Role of eosinopenia in predicting mortality and morbidity in patients with Chronic Obstructive Pulmonary Disease (COPD)

Ali, Abdi; Ibrahim, Javed; Khan, Tanjila; Ahmed, Jamal Uddin; Sesan, Akinyemi; Crawford, Emma; Srinivasan, Koottalai; Moudgil, Harmesh; Makan, Abdelhadi; Ahmad, Naveed

doi:10.1183/13993003.congress-2019.pa2576

Cited by 2 publications

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“…Studies have linked low eosinophil counts to an increased risk of death, greater frequency of hospitalisation, and a more virulent strain of bacteria. [12] Since chest infection is not only a major risk factor in COPD exacerbation but also regarded a main cause of mortality in these patients, there is a substantial difference in consolidation between the surviving and dead groups (47.62 percent and 87.50 percent, P = 0.038). Multiple studies showed that it was an effective mortality predictor and that it influenced risk rating methods.…”

Section: Fig 3: Receiver Operator Characteristic Curve For Need For M...mentioning

confidence: 99%

(BAP65) Score versus (DECAF) Score in Assessment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Hassan¹,

Abdelhamed

Fekry

2023

Benha Journal of Applied Sciences

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A common, preventable, and treatable disease characterised by persistent respiratory symptoms and airflow limitation due to airway and/or alveolar abnormalities, typically resulting from extensive exposure to noxious particles or gases, and influenced by host factors including abnormal lung development is Chronic Obstructive Pulmonary Disease (COPD). The purpose of this research was to compare the previously established BAP65 score to the newly developed DECAF score for its ability to predict mortality and the requirement for IMV in patients admitted to the intensive care unit with AECOPD. Methods: Fifty people with COPD exacerbation were included in this research from our emergency rooms and intensive care units at Benha University. Comparison of BAP 65 score components between survivors and patients who passed away revealed statistically significant differences for BUN >25 (21.43 percent in the discharged group versus 62.50 percent in the died group, P = 0.018), Altered mental status (11.90 percent in the discharged group versus 50.00 percent in the died group, P = 0.026), and pulse >109 bpm (21.43 percent in the discharged group versus 75.00 percent in the died group, P = 0.002). Ages >65 did not significantly differ between the two groups (40.48 percent in the discharged group vs 75.00 percent in the dying group, P = 0.073). Conclusions: COPD is a severe health disease that affects patient health and life, and represents a burden for the health services. The mean value of BAP 65 score was 2.191.04 in the discharged group, and 3.751.58 in the deceased group, with a very significant difference between groups (P= 0.001). Early identification and adequate care of COPD improves patient prognosis since exacerbations are the leading cause of death in COPD patients. A patient's prognosis during AECOPD may be evaluated using not just clinical judgement, but also the BAP65 and DECAF scoring systems, which take into account a variety of parameters.

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Section: Fig 3: Receiver Operator Characteristic Curve For Need For M...mentioning

confidence: 99%

(BAP65) Score versus (DECAF) Score in Assessment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Hassan¹,

Abdelhamed

Fekry

2023

Benha Journal of Applied Sciences

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Eosinophil count: a predictor of in-hospital mortality in a cohort of cirrhosis patients with sepsis

Anoop

Devadas

Varghese

2022

Egypt Liver Journal

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Background Declining eosinophil count has recently been associated with sepsis. Thus, absolute eosinophil count (AEC) can be used as a marker of the severity of sepsis, which helps in the early identification of high-risk patients, and better management can be offered to such patients. The aim of this study was to assess whether AEC at the time of ICU admission can be used as a predictor of in-hospital mortality in cirrhotics with sepsis. Results This was a retrospective study which was conducted in 105 cirrhotic patients admitted with sepsis in the Department of Gastroenterology, Medical College Trivandrum, from May 2014 to October 2014. Every consecutive patient with cirrhosis and sepsis (defined as systemic inflammatory response syndrome (SIRS) and the presence of infections) admitted to the ICU/high dependency unit was recruited for the study. Among the various parameters analyzed, model for end-stage liver disease (MELD) score, Child-Pugh Turcot (CTP) score, albumin levels, total count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), alanine aminotransferase (ALT), bilirubin, creatinine, urea, and absolute eosinophil count were statistically significant in predicting in-hospital mortality. The AUROC of AEC was plotted and found to be 0.881, which was better than other parameters for predicting in-hospital mortality. The cutoff of AEC by Youden’s index was 110 cells/cumm (sensitivity 91.3%, specificity 89%, positive predictive value 87.5%, and negative predictive value 93%) to predict in-hospital mortality. The AUROC of MELD was 0.78 with a cutoff of > 24 (sensitivity 89%, specificity 74.6%, positive predictive value 73%, and negative predictive value 89%) to predict the mortality. The odds ratio for predicting mortality was highest for absolute eosinophil count (92.75) followed by MELD (24.57), total count (20.475), CTP (10), and the presence of SIRS (9.08). Conclusion In critically ill cirrhosis patients with sepsis, AEC < 110 cells/cumm can predict in-hospital mortality.

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Role of eosinopenia in predicting mortality and morbidity in patients with Chronic Obstructive Pulmonary Disease (COPD)

Cited by 2 publications

References 0 publications

(BAP65) Score versus (DECAF) Score in Assessment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

(BAP65) Score versus (DECAF) Score in Assessment of Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Eosinophil count: a predictor of in-hospital mortality in a cohort of cirrhosis patients with sepsis

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