Role of elevated liver transaminase levels in the diagnosis of liver injury after blunt abdominal trauma

Tian, Zhiqiang; Liu, Hong; Su, Xiao-Fang; Zheng, Fang; Dong, Zhifeng; Yu, Chunrong; Luo, Kun

doi:10.3892/etm.2012.575

Cited by 43 publications

(38 citation statements)

References 17 publications

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“…A study conducted by Tian et al found a trend that the more severe the liver injury of the patients, the higher the liver enzyme levels, but their study further demonstrated that patients with elevated ALT>100 U/l, AST>113 U/l did not necessarily have major liver injury. 18 This study is in agreement with the latter study, with mean ALT levels increasing with increasing grade of injury. But further studies with a larger sample size and inclusion of patients with grade 5 and 6 liver injuries are needed to achieve an authentic conclusion for the same.…”

Section: -13supporting

confidence: 82%

Evaluating the role of liver enzymes as predictors of severity of liver injury in patients with blunt abdominal trauma

et al. 2017

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Background: Liver is the 2nd most common organ affected in patients with blunt abdominal trauma (BAT). Computed tomography (CT) is the gold standard in the initial evaluation of the hemodynamically stable patient with suspected liver trauma. However, a challenge exists in centers devoid of CT scan, where an elevation in hepatic transaminases may provide guidance for the emergency physician in seeking further imaging and/or surgical consultation.Methods: In patients with suspected BAT blood samples were taken for estimation of liver enzymes (AST and ALT). All patients underwent contrast enhanced CT of the abdomen. Hemodynamically unstable patients were taken up for laparotomy and the findings were recorded. Based on imaging / surgery patients were subdivided into 2 groups (with and without liver injury). Liver injuries were graded according to organ injury scale by American Association of Surgery for Trauma.Results: ALT>100 units had 100% sensitivity and specificity improved to 83.78%. The mean level of ALT in patients without liver injury was around 64. This increased to 142 in grade 1 and upto 780 units in grade 4 injury. The same rising trend was seen when AST was evaluated against grade of Liver injury. This was statistically significant (p<0.01).Conclusions: ALT is the better of the transaminases in predicting liver injury. The rise in transaminases is directly proportional to grade of liver injury.

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Section: -13supporting

confidence: 82%

Evaluating the role of liver enzymes as predictors of severity of liver injury in patients with blunt abdominal trauma

et al. 2017

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“…The serum activities of ALT and AST have been reported to be increased as a result of liver injury in patients developing severe hepatotoxicity (Beckett, 1989;Tian et al, 2012). Chemical and organic toxicants like crude oil are known to cause liver damage and precipitate elaboration of ALT and AST above the basal level in the serum (Chang et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Effects of Vitamin E Supplementation in Male Rats with Crude Oil-Induced Reproductive Toxicity

et al. 2017

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Crude oil intoxication is a major threat among people and animals living around the crude oil producing regions of the world, hence the search for ameliorating agents. Forty-four male Wistar rats assigned to three groups were used to investigate the effects of vitamin E supplementation on crude oil-induced reprotoxicity (reproductive toxicity) in male rats. Group A represented the unexposed control, whereas groups B and C were exposed orally to 0.15 and 0.3 ml of crude oil respectively every other day, for 56 days. Both the low dose and high dose oral administration of crude oil caused a significant reduction in the serum testosterone level (STL) and cauda epididymal sperm reserve (CESR) of the exposed rats when compared to the control. Crude oil withdrawal and vitamin E supplementation significantly improved the cauda epididymal sperm reserve (CESR) in all the subgroups. The serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities of the control and low dose group were significantly lower than those of the high dose group. The high dose crude oil administration significantly decreased the mean serum total protein (STP) and sodium ions (Na + ) concentration. The mean serum total cholesterol (STC) value of the low dose group was significantly higher than those of the control and high dose group. However, crude oil withdrawal and vitamin E supplementation did not significantly alter the mean serum total protein (STP) and mean serum total cholesterol (STC) values in all the subgroups. Vitamin E supplementation following low dose crude oil withdrawal enhanced the mean serum Chloride ions (Cl -) concentration. The present findings revealed that Nigerian Qua Iboe Brent crude oil induced serious reprotoxic effects in male rats which vitamin E administration within 28 days did not completely reverse.

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“…16,17 Some studies have shown an association between elevated liver enzymes and blunt liver trauma, but no consensus has been reached regarding its value in guiding management. 18,19 Imaging With improved access, availability, and sensitivity of imaging, as well as improved critical care management, there has been a shift in the management of hepatic trauma from surgical management to more NOM strategies. 20 Previous reports have shown that up to 86% of patients with hepatic trauma have stopped bleeding by the time of surgery, and in up to 67% of these patients, surgical intervention had no therapeutic value.…”

Section: Laboratory Studiesmentioning

confidence: 99%

Management of Hepatic Trauma: An Update

Lang

Dahan

et al. 2018

Dig Dis Interv

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Being the largest solid abdominal organ, the liver is the second most commonly injured organ after abdominal trauma. In this review, we discuss the American Association for the Surgery of Trauma's (AAST) liver injury grading system and World Society of Emergency Surgery's triage grading system. Furthermore, we discuss the role of imaging in hepatic trauma, as well as the indications, techniques, and roles of nonoperative and operative management.

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Role of elevated liver transaminase levels in the diagnosis of liver injury after blunt abdominal trauma

Cited by 43 publications

References 17 publications

Evaluating the role of liver enzymes as predictors of severity of liver injury in patients with blunt abdominal trauma

Evaluating the role of liver enzymes as predictors of severity of liver injury in patients with blunt abdominal trauma

Effects of Vitamin E Supplementation in Male Rats with Crude Oil-Induced Reproductive Toxicity

Management of Hepatic Trauma: An Update

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