Role of ENPP1 Gene Variants in the Susceptibility to Diabetic Nephropathy in Patients with type 2 Diabetes Mellitus

Faraji, Niloofar; Abbaspour, S.; Ajamian, Farzam; Keshavarz, Parvaneh

doi:10.1007/s10528-023-10402-z

Cited by 2 publications

(1 citation statement)

References 43 publications

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“…The most notable increase in diabetes prevalence has been observed in middle-income countries [ 1 , 2 ]. Both genetics and epigenetics play a significant role in the onset of diabetes and following clinical and daily life complications [ 3 , 4 ]. The predictive efficacy of obesity-related variables for diabetes onset may vary across ethnicities, age groups, and genders, highlighting the role of both genetics and epigenetics in vulnerability to diabetes [ 5 , 6 ].…”

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confidence: 99%

The association between waist-to-hip ratio (WHR) with diabetes in the PERSIAN Guilan cohort study population

Aghaei,

Joukar,

Hasanipour

et al. 2024

BMC Endocr Disord

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Background Waist circumference (WC), or waist-to-hip ratio (WHR), potentially offers a more accurate reflection of intra-abdominal fat accumulation and could serve as a superior predictor of type 2 diabetes mellitus (T2DM) risk compared to BMI. The current study investigated the relationship between WHR and its influencing factors among diabetes patients enrolled in the Prospective Epidemiological Research Studies in Iran (PERSIAN) Guilan Cohort study (PGCS). Method In this cross-sectional study of 10,520 participants, 2,531 had T2DM. Waist and hip circumference, body mass index (BMI), underlying diseases, and demographical data of participants were recorded. Also, fasting blood sugar (FBS), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, and triglycerides (TG) were assessed. All data was analyzed using SPSS version 16; the significant level was < 0.05. Results The mean age of participants was 51.52 ± 8.90 years, and 39.9% had a BMI between 25 and 30 kg/m2. The prevalence of diabetes was 24.1% (n = 2531). About 7628 (72.5%) individuals had abnormal WHR, and 2072 (19.7%) were diabetics. Among patients with diabetes, abnormal WHR was significantly associated with age over 50, female gender, higher BMI, and lower LDL (P < 0.05). Conclusion The study showed a higher prevalence of abnormal WHR in diabetic patients. Abnormal WHR in patients with diabetes was significantly associated with age, gender, and BMI.

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Section: Introductionmentioning

confidence: 99%

The association between waist-to-hip ratio (WHR) with diabetes in the PERSIAN Guilan cohort study population

Aghaei,

Joukar,

Hasanipour

et al. 2024

BMC Endocr Disord

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Research Progress on the Hypoglycemic Effects and Mechanisms of Action of Momordica charantia polysaccharide

Liu,

Lei,

Guo

et al. 2023

Journal of Food Biochemistry

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With the improvement of living standards, the number of people diagnosed with diabetes is increasing, leading to diabetes-related expenditures reaching billions of dollars. Finding a simple, convenient, effective, and long-lasting drug for the treatment of diabetes is urgent. Bitter melon has a history of thousands of years of consumption and medicinal use in China, with numerous health benefits, including the prevention and treatment of diabetes, promotion of appetite, improvement of eyesight, aid in digestion, detoxification, and diuretic effects, earning it the title of “medicinal vegetable.” Momordica charantia polysaccharide (MCP) is a type of heteropolysaccharide extracted from bitter melon fruit, which is an important component of bitter melon and has multiple biological functions, particularly in the treatment of type 1 and type 2 diabetes. This article summarizes the research results on the use of MCP in the treatment of diabetes over the past 20 years, using data from various databases, including PubMed, Web of Science, Science Direct, Springer, Wiley, ACS, and CNKI, as well as doctoral and master’s theses. The article discusses the most commonly used methods and techniques for extracting, isolating, and purifying MCP. It also explores the extraction methods, molecular weight, monosaccharide composition, and structural characteristics of MCP and provides a detailed account of the hypoglycemic effects of MCP in cell models, animal models, and human experiments. This review lays the foundation for the further development and application of MCP.

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Role of ENPP1 Gene Variants in the Susceptibility to Diabetic Nephropathy in Patients with type 2 Diabetes Mellitus

Cited by 2 publications

References 43 publications

The association between waist-to-hip ratio (WHR) with diabetes in the PERSIAN Guilan cohort study population

The association between waist-to-hip ratio (WHR) with diabetes in the PERSIAN Guilan cohort study population

Research Progress on the Hypoglycemic Effects and Mechanisms of Action of Momordica charantia polysaccharide

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