Role of endogenous tryptophan during submerged fermentation of ergot alkaloids

Řeháček, Z.; Kozová, J.; Řičicová, A.; Kaslik, J.; Sajdl, P.; Svarc, S; Sc, Basappa

doi:10.1007/bf02887333

Cited by 24 publications

(1 citation statement)

References 11 publications

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“…Interestingly, supplementation with tryptophan has the opposite effect in this fungus (Kalinina et al 2017), in agreement with the notion that indole-3-glycerol phosphate and not tryptophan is the real precursor for IDT biosynthesis (Liu et al 2015). In contrast, tryptophan serves as both a precursor and an inducer for ergot alkaloid biosynthesis in C. purpurea (Řeháček et al 1971). In P. nigricans , penitrem production and sporulation are both induced by calcium chloride (Mantle et al 1984), while CuSO 4 increases penitrem production by P. crustosum (Kalinina et al 2017).…”

Section: Biosynthesis Of Paspaline-derived Idts In Fungimentioning

confidence: 99%

Tremorgenic and neurotoxic paspaline-derived indole-diterpenes: biosynthetic diversity, threats and applications

Kozák

Szilágyi

Tóth

et al. 2019

Appl Microbiol Biotechnol

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Indole-diterpenes (IDTs) such as the aflatrems, janthitrems, lolitrems, paspalitrems, penitrems, shearinines, sulpinines, and terpendoles are biogenetically related but structurally varied tremorgenic and neurotoxic mycotoxins produced by fungi. All these metabolites derive from the biosynthetic intermediate paspaline, a frequently occurring IDT on its own right. In this comprehensive review, we highlight the similarities and differences of the IDT biosynthetic pathways that lead to the generation of the main paspaline-derived IDT subgroups. We survey the taxonomic distribution and the regulation of IDT production in various fungi and compare the organization of the known IDT biosynthetic gene clusters. A detailed assessment of the highly diverse biological activities of these mycotoxins leads us to emphasize the significant losses that paspaline-derived IDTs cause in agriculture, and compels us to warn about the various hazards they represent towards human and livestock health. Conversely, we also describe the potential utility of these versatile molecules as lead compounds for pharmaceutical drug discovery, and examine the prospects for their industrial scale manufacture in genetically manipulated IDT producers or domesticated host microorganisms in synthetic biological production systems.

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Section: Biosynthesis Of Paspaline-derived Idts In Fungimentioning

confidence: 99%

Tremorgenic and neurotoxic paspaline-derived indole-diterpenes: biosynthetic diversity, threats and applications

Kozák

Szilágyi

Tóth

et al. 2019

Appl Microbiol Biotechnol

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Thermodynamic considerations in the formation of ergot alkaloids

Řeháček

Sajdl

Křemen³

1973

Biotech & Bioengineering

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Stamm‐ und milieuspezifische Aminosäuremuster in Claviceps purpurea bei saprophytischer Kultur

Böhmer¹,

Leistner²,

Schlee³

1978

J of Basic Microbiology

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Es wird der Gehalt der freien, mit 80%igem Äthanol extrahierbaren Aminosäuren unter besonderer Berücksichtigung des Prolins mittels automatischer Analyse bestimmt und seine Beziehung zur Synthese der Tripeptidseitenkette der Peptidalkaloide von Claviceps purpurea diskutiert.Wie Versuche mit den Stämmen pepty 695 („Produzent”︁) und pur 221 („Nichtproduzent”︁) bei saprophytischer Kultur auf den Nährlösungen 720 („Produktionsmedium”︁) und M 10 („Nicht‐produktionsmedium”︁) zeigen, sind in Abhängigkeit von der Kulturdauer (1 bis 13 Tage) für die Differenzen im Aminosäuremuster eher Milieubedingungen als Stammspezifika verantwortlich. Mengenmäßig treten die Aminosäuren Ala, γ‐Abu, Glu, Asp, Arg, Lys, Pro und die Säureamide Gln und Asn hervor. Try konnte nicht nachgewiesen werden. In beiden Stämmen wird bei Kultur auf NL 720 Arg zu Kulturende akkumuliert. Der „Nichtproduzent”︁ pur 221 zeichnet sich durch hohe Prolinmengen aus. Unter den gewählten Bedingungen hat der Prolingehalt keine Wirkung auf die Alkaloidausbeute.

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Role of endogenous tryptophan during submerged fermentation of ergot alkaloids

Cited by 24 publications

References 11 publications

Tremorgenic and neurotoxic paspaline-derived indole-diterpenes: biosynthetic diversity, threats and applications

Tremorgenic and neurotoxic paspaline-derived indole-diterpenes: biosynthetic diversity, threats and applications

Thermodynamic considerations in the formation of ergot alkaloids

Stamm‐ und milieuspezifische Aminosäuremuster in Claviceps purpurea bei saprophytischer Kultur

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