Role of Endoscopic Ultrasonography and Endoscopic Retrograde Cholangiopancreatography in the Clinical Assessment of Pancreatic Neoplasms

Varadarajulu, Shyam; Bang, Ji Young

doi:10.1016/j.soc.2015.11.004

Cited by 8 publications

(2 citation statements)

References 56 publications

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“…secretion of the cytokine interleukin-6 (IL-6) 64 , has been suggested as a potential biomarker of autophagic activity. Modern clinical procedures such as endoscopic retrograde cholangiopancreatography (ERCP) allow for sampling of such factors from organ associated ducts 65 or the peripheral blood so such an approach is technically feasible. Better understanding of how autophagy regulates secretion, and the molecules secreted, may allow us to incorporate such methods into a biomarker strategy.…”

Section: Biomarkersmentioning

confidence: 99%

Targeting autophagy in cancer

2017

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Preface Autophagy is a mechanism by which cellular material is delivered to lysosomes for degradation allowing basal turnover of cell components and providing energy and macromolecular precursors. Autophagy has opposing, context-dependent roles in cancer and interventions to both stimulate and inhibit autophagy have been proposed as cancer therapies. This has caused therapeutic targeting of autophagy in cancer to be sometimes viewed as controversial. Here we suggest a way forward for effective targeting of autophagy by understanding the context-dependent roles of autophagy and capitalizing on modern approaches to clinical trial design.

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Section: Biomarkersmentioning

confidence: 99%

Targeting autophagy in cancer

2017

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“…Various dedicated aspiration and biopsy needles have been developed over the last two decades, providing a high diagnostic accuracy and high-quality histological core to perform molecular studies. Apart from its diagnostic role, EUS has a therapeutic implication in the management of various aliments associated with pancreatic carcinoma, like celiac plexus neurolysis or RFA (radiofrequency ablation) for pain management, EUS-guided biliary drainage (as a primary modality or rescue therapy), EUS-guided gastrojejunostomy for the management of gastric outlet obstructions, and EUS-guided RFA for locally advanced tumors [ 8 , 9 ]. In this dedicated review, we focus our discussion on the recent advances and the current role of EUS in the diagnosis of PDAC.…”

Section: Introductionmentioning

confidence: 99%

Role of Endoscopic Ultrasound in Diagnosis of Pancreatic Ductal Adenocarcinoma

Chatterjee,

Shah

2023

Diagnostics

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Pancreatic ductal adenocarcinoma (PDAC) is the most common (90%) type of solid pancreatic neoplasm. Due to its late presentation and poor survival rate, early diagnosis and timely treatment is of utmost importance for better clinical outcomes. Endoscopic ultrasound provides high-resolution images of the pancreas and has excellent sensitivity in the diagnosis of even small (<2 cm) pancreatic lesions. Apart from imaging, it also has an advantage of tissue acquisition (EUS fine-needle aspiration, FNA; or fine-needle biopsy, FNB) for definitive diagnoses. EUS-guided tissue acquisition plays a crucial role in genomic and molecular studies, which in today’s era of personalized medicine, are likely to become important components of PDAC management. With the use of better needle designs and technical advancements, EUS has now become an indispensable tool in the management of PDAC. Lastly, artificial intelligence for the detection of pancreatic lesions and newer automated needles for tissue acquisition will obviate observer dependency in the near future, resulting in the wider dissemination and adoption of this technology for improved outcomes in patients with PDAC.

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