Role of endogenous atrial natriuretic peptide in volume expansion diuresis and natriuresis of the Pekin duck

Gray, David A.

doi:10.1677/joe.0.1400085

Cited by 9 publications

(4 citation statements)

References 16 publications

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“…Another renotropic agent likely to be involved is atrial natriuretic peptide (ANP). The plasma concentration of this hormone is known to be increased by hypervolemia (14) and it has been shown to stimulate renal function in ducks (25) and chickens (13). It has also been shown in mammals (32) that ANG II stimulates ANP release, and so it would obviously be of interest to know whether the circulating concentrations of ANP in the present study were significantly higher in the ANG II-infused animals than in the controls, although it would be difficult to explain why only the kidney responded to the elevated ANP and not the salt glands, which are also known to be stimulated by systemic ANP (16).…”

Section: Discussionmentioning

confidence: 99%

“…A second cannula for collecting blood samples was placed in the other leg and kept patent by an infusion of heparinized (5 U/ml) isotonic saline at a rate of 0.05 ml/min. Silastic tubing was fixed to the nasal nares for the aspiration of salt gland fluid, and a perforated perspex bulb was inserted into the cloaca for urine collection as previously described (14).…”

Section: Preparation Of Animalsmentioning

confidence: 99%

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Role of plasma ANG II in the excretion of acute sodium load in a bird with salt glands (Anas platyrhynchos)

Heinz

Gray

2001

American Journal of Physiology-Regulatory, Integrative and Comp

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This study was designed to further examine the role of plasma ANG II in the excretion of sodium in the Pekin duck, a bird with salt glands. Renal and extrarenal (salt gland) excretion of an intravenously administered isotonic saline load was monitored over a 4-h period in a group of eight birds under two conditions: the control condition, in which isotonic saline infusion decreased endogenous plasma ANG II from 102.6 to 16.5 pg/ml, and the experimental condition, in which ANG II suppression was prevented by intravenous infusion of a 3.5 ng. kg(-1). min(-1) dose of synthetic ANG II. ANG II infusion significantly decreased the total sodium excretion (by 15%), primarily via an inhibition of salt gland output. The results suggest that ANG II suppression facilitates the excretion of an administered sodium load in birds with salt glands.

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Section: Discussionmentioning

confidence: 99%

Section: Preparation Of Animalsmentioning

confidence: 99%

Role of plasma ANG II in the excretion of acute sodium load in a bird with salt glands (Anas platyrhynchos)

Heinz

Gray

2001

American Journal of Physiology-Regulatory, Integrative and Comp

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“…Previous experiments have shown that although saline infusion elevates ANP levels from the basal value, once steady-state renal output has been established, plasma ANP concentrations remain constant (Gray 1994a). The urinary clearance of ANP (UCANP) was calculated according to the formula UCANP=(UANP x V)/PANP, where UCANP is the urinary ANP concentration, V is the urine flow rate and PANP is the plasma concentration of ANP.…”

Section: Statistics and Calculationsmentioning

confidence: 99%

“…Information available about the physiological regulation of atrial natriuretic peptide (ANP) secretion (Gray et al 1991a) as well as its target organ actions (Gregg & Wideman 1986, Schütz et al 1992, Gray 1994a) and interactions with other osmoregulatory hormones (Gray et al 199li), Gray 19946) indicates that this honnone plays a vital role in the maintenance of salt and fluid balance in birds.…”

Section: Introductionmentioning

confidence: 99%

Urinary clearance of atrial natriuretic peptide in Pekin ducks

Gray

1995

Journal of Endocrinology

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To quantify the renal excretion of atrial natriuretic peptide (ANP) in birds, synthetic ANP was infused intravenously into conscious Pekin ducks at rates of 10, 30 and 90 ng/kg per min for 30 min and the relationships between plasma and urine ANP concentrations were monitored by RIA. The infusions of ANP produced dose-dependent elevations in the plasma concentrations of the hormone; however, urinary concentrations and excretion rates did not change significantly from the basal values of 142.2 +/- 21.5 pg/ml and 26.4 +/- 4.5 pg/min per kg respectively. The metabolic clearance rate of ANP remained constant at each infusion dose (approximately 200 ml/min per kg). The urinary clearance rates (< 0.3 ml/min per kg) indicated that the fraction of ANP cleared from the blood via the urine was less than 0.2%. Clearly, excretion of intact ANP via this route is not a quantitatively important means of elimination for this hormone in birds.

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Neuroendocrine Regulation of Hydromineral Homeostasis

Mecawi

Ruginsk

Elias

et al. 2015

Comprehensive Physiology

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Since the crucial evolutionary change from an aqueous to a terrestrial environment, all living organisms address the primordial task of equilibrating the ingestion/production of water and electrolytes (primarily sodium) with their excretion. In mammals, the final route for the excretion of these elements is mainly through the kidneys, which can eliminate concentrated or diluted urine according to the requirements. Despite their primary role in homeostasis, the kidneys are not able to recover water and solutes lost through other systems. Therefore, the selective stimulation or inhibition of motivational and locomotor behavior becomes essential to initiate the search and acquisition of water and/or sodium from the environment. Indeed, imbalances affecting the osmolality and volume of body fluids are dramatic challenges to the maintenance of hydromineral homeostasis. In addition to behavioral changes, which are integrated in the central nervous system, most of the systemic responses recruited to restore hydroelectrolytic balance are accomplished by coordinated actions of the cardiovascular, autonomic and endocrine systems, which determine the appropriate renal responses. The activation of sequential and redundant mechanisms (involving local and systemic factors) produces accurate and self-limited effector responses. From a physiological point of view, understanding the mechanisms underlying water and sodium balance is intriguing and of great interest for the biomedical sciences. Therefore, the present review will address the biophysical, evolutionary and historical perspectives concerning the integrative neuroendocrine control of hydromineral balance, focusing on the major neural and endocrine systems implicated in the control of water and sodium balance.

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Role of endogenous atrial natriuretic peptide in volume expansion diuresis and natriuresis of the Pekin duck

Cited by 9 publications

References 16 publications

Role of plasma ANG II in the excretion of acute sodium load in a bird with salt glands (Anas platyrhynchos)

Role of plasma ANG II in the excretion of acute sodium load in a bird with salt glands (Anas platyrhynchos)

Urinary clearance of atrial natriuretic peptide in Pekin ducks

Neuroendocrine Regulation of Hydromineral Homeostasis

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