Role of endogenous Annexin-A1 in the regulation of thymocyte positive and negative selection

Paschalidis, Nikolaos; Huggins, Anthony; Rowbotham, Nicola J.; Furmanski, Anna L.; Crompton, Tessa; Flower, Roderick J.; Perretti, Mauro; D’Acquisto, Fulvio

doi:10.4161/cc.9.4.10673

Cited by 24 publications

(25 citation statements)

References 46 publications

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“…Similar to our findings in mice [65], total human CD4 T cells express about 30% more AnxA1 compared to CD8 and overall significantly lower levels compared to neutrophils or monocytes. Based on our recent studies we hypothesize that the reason behind this difference lays in the different function of this protein in the adaptive immune response.…”

Section: Discussionsupporting

confidence: 91%

“…These receptors recognize a wide variety of structurally unrelated natural and synthetic ligands including the arylcarboxylic acid hydrazide AG-14, the cheno/deoxycholic acid CDCA/DCA, aspirinInternational Immunopharmacology 11 (2011) [55][56][57][58][59][60][61][62][63][64][65][66] triggered lipoxin (ALX), the LL-37 and CCL23β peptides, serum amyloid A (SAA) and the name-giving agonist peptide fMLP [26][27][28]. Seminal studies by Walter et al and other studies have identified the N-terminus derived AnxA1 peptide Ac.2-26 as a ligand for FPR1 [29][30][31].…”

Section: Introductionmentioning

confidence: 99%

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Comparative analysis of Annexin A1-formyl peptide receptor 2/ALX expression in human leukocyte subsets

Spurr

Nadkarni

Pederzoli-Ribeil

et al. 2011

International Immunopharmacology

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Section: Discussionsupporting

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Comparative analysis of Annexin A1-formyl peptide receptor 2/ALX expression in human leukocyte subsets

Spurr

Nadkarni

Pederzoli-Ribeil

et al. 2011

International Immunopharmacology

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“…Moreover, it is unclear whether the effects of AnxA1 on T cell-mediated inflammatory responses arise from effects of AnxA1 expressed specifically by T cells. AnxA1 has been shown to affect activation of several of the myriad signaling pathways associated with T cell activation, including Akt, p38 and ERK MAPK, and NF-kB (17,18,(24)(25)(26)(27). However, these effects have not been observed specifically in CD4 + T cells in the context of Ag-induced activation.…”

mentioning

confidence: 75%

Deficiency of Annexin A1 in CD4+ T Cells Exacerbates T Cell–Dependent Inflammation

Yang

Song

Deane

et al. 2013

The Journal of Immunology

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Annexin A1 (AnxA1) is recognized as an endogenous anti-inflammatory molecule. However, its effects on the adaptive immune response and, in particular, on T cells remain unclear. In this study, we investigated the actions of AnxA1 in three distinct models of T cell–mediated inflammation. In contact hypersensitivity, collagen-induced arthritis, and inflammation induced by OT-II TCR transgenic T cells responding to OVA, AnxA1 deficiency significantly increased Ag-induced T cell proliferation and the resultant level of inflammation. In the contact hypersensitivity model, this was associated with increased adhesion of CD4+ T cells, CD8+ T cells, and neutrophils in the dermal microvasculature, as well as increased T cell expression of RORγt and IL-17A. In collagen-induced arthritis, deficiency of endogenous AnxA1 increased susceptibility to arthritis and Ag-specific T cell activation. Deficiency of AnxA1 also increased OVA-induced cutaneous delayed-type hypersensitivity and IFN-γ and IL-17 release. Transfer experiments using CD4+ T cells from AnxA1−/− mice demonstrated that the absence of AnxA1 solely in T cells resulted in increased inflammatory responses in wild-type recipients. Similarly, experiments using AnxA1−/− OT-II CD4+ T cells demonstrated that the absence of AnxA1 in T cells was sufficient to induce increased Ag-specific CD4+ T cell proliferation in vivo, augment T cell production of IFN-γ, IL-17, TNF, and IL-6, and increase Akt, ERK, and p38 activation. Together, these findings indicate that T cell–expressed AnxA1 functions to attenuate T cell–driven inflammatory responses via T cell–intrinsic effects on intracellular signaling, proliferation, and Th1/Th17 cytokine release.

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“…Anxa1 is a crucial regulator of cell apoptosis and proliferation, inflammatory responses, and lipid metabolism Pupjalis et al 2010;McArthur et al 2010;Paschalidis et al 2010). Accordingly, it is possible that Anxa1 contributes to aging-related β-cell dysfunction; thus, we verified the expression of Anxa1 gene using real-time reverse transcription-polymerase chain reaction (RT-PCR).…”

Section: Real-time Rt-pcrmentioning

confidence: 99%

Effect of aging on islet beta-cell function and its mechanisms in Wistar rats

Liu

et al. 2011

AGE

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Type 2 diabetes mellitus is characterized by islet β-cell dysfunction and its incidence increases with age. However, the mechanisms underlying the effect of aging on islet β-cell function are not fully understood. We characterized β-cell function in 4-month-old (young), 14-monthold (adult), and 24-month-old (old) male Wistar rats, and found that islet β-cell function decreased gradually with age. Old rats displayed oral glucose intolerance and exhibited a decrease in glucosestimulated insulin release (GSIR) and palmitic acid-stimulated insulin release (PSIR). Furthermore, total superoxide dismutase (T-SOD), CuZn superoxide dismutase (CuZn-SOD), and glutathione peroxidase (GSH-Px) activity decreased, whereas serum malondialdehyde (MDA) levels increased in the older rats. Moreover, we detected a significant reduction in β-cell proliferation and an increase in the frequency of apoptotic β-cells in the islets of rats in the old group. Finally, Anxa1 expression in the islets of old rats was significantly upregulated. These data provide new insights into the development of age-related β-cell dysfunction in rats.

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Role of endogenous Annexin-A1 in the regulation of thymocyte positive and negative selection

Cited by 24 publications

References 46 publications

Comparative analysis of Annexin A1-formyl peptide receptor 2/ALX expression in human leukocyte subsets

Comparative analysis of Annexin A1-formyl peptide receptor 2/ALX expression in human leukocyte subsets

Deficiency of Annexin A1 in CD4+ T Cells Exacerbates T Cell–Dependent Inflammation

Effect of aging on islet beta-cell function and its mechanisms in Wistar rats

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