Role of Endoscopic Retrograde Cholangiopancreatography in the Diagnosis and Management of Cholestatic Liver Diseases

Keihanian, Tara; Barakat, Monique T.; Tejaswi, Sooraj; Mishra, Ravi Shankar; Carlson, Christopher; Brandabur, John J.; Girotra, Mohit

doi:10.1016/j.cld.2021.08.006

Cited by 2 publications

(1 citation statement)

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“…Brush cytology and biopsy were obtained for anatomopathological analysis, and no atypia were found. cholangioscopy was a highly accurate diagnostic modality for CCA diagnosis with a pooled sensitivity and specificity of 65% (95%CI: 35%-87%) and 97% (95%CI: 87%-99%), respectively [46] . It should state that a negative biopsy does not exclude CCA owing to the possibility of sampling error.…”

Section: Role Of the Endoscopic Testsmentioning

confidence: 96%

Cholangiocarcinoma: early detection and screening in high-risk population

Muñoz-Martínez¹,

Rimola²,

Londoño³

et al. 2022

Hepatoma Res

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Cholangiocarcinoma (CCA) is a highly lethal malignancy that comprises approximately 15% of all the primary liver tumors and 3% of gastrointestinal cancers. Diagnosis is often done when the disease is already at advanced stages, resulting in poor outcomes. Prevention of risk factors and early diagnosis are the cornerstones for improving survival. Early diagnosis is feasible in the setting of surveillance programs in patients at high risk of CCA such as patients with primary sclerosing cholangitis. Regrettably, surveillance of CCA in this population is hampered by the low diagnostic accuracy of current tumor markers at earlier stages, the difficulties of imaging techniques for the differential diagnosis between benign and malignant biliary strictures, and the need for invasive procedures for diagnostic confirmation. In this review we discuss the rationale for surveillance of CCA in high-risk populations, particularly patients with primary sclerosing cholangitis, the recommended tools for surveillance and diagnostic work-up, and future perspectives.

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Section: Role Of the Endoscopic Testsmentioning

confidence: 96%