Role of Endothelium in the Development of Pulmonary Hypertension

Ross, Bryan; Giaid, Adel

doi:10.1007/978-0-387-87429-6_58

Cited by 1 publication

(1 citation statement)

References 87 publications

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“…While several pathways, such as platelet-derived growth factor (PDGF) [93] or nitric oxide (NO) [94] signaling, have been previously implicated in the pathogenesis of PAH, very recently data has emerged that also support a role for MR in this disease. In three distinct experimental rodent models of pulmonary hypertension, MR antagonism attenuates the severity of the PAH phenotype [78, 95].…”

Section: The Role Of Mr In Pulmonary Arterial Hypertensionmentioning

confidence: 99%

Mineralocorticoid Receptors in Vascular Disease: Connecting Molecular Pathways to Clinical Implications

McGraw

McCurley

Preston

et al. 2013

Curr Atheroscler Rep

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The mineralocorticoid receptor (MR), a steroid hormone-activated transcription factor, plays a substantial role in cardiovascular diseases. MR antagonists (MRAs) have long been appreciated as effective treatments for heart failure and hypertension; however, recent research suggests that additional patient populations may also benefit from MRA therapy. Experimental evidence demonstrates that in addition to its classical role in the regulating sodium handling in the kidney, functional MR is expressed in the blood vessels and contributes to hypertension, vascular inflammation and remodeling, and atherogenesis. MR activation drives pathological phenotypes in smooth muscle cells, endothelial cells and inflammatory cells, while MRAs inhibit these effects.Collectively, these studies demonstrate a new role for extra-renal MR in cardiovascular disease. This review summarizes these new lines of evidence and how they contribute to mechanisms of atherosclerosis, pulmonary and systemic hypertension, and vein graft failure, and describes new patient populations that may benefit from MRA therapy.

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