Role of environmental stresses in elevating resistance mutations in bacteria: Phenomena and mechanisms

Wang, Dali; Ning, Qing; Deng, Ziqing; Zhang, Meng; You, Jing

doi:10.1016/j.envpol.2022.119603

Cited by 23 publications

(16 citation statements)

References 166 publications

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“…Two observations can be made from the results obtained: firstly, the Progreso sampling site, positioned within one of the five most densely populated cities in Yucatan and thus influenced by significant human activities, exhibits a notably higher abundance of mobile elements when compared to the other sites ( Fig 1A ). The findings suggests that HGT plays an important role in conferring tolerance to various contaminants to the bacterial communities present in mangroves affected by pollution processes [ 5 , 46 ]. Furthermore, these observations suggests that polluted mangroves are areas of high transfer of genetic information between bacterial species through MGEs.…”

Section: Discussionmentioning

confidence: 99%

“…This functional diversity derives from the plasticity of its genome, which is enriched not only by the transfer of genetic material from parents to daughter cells, but also by transfer of genetic information between individuals, in an ancient process called Horizontal Gene Transfer (HGT) [ 1 – 3 ]. HGT has been documented as a general strategy that stimulates adaptability to adverse environmental conditions, providing a set of molecular functions that facilitate the survival of bacterial species and their communities [ 4 , 5 ]. HGT has been associated with the spread of a group of conserved genetic elements known as Mobile Genetic Elements (MGEs) within bacterial communities [ 6 , 7 ].…”

Section: Introductionmentioning

confidence: 99%

“…Mangroves and coasts represent highly dynamic ecosystems, and the organisms present in these places are constantly exchanging information, molecules and signals to face and adapt to a wide variety of environmental and pollution factors [ 20 , 21 ]. Among the adaptive traits that MGEs gives to the bacterial communities present in the mangroves are genes encoding antibiotic and heavy metals resistance, as well as xenobiotic degradation genes [ 5 , 22 , 23 ], and this is stimulate by the selective pressure exercised by contamination.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Geographical distribution of mobile genetic elements in microbial communities along the Yucatan coast

Guillén-Chable,

Valdez Iuit,

Avila Castro

et al. 2024

PLoS ONE

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Horizontal gene transfer (HGT) is a well-documented strategy used by bacteria to enhance their adaptability to challenging environmental conditions. Through HGT, a group of conserved genetic elements known as mobile genetic elements (MGEs) is disseminated within bacterial communities. MGEs offer numerous advantages to the host, increasing its fitness by acquiring new functions that help bacteria contend with adverse conditions, including exposure to heavy metal and antibiotics. This study explores MGEs within microbial communities along the Yucatan coast using a metatranscriptomics approach. Prior to this research, nothing was known about the coastal Yucatan’s microbial environmental mobilome and HGT processes between these bacterial communities. This study reveals a positive correlation between MGEs and antibiotic resistance genes (ARGs) along the Yucatan coast, with higher MGEs abundance in more contaminated sites. The Proteobacteria and Firmicutes groups exhibited the highest number of MGEs. It’s important to highlight that the most abundant classes of MGEs might not be the ones most strongly linked to ARGs, as observed for the recombination/repair class. This work presents the first geographical distribution of the environmental mobilome in Yucatan Peninsula mangroves.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Geographical distribution of mobile genetic elements in microbial communities along the Yucatan coast

Guillén-Chable,

Valdez Iuit,

Avila Castro

et al. 2024

PLoS ONE

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“…Simultaneously, high mutation rates have been associated with biofilms [132], specifically in persister populations [133], hence increasing the chances of acquiring genetic resistances. This could be due to the use of error-prone polymerases during the SOS response, which ultimately leads to higher probability of mutational events and fixation of some resistance mechanisms [134,135].…”

Section: From Physiological Adaptation To Genetic Resistancementioning

confidence: 99%

Biofilms as protective cocoons against biocides: from bacterial adaptation to One Health issues

et al. 2023

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Bacteria in the food chain mostly live in communities associated with surfaces known as biofilms, which confer specific survival and adaptive abilities. In such communities, the bacteria mostly exhibit higher tolerance to external stress, and their recurrent exposure along the food chain to biocides used during cleaning and disinfection procedures raises concern about the adaptation routes they develop, both at single-cell and communal levels. In recent years, an increasing number of research subjects have focused on understanding the specific features of biofilms that enable bacterial populations to adapt to biocide exposure within a ‘protective cocoon’. The first part of this review concentrates on the diversity of adaptive strategies, including structural modulation of these biofilms, physiological response or the acquisition of genetic resistance. The second part discusses the possible side effects of biofilm adaptation to biocides on antimicrobial cross-resistance, virulence and colonization features from a One Health perspective.

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“…Due to their role in a number of infectious diseases that can be fatal, multidrug-resistant bacteria pose a severe threat to public health globally [11]. Pollution, mutation, changing environmental circumstances, and excessive drug Microorganisms 2023, 11, 945 2 of 21 usage all contribute to the ongoing rise in multidrug-resistant bacterial species [12,13]. To solve this issue, researchers are working to create novel medications for the treatment of these microbial illnesses [14].…”

Section: Introductionmentioning

confidence: 99%

Green Biofabrication of Silver Nanoparticles of Potential Synergistic Activity with Antibacterial and Antifungal Agents against Some Nosocomial Pathogens

et al. 2023

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Nosocomial bacterial and fungal infections are one of the main causes of high morbidity and mortality worldwide, owing to the high prevalence of multidrug-resistant microbial strains. Hence, the study aims to synthesize, characterize, and investigate the antifungal and antibacterial activity of silver nanoparticles (AgNPs) fabricated using Camellia sinensis leaves against nosocomial pathogens. The biogenic AgNPs revealed a small particle diameter of 35.761 ± 3.18 nm based on transmission electron microscope (TEM) graphs and a negative surface charge of −14.1 mV, revealing the repulsive forces between nanoparticles, which in turn indicated their colloidal stability. The disk diffusion assay confirmed that Escherichia coli was the most susceptible bacterial strain to the biogenic AgNPs (200 g/disk), while the lowest sensitive strain was found to be the Acinetobacter baumannii strain with relative inhibition zones of 36.14 ± 0.67 and 21.04 ± 0.19 mm, respectively. On the other hand, the biogenic AgNPs (200 µg/disk) exposed antifungal efficacy against Candida albicans strain with a relative inhibition zone of 18.16 ± 0.14 mm in diameter. The biogenic AgNPs exposed synergistic activity with both tigecycline and clotrimazole against A. baumannii and C. albicans, respectively. In conclusion, the biogenic AgNPs demonstrated distinct physicochemical properties and potential synergistic bioactivity with tigecycline, linezolid, and clotrimazole against gram-negative, gram-positive, and fungal strains, respectively. This is paving the way for the development of effective antimicrobial combinations for the effective management of nosocomial pathogens in intensive care units (ICUs) and health care settings.

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Role of environmental stresses in elevating resistance mutations in bacteria: Phenomena and mechanisms

Cited by 23 publications

References 166 publications

Geographical distribution of mobile genetic elements in microbial communities along the Yucatan coast

Geographical distribution of mobile genetic elements in microbial communities along the Yucatan coast

Biofilms as protective cocoons against biocides: from bacterial adaptation to One Health issues

Green Biofabrication of Silver Nanoparticles of Potential Synergistic Activity with Antibacterial and Antifungal Agents against Some Nosocomial Pathogens

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