2013
DOI: 10.1128/iai.00750-13
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Role of Energy Sensor TlpD of Helicobacter pylori in Gerbil Colonization and Genome Analyses after Adaptation in the Gerbil

Abstract: cHelicobacter pylori maintains colonization in its human host using a limited set of taxis sensors. TlpD is a proposed energy taxis sensor of H. pylori and dominant under environmental conditions of low bacterial energy yield. We studied the impact of H. pylori TlpD on colonization in vivo using a gerbil infection model which closely mimics the gastric physiology of humans. A gerbil-adapted H. pylori strain, HP87 P7, showed energy-dependent behavior, while its isogenic tlpD mutant lost it. A TlpD-complemented … Show more

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Cited by 32 publications
(57 citation statements)
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References 90 publications
(173 reference statements)
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“…tlpD mutants are substantially affected in their ability to colonize the stomach at early time points (7,8), presumably because tlpD-deficient strains are unable to sense signals that are generated by exposure to the host environment and are therefore unable to locate a preferred niche in the stomach. At later time points, colonization defects due to chemotaxis and TlpD are less apparent (16,18).…”
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confidence: 99%
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“…tlpD mutants are substantially affected in their ability to colonize the stomach at early time points (7,8), presumably because tlpD-deficient strains are unable to sense signals that are generated by exposure to the host environment and are therefore unable to locate a preferred niche in the stomach. At later time points, colonization defects due to chemotaxis and TlpD are less apparent (16,18).…”
mentioning
confidence: 99%
“…TlpD plays a critical role during H. pylori infection of the mammalian stomach (7,8). In wild-type mice or gerbils, mutant strains of H. pylori that lack TlpD display colonization defects during the early stages of infection that are more severe than those of mutant strains that lack any other individual chemoreceptor (7,8).…”
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confidence: 99%
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“…Furthermore, chemoreceptors can function in processes other than motility, e.g., gene regulation (8). Cytoplasmic chemoreceptors, however, are known to play important roles in many microbial processes, including pathogenesis (9,10), fruiting body formation (8), as well as mediating taxis in response to cellular energy stores (11,12), redox (13,14), and metabolites (15). In this review, we first start with a discussion of basic chemoreceptor attributes and then summarize the current state of understanding about signal recognition, signal transduction, and the subcellular localization of cytoplasmic chemoreceptors.…”
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confidence: 99%