Role of environmental and genetic factors in autism spectrum disorder

Sultana, Zakia; Uddin, Sarder Nasir; Ahmed, Asif

doi:10.3329/bsmmuj.v10i2.32385

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…Children with autistic disorders have limitations in their development, such as social difficulties, language and speech delays, and behavioral problems. This neurological disorder can be seen from the abnormal EEG and MRI results (Sultana et al, 2017).…”

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confidence: 99%

Meta Analysis: Effects of Polycystic Ovarian Syndrome and Maternal Diabetes on the Risk of Autism in Children

Sukmakarti,

Murti,

Adriani

2023

J Matern Child Health

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Background: Autism is a condition of developmental abnormalities in social, communication and behavior aspects. Polycystic ovary syndrome and maternal diabetes during pregnancy contribute more than 50% to the risk of ASD offspring. This study aims to analyze and estimate the influence of polycystic ovarian syndrome and maternal diabetes on autism in children. Subjects and Method: The meta-analysis was carried out according to the PRISMA flow chart and the PICO model. Q: Child, I: Mother with PCOS and maternal diabetes, C: T Mother without PCOS and maternal diabetes, O: Autism. Search for articles in this study through databases that include Google Scholar, Pubmed, ScienceDirect and Sage Journal. With keywords including: Polycystic Ovarian Syndrome” AND “Maternal Diabetes” OR “Gestational Diabetes Mellitus” AND “Autism” OR “Autism Spectrum Disorder” AND “Cohort”. A full paper article with an observational cohort study, the research subject was a child, the size of the relationship used was the adjusted odds ratio, the research outcome was autism. Analysis was performed with Revman 5.3. Results: There were 13 articles with cohort designs originating from America, Denmark, England, Sweden, Israel, China with a total of 4,641,483 research samples. A meta-analysis of 13 cohort studies concluded that children of pregnant women with PCOS had a 1.36 times greater risk of developing autism than those without PCOS, and the effect was statistically significant (aOR= 1.36; 95% CI= 1.24 to 1.49; p<0.001). In addition, pregnant women with maternal diabetes have a 1.24 times higher risk of having a child with autism than those without maternal diabetes, and this effect is statistically significant (aOR= 1.24; 95% CI= 1.08 to 1.43; p=0.002). Conclusion: Pregnant women who have PCOS and maternal diabetes increase the risk of autism in children. Keywords: polycystic ovarian syndrome, maternal diabetes, autism.

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confidence: 99%