certain.…”

Section: Discussionmentioning

confidence: 99%

“…These studies were also consistent with the previous study done by OLNEY; RICHARD K 1998 Also, the present study was comparable to the study done by Verma et.al who showed that in comparision to normal healthy volunteers, amplitude and conduction velocity range is significantly decreased in diabetic patients [10] and most affected nerve in upper limb being Median nerve and lower limb is sural nerve which is also comparable with study done by Zahed Ali et.al. [8] A study done by Xuan Kong et al demonstrated that NCS using a computer based electrodiagnostic equipment was a suitable tool for the diagnosis of Diabetic Polyneuropathy. [11] V. Conclusion…”

Section: Discussionmentioning

confidence: 99%

A Comparative Peripheral Nerve Conduction Study in Type-2 Diabetics with Symptoms of Polyneuropathy with Age and Sex Matched Normal Subjects

Mankar¹,

Dr.Bhagya.²,

Bondade³

2016

IOSR

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Methods: The study group consists of 9 cases diagnosed with Diabetic neuropathy referred to our neurophysiology lab and control group consists of 9 age and sex matched normal subjects who are nondiabetic, healthy volunteers. Statistical analysis was done using unpaired t-test and 8 out of 9 cases considered for statistical analysis. Motor and Sensory nerve conduction studies conducted in both Upper (Median and Ulnar nerves) and Lower limbs (Tibial and Peroneal nerves) using bipolar surface electrodes with RMS EMG

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Asymptomatic Median Neuropathy in Patients with Diabetic Polyneuropathy

Alemdar¹

2021

Neurological Sciences and Neurophysiology

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Aim: This study aims to investigate whether asymptomatic median neuropathy (AMN) in patients with diabetic peripheral polyneuropathy (DPNP) is a result of polyneuropathic involvement of median nerve (MN) or its true entrapment. Subjects and Methods: We determined the grades of the Michigan severity scale and the rates of peripheral nerve conduction abnormalities in study subgroups, including patients with carpal tunnel syndrome (CTS), AMN, and normal MN conductions to highlight if the severity of polyneuropathic involvement was different between them. In addition, the results of conventional and comparative nerve conduction studies (NCSs) were compared between these study subgroups. Results: Distributions of Michigan grades and rates of abnormalities in peroneal and sural NCSs were similar between the subgroups (P > 0.05 for all analyses). Abnormality rates of ulnar NCSs were higher in the AMN group than in the other groups, whereas those of comparative transcarpal NCSs were higher in the CTS group. The mean distal sensory latency (DSL) and motor latency (DML) of MN were longer, sensory conduction velocity (SCV) was slower in the CTS group than AMN group, whereas MN motor conduction velocity (MCV) was slower, UN DSL was longer, SCV was slower, SNAP amplitude was smaller, DML was longer, and MCV were slower in the AMN group (P < 0.05 for all analyses). Discussion: Our findings reveal that grade of polyneuropathic involvement is more prominent in AMN, whereas transcarpal MN conduction delay is greater in CTS. The results of the study suggest that the prominence of polyneuropathic impairment in addition to a lesser degree of MN sheet compression obscures the clinical signs in patients with diabetes with AMN.

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Role of Electro-Diagnostic Tests In Early Detection of Diabetic Neuropathy

Abstract: Abstact

Cited by 3 publications

References 22 publications

Effect of Duration of Diabetes on Sural Nerve Conduction Parameters in Subjects with Type-II Diabetes Mellitus - A Cross sectional Comparative Study

Effect of Duration of Diabetes on Sural Nerve Conduction Parameters in Subjects with Type-II Diabetes Mellitus - A Cross sectional Comparative Study

A Comparative Peripheral Nerve Conduction Study in Type-2 Diabetics with Symptoms of Polyneuropathy with Age and Sex Matched Normal Subjects

Asymptomatic Median Neuropathy in Patients with Diabetic Polyneuropathy

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