Role of endoscopic ultrasound‐guided‐fine needle aspiration biopsy in the diagnosis of lymphoma of the pancreas: A clinicopathological study of nine cases

Sadaf, Safana; Loya, Asif; Akhtar, Noreen; Yusuf, Muhammad

doi:10.1111/cyt.12442

Cited by 17 publications

(24 citation statements)

References 19 publications

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“…Ultrasound-or CT-guided fine-needle biopsy of the pancreatic mass helps to make differential diagnosis. When available, endoscopic ultrasound-guided fineneedle aspiration is an established first-line procedure in the management of solid and cystic pancreatic masses [9]. Acute pancreatitis as a complication of adenocarcinoma of pancreas is well described [10,11].…”

Section: Discussionmentioning

confidence: 99%

Burkitt Lymphoma Mimicking as Pancreas Adenocancer With Liver Metastases

et al. 2017

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Primary lymphomas of the pancreas are uncommon and Burkitt lymphoma (BL) involving pancreas is very rare. It is important to recognize this entity because it can resemble adenocarcinoma of the pancreas but its management is entirely different. We describe a case of synchronous pancreatic, duedonal and liver involvement of BL in a 34-year-old man who presented with acute pancreatitis. Abdominal computed tomography revealed a hypoechogenic area within the head of the pancreas and multiple hypoechogenic areas in the liver. Upper gastrointestinal (GI) endoscopy revealed multiple ulcerated polypoid lesions in the duodenum. Percutaneous fine-needle aspiration biopsy of the liver lesions and endoscopic biopsy of duedonal lesions revealed BL. This is an unusual presentation of BL with pancreatic, duedonal and liver involvement which mimicks as pancreas adenocarcinoma with liver and duedonal metastases.

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Section: Discussionmentioning

confidence: 99%

Burkitt Lymphoma Mimicking as Pancreas Adenocancer With Liver Metastases

et al. 2017

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“…[1][2][3] Common tumours that are diagnosed in pancreas are usually adenocarcinomas. [1][2][3] Common tumours that are diagnosed in pancreas are usually adenocarcinomas.…”

Section: Introductionmentioning

confidence: 99%

“…[1][2][3] Common tumours that are diagnosed in pancreas are usually adenocarcinomas. 1,3,4 With the help of EUS guided FNA, it is possible to extract adequate sample from lesion and make an accurate diagnosis of pancreatic lymphoma without performing a more invasive procedure. EUS guided FNA of pancreatic carcinomas are well known.…”

Section: Introductionmentioning

confidence: 99%

“…Primary pancreatic lymphoma (PPL) is a less common neoplasm of the pancreas comprising of less than 0.5% of all pancreatic tumours. [1][2][3] Common tumours that are diagnosed in pancreas are usually adenocarcinomas. Extranodal NHL of the pancreas is an uncommon entity and can be involved either primarily or can involve the pancreas from adjacent involved intraabdominal lymph node.…”

Section: Introductionmentioning

confidence: 99%

“…3 Pancreatic lymphomas can be treated by chemotherapy and radiotherapy and thus resection can be avoided if a correct diagnosis is made. 1,3,4 With the help of EUS guided FNA, it is possible to extract adequate sample from lesion and make an accurate diagnosis of pancreatic lymphoma without performing a more invasive procedure. Here in this article, we report a case of a 37 year female who was diagnosed as a case of PPL.…”

Section: Introductionmentioning

confidence: 99%

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Primary pancreatic diffuse large B‐cell lymphoma diagnosed by endoscopic ultrasound guided FNAC: A rare entity

