Role of Embryonic and Differentiated Cells in Cardiac Development

Yamak, Abir; Nemer, Mona

doi:10.1007/978-3-319-10972-5_2

Cited by 2 publications

(1 citation statement)

References 210 publications

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“…The first and second heart fields (FHF and SHF, respectively) as well as the proepicardial organ and the cardiac neural crest are the major contributors to the forming heart (Martinsen and Lohr, 2015). The FHF gives rise primarily to the left ventricle and most of the atria; the SHF contributes to the right ventricle, outflow tract, and parts of the atria (Srivastava, 2006;Yamak and Nemer, 2015). Induction of the cardiac fate and the proper morphogenesis of the vertebrate heart are controlled by a well-characterized and highly conserved combinatorial network of transcription factors and signaling molecules that act together to orchestrate the embryonic development of the four-chambered mammalian heart and the subsequent post-natal maturation.…”

Section: Introductionmentioning

confidence: 99%

Loss of Asb2 Impairs Cardiomyocyte Differentiation and Leads to Congenital Double Outlet Right Ventricle

Yamak¹,

Hu²,

Mittal³

et al. 2020

iScience

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Defining the pathways that control cardiac development facilitates understanding the pathogenesis of congenital heart disease. Herein, we identify enrichment of a Cullin5 Ub ligase key subunit, Asb2, in myocardial progenitors and differentiated cardiomyocytes. Using two conditional murine knockouts, Nkx +/Cre .Asb2 fl/fl and AHF-Cre.Asb2 fl/fl , and tissue clarifying technique, we reveal Asb2 requirement for embryonic survival and complete heart looping. Deletion of Asb2 results in upregulation of its target Filamin A (Flna), and concurrent Flna deletion partially rescues embryonic lethality. Conditional AHF-Cre.Asb2 knockouts harboring one Flna allele have double outlet right ventricle (DORV), which is rescued by biallelic Flna excision. Transcriptomic and immunofluorescence analyses identify Tgfb/Smad as downstream targets of Asb2/Flna. Finally, using CRISPR/Cas9 genome editing, we demonstrate Asb2 requirement for human cardiomyocyte differentiation suggesting a conserved mechanism between mice and humans. Collectively, our study provides deeper mechanistic understanding of the role of the ubiquitin proteasome system in cardiac development and suggests a previously unidentified murine model for DORV.

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Section: Introductionmentioning

confidence: 99%

Loss of Asb2 Impairs Cardiomyocyte Differentiation and Leads to Congenital Double Outlet Right Ventricle

Yamak¹,

Hu²,

Mittal³

et al. 2020

iScience

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Mechanics of the Left Ventricle in Children Born Prematurely

Pavlyukova,

Kolosova,

Neklyudova

et al. 2023

Fiziologiâ čeloveka

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An increase in the birth rate of premature and low birth weight children at the current level of medical development requires the development of fundamental ideas about the physiology of the cardiovascular system in a history of preterm birth from the point of view of pre- and postnatal ontogenesis. Practicing neonatologists, pediatricians, therapists, cardiologists, reproductologists, etc. it is necessary to improve the traditional ideas about the mechanisms of damage to the cardiovascular system in this category of patients. Because it is established that this clinical subgroup is characterized by increased risks of early onset of pathology of the heart and blood vessels, as well as a high mortality rate in adulthood. Pathological changes of the cardiovascular system in conditions of prematurity can occur at various levels of integration of the body (molecular, subcellular, cellular, organ, functional systems, organismal). The use of modern non-invasive technology “spot trace” makes it possible to study the features of segmental deformation and the variety of forms of LV torsion mechanics during postnatal growth and development in prematurely born children. Optimization of research and diagnostic processes in the field of mechanics of the infant heart in the prenatal and postnatal periods from the point of view of progressive data on anatomy, histology, clinical biochemistry allows us to study the nature of various contractile-rotational models, as well as reasonably assume the contribution of the fibrous skeleton of the infant heart to the formation of “childhood types” of left ventricular twisting. The search and development of informative criteria for the early diagnosis of latent subclinical heart dysfunction in childhood, taking into account the possibilities of non-invasive ultrasound technology “spot trace” (analysis of types of rotational movement, determination of areas of reduced longitudinal deformation of the left ventricle), based on the current provisions of evidence-based medicine, have become quite possible in modern conditions and are demonstrated by the authors in this review. The information offered to the readers will allow to expand the understanding of the physiology and pathophysiology of the infant heart with a history of premature birth, bearing in mind the fact that prematurity is considered a chronic condition.

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Role of Embryonic and Differentiated Cells in Cardiac Development

Cited by 2 publications

References 210 publications

Loss of Asb2 Impairs Cardiomyocyte Differentiation and Leads to Congenital Double Outlet Right Ventricle

Loss of Asb2 Impairs Cardiomyocyte Differentiation and Leads to Congenital Double Outlet Right Ventricle

Mechanics of the Left Ventricle in Children Born Prematurely

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