1998
DOI: 10.1016/s0167-5273(98)00220-4
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Role of endogenous opioids in syncope induced by head-up tilt test and its relationship with isoproterenol-dependent and isoproterenol-independent neurally-mediated syncope

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Cited by 7 publications
(9 citation statements)
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“…In the present study, the decrease in systolic blood pressure levels during tilt-induced syncope were identical among the three groups. Since the plasma β-endorphin levels were not reported to increase despite tilt-induced hypotension during an isoproterenol provocation tilt test, 6) which correlates with our findings obtained in group 4 in this study, it is unlikely that hypotension and syncope resulted due to a rise in the β-endorphin level. However, further investigation is needed to clarify this question.…”
Section: Discussionsupporting
confidence: 90%
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“…In the present study, the decrease in systolic blood pressure levels during tilt-induced syncope were identical among the three groups. Since the plasma β-endorphin levels were not reported to increase despite tilt-induced hypotension during an isoproterenol provocation tilt test, 6) which correlates with our findings obtained in group 4 in this study, it is unlikely that hypotension and syncope resulted due to a rise in the β-endorphin level. However, further investigation is needed to clarify this question.…”
Section: Discussionsupporting
confidence: 90%
“…However, naloxone, which is a selective β-endorphin inhibitor, could not prevent tilt-induced syncope. 6) These results thus suggest that β-endorphin is not a causative substance. In the present study, the decrease in systolic blood pressure levels during tilt-induced syncope were identical among the three groups.…”
Section: Discussionmentioning
confidence: 83%
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“…Studies on animals and humans showed that endogenous opioids affect sympathetic responses in orthostatic stress by inhibiting their tonic effect, thus inducing syncope. 11,12 Moreover, it was shown that the blockade of opioid receptors modulates sympathetic response and restores glucose production in healthy adults, thus preventing the syndrome of hypoglycemiainduced autonomic failure 13 and exercise-associated autonomic failure. 14 This may suggest that prolonged abuse of high doses of codeine may cause overstimulation of opioid receptors, leading to failure in autonomic neural regulation.…”
Section: Codeine-induced Sensory Neuropathy Autonomic Dysfunction Amentioning
confidence: 99%