Role of environmental exposure to spider mites in the sensitization and the clinical manifestation of asthma and rhinitis in children and adolescents living in rural and urban areas

Abstract

Spider mites are common sensitizing allergens in children and adolescents exposed to them, and environmental exposure to these mites may represent an important risk factor in the sensitization and the clinical manifestations of asthma and rhinitis in children and adolescents living in rural and urban areas.

Multilocus analysis of atopy in Korean children using multifactor-dimensionality reduction

“…Skin prick testing with 11 common aeroallergens (Dermatophagoides pteronyssinus, D farinae, dog fur, cat fur, Aspergillus, Alternaria, tree pollen mixture, grass pollen mixture, mugwort, ragweed and cockroach; Allergopharma, Reinbeck, Germany) was performed as described previously. 9 Participants who had received oral antihistamines during the 5 days before the skin prick test or had dermographism were excluded. Atopy was defined as a positive skin prick test response (allergen/histamine ratio .1 and a mean weal size .4 mm) to one or more allergens.…”

Association between genetic variations of vascular endothelial growth factor receptor 2 and atopy in the Korean population

“…17 Methacholine AHR was expressed as PC 20 and was regarded as positive if the PC 20 was less than 16 mg/mL. Skin prick testing to 11 common aeroallergens (Allergopharma, Reinbek, Germany) was performed, as previously described, 3 to evaluate T H 2 sensitization to allergens. Subjects who had received oral antihistamines during the 5 days before skin prick testing or had dermographism were excluded from the skin prick testing.…”

“…2 Atopy is defined as a genetic predisposition to an enhanced IgE response to common environmental allergens and is considered to be the factor that most strongly predisposes an individual to asthma development. 3 On the other hand, AHR is believed to be an essential component of asthma development and can be used to differentiate asthma and other airway diseases. 4 Vascular endothelial growth factor (VEGF) was originally described as a vascular permeability factor because of its ability to generate tissue edema.…”

Association between genetic variations of the transforming growth factor β receptor type III and asthma in a Korean population

“…Subjects who had received oral antihistamines during the five days prior to skin prick testing or had dermographism were excluded from the skin prick testing. A total of 2,047 subjects underwent skin prick testing against 11 common aeroallergens (Allergopharma, Germany) as previously described (Kim et al, 2002). Atopy was defined as a positive skin prick test response (allergen/histamine ratio ＞1.0 plus a mean wheal size ＞4 mm) to one or more allergens.…”

“…Asthma is a complex phenotype that is clinically difficult to define. This difficulty is associated with intermediate phenotypes, such as atopy and AHR, that have provided useful objective alternatives in genetic and epidemiologic studies (Wiesch et al, 1999;Kim et al, 2002;Townley and Horiba, 2003).…”