Ravi

Stephen

Gochhait

et al. 2019

Diagnostic Cytopathology

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Primary pancreatic lymphoma (PPL) is an uncommon neoplasm which can clinicoradiologically mimic carcinoma. But the management of these patients differs from that of a carcinoma. Endoscopic ultrasound (EUS) guided fine-needle aspiration (FNA) serves as a potential tool to identify pancreatic lymphomas and thus prevent an invasive diagnostic test. This case report describes the presentation and diagnosis of primary pancreatic lymphoma. A 37-year-old female presented with nausea, vomiting with signs of icterus and elevated liver function test and Bilirubin. Abdominal computed tomography (CT) revealed a hypodense lesion in the head of the pancreas. EUS guided FNA was performed and cytological material was collected. The lesion was diagnosed as Non-Hodgkin Lymphoma (NHL) and subtyped as diffuse large B-cell lymphoma-germinal centre (DLBCL-GCB) base on immunohistochemistry on cell block.The patient was started on rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisolone (RCHOP) regimen. EUS guided FNA along with ROSE, cell bock, and immunocytochemistry helps in the diagnosis of primary pancreatic lymphoma. K E Y W O R D Sdiffuse large B-cell lymphoma, endoscopic ultrasound guided, fine-needle aspiration, non-Hodgkin lymphoma, primary pancreatic lymphoma

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Classification of endoscopic ultrasound guided fine needle aspiration cytology of pancreatic space occupying lesions by Papanicolaou Society of Cytopathology System: A five year study

Chaudhary¹,

Banga²,

Sakhuja³

et al. 2022

Diagnostic Cytopathology

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Background: Majority of the pancreatic cancer patients present at an advanced stage and have poor 5 year survival rate. Thus, there is a need for early detection of pancreatic cancer with the initiation of the therapy. Materials& Methods: This is a retrospective study including all the endoscopic ultrasound guided (EUS) guided pancreatic FNAs from 2016 to 2020. The aspirate smears were analyzed and classified according to The Papanicolaou Society of Cytopathology System for Reporting Pancreaticobiliary Cytology (PSCPC).Results: A total of 245 EUS guided FNAs from pancreatic lesions were included.Cyto-histological correlation was done wherever available. Category I (non diagnostic) accounted for 40 cases (16%) cases, Category II (negative) comprised of 44 cases (18%); and Category III (Atypical) had 5 cases (2%). Category IV neoplastic-benign category included 3 cases of serous cystadenoma, while neoplastic-others category included pancreatic neuroendocrine tumors (n = 21), solid pseudo-papillary neoplasms (SPEN) (n = 12) and mucinous cystic neoplasms (n = 4). A total of 7 cases (2.8%) were reported in Category V (Suspicious). A diagnosis of adenocarcinoma (Category VI) was rendered in 105 cases (42.8%) cases. Rarer types included non Hodgkins lymphoma (n = 3) and one case of primary undifferentiated carcinoma with osteoclastic giant cells. Cyto-histological correlation in all categories was available in 58 cases with 8 false negative cases. Thus overall sensitivity of EUS guided FNAC was found to be 87.8% with a diagnostic yield of 83.6% while sensitivity in diagnosing adenocarcinoma was 96.9%. Conclusion:The present study highlights the spectrum of EUS guided FNA of pancreatic lesions in a subset of North Indian population and classified them according to PSCPC. EUS guided FNAC is a sensitive investigation which plays a crucial role in confirming the diagnosis of pancreatic space occupying lesions (SOLs) in advanced stage.

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Role of endoscopic ultrasound‐guided‐fine needle aspiration biopsy in the diagnosis of lymphoma of the pancreas: A clinicopathological study of nine cases

Abstract: EUS-FNA in experienced hands is a valuable diagnostic modality, in conjunction with ROSE, immunohistochemistry and flow cytometry, in the diagnosis and sub-typing of both primary and secondary pancreatic lymphoma.

Cited by 17 publications

References 19 publications

Burkitt Lymphoma Mimicking as Pancreas Adenocancer With Liver Metastases

Burkitt Lymphoma Mimicking as Pancreas Adenocancer With Liver Metastases

Primary pancreatic diffuse large B‐cell lymphoma diagnosed by endoscopic ultrasound guided FNAC: A rare entity

Classification of endoscopic ultrasound guided fine needle aspiration cytology of pancreatic space occupying lesions by Papanicolaou Society of Cytopathology System: A five year study

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