Role of endocrine disrupting chemicals in children's neurodevelopment

Ramírez, Viviana; Gálvez-Ontiveros, Yolanda; González-Domenech, Pablo José; Baca, Miguel A.; Rodrigo, Lourdes Sánchez; Rivas, Ana

doi:10.1016/j.envres.2021.111890

Cited by 33 publications

(35 citation statements)

References 229 publications

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“…The neurodevelopmental process is vulnerable to environmental stressors, and the cumulative data have shown the neurodevelopmental dysfunctions associated with prenatal exposure to environmental EDCs. , As a kind of EDCs with estrogen-like activities, PFIs were herein found to promote ectoderm development (Figure ) and increase the subsequent neural differentiation characterized by an increased Map2 expression and AChE activity, together with the elevated transcriptional levels of multiple lineage-specific regulatory biomarkers relating to the neural intermediate precursors (Figures , ). The disturbance in the development of three germ layers and neural differentiation was also reported for some other hormones.…”

Section: Discussionmentioning

confidence: 89%

Perfluorinated Iodine Alkanes Promoted Neural Differentiation of mESCs by Targeting miRNA-34a-5p in Notch-Hes Signaling

Ren

Gao

et al. 2022

Environ. Sci. Technol.

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The neurodevelopmental process is highly vulnerable to environmental stress from exposure to endocrine-disrupting chemicals. Perfluorinated iodine alkanes (PFIs) possess estrogenic activities, while their potential neurodevelopmental toxicity remains blurry. In the present study, the effects of two PFIs, including dodecafluoro-1,6-diiodohexane (PFHxDI) and tridecafluorohexyl iodide (PFHxI), were investigated in the neural differentiation of the mouse embryonic stem cells (mESCs). Without influencing the cytobiological process of the mESCs, PFIs interfered the triploblastic development by increasing ectodermal differentiation, thus promoting subsequent neurogenesis. The temporal regulation of PFIs in Notch-Hes signaling through the targeting of mmu-miRNA-34a-5p provided a substantial explanation for the underlying mechanism of PFI-promoted mESC commitment to the neural lineage. The findings herein provided new knowledge on the potential neurodevelopmental toxicities of PFIs, which would help advance the health risk assessment of these kinds of emerging chemicals.

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Section: Discussionmentioning

confidence: 89%

Perfluorinated Iodine Alkanes Promoted Neural Differentiation of mESCs by Targeting miRNA-34a-5p in Notch-Hes Signaling

Ren

Gao

et al. 2022

Environ. Sci. Technol.

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“…Previous studies have shown that the associations of select chemical exposures with neurodevelopmental outcomes are mixture and sex specific [ 6 , 56 , 57 ]. The mechanisms resulting in sex differences have not been fully delineated.…”

Section: Discussionmentioning

confidence: 99%

Childhood exposures to environmental chemicals and neurodevelopmental outcomes in congenital heart disease

Gaynor

Burnham²,

Ittenbach³

et al. 2022

PLoS ONE

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Background Children with congenital heart defects have an increased risk of neurodevelopmental disability. The impact of environmental chemical exposures during daily life on neurodevelopmental outcomes in toddlers with congenital heart defects is unknown. Methods This prospective study investigated the impacts of early childhood exposure to mixtures of environmental chemicals on neurodevelopmental outcomes after cardiac surgery. Outcomes were assessed at 18 months of age using The Bayley Scales of Infant and Toddler Development-III. Urinary concentrations of exposure biomarkers of pesticides, phenols, parabens, and phthalates, and blood levels of lead, mercury, and nicotine were measured at the same time point. Bayesian profile regression and weighted quantile sum regression were utilized to assess associations between mixtures of biomarkers and neurodevelopmental scores. Results One-hundred and forty infants were enrolled, and 110 (79%) returned at 18 months of age. Six biomarker exposure clusters were identified from the Bayesian profile regression analysis; and the pattern was driven by 15 of the 30 biomarkers, most notably 13 phthalate biomarkers. Children in the highest exposure cluster had significantly lower adjusted language scores by -9.41 points (95%CI: -17.2, -1.7) and adjusted motor scores by -4.9 points (-9.5, -0.4) compared to the lowest exposure. Weighted quantile sum regression modeling for the overall exposure-response relationship showed a significantly lower adjusted motor score (β = -2.8 points [2.5th and 97.5th percentile: -6.0, -0.6]). The weighted quantile sum regression index weights for several phthalates, one paraben, and one phenol suggest their relevance for poorer neurodevelopmental outcomes. Conclusions Like other children, infants with congenital heart defects are exposed to complex mixtures of environmental chemicals in daily life. Higher exposure biomarker concentrations were associated with significantly worse performance for language and motor skills in this population.

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“…It was found that higher levels of PBDEs in maternal blood were associated with lower birth weight and higher levels of PCBs, and PFAS were associated with increased birth weight, demonstrating that exposure to these pollutants is already having a negative effect on the health of the population (28). It is important to know that postnatal children's EDCs exposure can cause neurodevelopment effects, these effects are related to the duration of exposure as well as the type of EDC (29). With respect to the importance of the stage of development where the exposure exists, effects of EDCs exposure during puberty are increases in anxious behavior and a reduction in social interaction (30).…”

Section: Environmental and Health Effects Of Edcsmentioning

confidence: 99%

“…28 It is important to know that postnatal children's EDC exposure can cause neurodevelopment effects, and these effects are related to the duration of exposure as well as the type of EDC. 29 With respect to the importance of the stage of development where the exposure exists, the effects of EDC exposure during puberty are increases in anxious behavior and a reduction in social interaction. 30 Additionally, phthalate metabolites were found in the adult population.…”

Section: Environmental and Health Effects Of Edcsmentioning

confidence: 99%

Environmental persistence, detection, and mitigation of endocrine disrupting contaminants in wastewater treatment plants – a review with a focus on tertiary treatment technologies

Rodríguez-Hernández

Araújo

López-Pacheco

et al. 2022

Environ. Sci.: Adv.

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Role of endocrine disrupting chemicals in children's neurodevelopment

Cited by 33 publications

References 229 publications

Perfluorinated Iodine Alkanes Promoted Neural Differentiation of mESCs by Targeting miRNA-34a-5p in Notch-Hes Signaling

Perfluorinated Iodine Alkanes Promoted Neural Differentiation of mESCs by Targeting miRNA-34a-5p in Notch-Hes Signaling

Childhood exposures to environmental chemicals and neurodevelopmental outcomes in congenital heart disease

Environmental persistence, detection, and mitigation of endocrine disrupting contaminants in wastewater treatment plants – a review with a focus on tertiary treatment technologies

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