Role of endothelial‑microparticles and the tissue factor pathway in ginsenoside Rb1‑mediated prevention of umbilical vein endothelial cell injury

Zhao, Miaomiao; Xie, Juan; Shen, Haorui; Wang, Xiaoxiao; Wu, Qirui; Xia, Linghui

doi:10.3892/br.2020.1384

Cited by 7 publications

(3 citation statements)

References 37 publications

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“…Though, during systemic inflammation and dysregulation of RAS, the expression of TF by the endothelial cells is augmented (Reeves et al 2018). TF induces coagulation cascade as it act as a receptor for clotting factor VII (Zhao et al 2021). TF is modulated by many endogenous proteinases expressed on the endothelial cells, called TF pathway inhibitor (TFPI) (Zhao et al 2021).…”

Section: Heparanase In Covid-19mentioning

confidence: 99%

“…TF induces coagulation cascade as it act as a receptor for clotting factor VII (Zhao et al 2021). TF is modulated by many endogenous proteinases expressed on the endothelial cells, called TF pathway inhibitor (TFPI) (Zhao et al 2021). Therefore, activation of TF and TFPI trigger development of thrombosis in severe viral infections and cancer (Zhao et al 2021).…”

Section: Heparanase In Covid-19mentioning

confidence: 99%

“…TF is modulated by many endogenous proteinases expressed on the endothelial cells, called TF pathway inhibitor (TFPI) (Zhao et al 2021). Therefore, activation of TF and TFPI trigger development of thrombosis in severe viral infections and cancer (Zhao et al 2021). Over-expression of HPSE and degradation of HS can cause coagulopathy through induction expression of TF and TFPI (Kinaneh et al 2021).…”

Section: Heparanase In Covid-19mentioning

confidence: 99%

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Heparanase is the possible link between monkeypox and Covid-19: robust candidature in the mystic and present perspective

Al-Kuraishy¹,

Al-Gareeb²,

Hetta

et al. 2023

AMB Expr

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Heparanase (HPSE) is an endoglycosidase cleaves heparan sulfate (HS) and this contributes to the degradation and remodeling of the extracellular matrix. HS cleaved by HPSE induces activation of autophagy and formation of autophagosommes which facilitate binding of HPSE to the HS and subsequent release of growth factors. The interaction between HPSE and HS triggers releases of chemokines and cytokines which affect inflammatory response and cell signaling pathways with development of hyperinflammation, cytokine storm (CS) and coagulopathy. HPSE expression is induced by both SARS-CoV-2 and monkeypox virus (MPXV) leading to induction release of pro-inflammatory cytokines, endothelial dysfunction and thrombotic events. Co-infection of MPX with SARS-CoV-2 may occur as we facing many outbreaks of MPX cases during Covid-19 pandemic. Therefore, targeting of HPSE by specific inhibitors may reduce the risk of complications in both SARS-CoV-2 and MPXV infections. Taken together, HPSE could be a potential link between MPX with SARS-CoV-2 in Covid-19 era.

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Section: Heparanase In Covid-19mentioning

confidence: 99%

Section: Heparanase In Covid-19mentioning

confidence: 99%

Section: Heparanase In Covid-19mentioning

confidence: 99%

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Heparanase is the possible link between monkeypox and Covid-19: robust candidature in the mystic and present perspective

Al-Kuraishy¹,

Al-Gareeb²,

Hetta

et al. 2023

AMB Expr

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HPV16 E6 promoting cervical cancer progression through down‐regulation of miR‐320a to increase TOP2A expression

Zhang,

Yu,

Guo

et al. 2024

Cancer Medicine

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BackgroundCervical cancer (CC) has become the fourth most common cancer worldwide and it is mainly caused by the infection of human papillomavirus (HPV), especially high‐risk HPV16. Aberrant miRNA expression in CC is closely related to HPV16 infection, and the regulation of HPV16 E6 expression can affect a variety of miRNA expression. This study aims to exploring the miRNAs involved in E6 regulation in CC.MethodsOur study screened differentially expressed miRNAs in cervical cells of HPV16 infected and uninfected cervical cancer patients by analyzing the GSE81137 dataset of the gene expression omnibus database (GEO), and identified miR‐320a that plays an anti‐tumor role and is associated with good prognosis of cervical cancer. Explore the effect of HPV16 E6 on the expression of miR‐320a in cervical cancer, and verify whether HPV16 E6 regulates the downstream target gene TOP2A expression through miR‐320a, thereby affecting cervical cancer cell proliferation, apoptosis, migration, invasion, and EMT in vitro and in vivo.ResultsThe bioinformatic methods selected the miR‐320a, which was differentially expressed in cervical cells from HPV16‐infected patients compared to uninfected patients. We further demonstrated that miR‐320a level was regulated by HPV16 E6, which promoted the CC cell proliferation, migration, invasion, and inhibited apoptosis. In addition, we predicted the downstream target genes of miR‐320a and confirmed that TOP2A was one of its targeting proteins. Moreover, HPV16 E6 promoted the TOP2A expression in CC cells through down‐regulating miR‐320a, leading to promoting CC development.ConclusionsWe confirmed that HPV16 E6 promoted the TOP2A expression through down‐regulation of miR‐320a, thus promoting CC development, and the HPV16 E6/miR‐320a/TOP2A axis may perform as a potential target for CC treatment.

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Prioritizing the candidate genes related to cervical cancer using the moment of inertia tensor

et al. 2021

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It is well known that cervical cancer poses the fourth most malignancy threat to women worldwide among all cancer types. There is a tremendous improvement in realizing the underlying molecular associations in cervical cancer. Several studies reported pieces of evidence for the involvement of various genes in the disease progression. However, with the ever-evolving bioinformatics tools, there has been an upsurge in predicting numerous genes responsible for cervical cancer progression and making it highly complex to target the genes for further evaluation. In this article, we prioritized the candidate genes based on the sequence similarity analysis with known cancer genes. For this purpose, we used the concept of the moment of inertia tensor, which reveals the similarities between the protein sequences more efficiently.Tensor for moment of inertia explores the similarity of the protein sequences based on the physicochemical properties of amino acids. From our analysis, we obtained 14 candidate cervical cancer genes, which are highly similar to known cervical cancer genes. Further, we analyzed the GO terms and prioritized these genes based on the number of hits with biological process, molecular functions, and their involvement in KEGG pathways. We also discussed the evidence-based involvement of the prioritized genes in other cancers and listed the available drugs for those genes.

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Role of endothelial‑microparticles and the tissue factor pathway in ginsenoside Rb1‑mediated prevention of umbilical vein endothelial cell injury

Cited by 7 publications

References 37 publications

Heparanase is the possible link between monkeypox and Covid-19: robust candidature in the mystic and present perspective

Heparanase is the possible link between monkeypox and Covid-19: robust candidature in the mystic and present perspective

HPV16 E6 promoting cervical cancer progression through down‐regulation of miR‐320a to increase TOP2A expression

Prioritizing the candidate genes related to cervical cancer using the moment of inertia tensor

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