Role of Epidermal Growth Factor Receptor Expression on Patient Survival in Pancreatic Cancer: A Meta-Analysis

Luo, Guopei; Jiang, Long; Qiu, Lixin; Liu, Chen; Xu, Jin; Lei, Yu

doi:10.1159/000334465

Cited by 22 publications

(15 citation statements)

References 30 publications

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“…In PDA samples the EGFR expression was found to be related with lymph node metastasis and with vascular invasion. These results are in accordance with previous studies in which EGFR activation results in the transcription of genes involved in cell growth and proliferation and, consequently, its expression is associated with poor prognosis and increased invasiveness …”

Section: Discussionsupporting

confidence: 93%

“…EGFR is frequently overexpressed in tumors, including pancreatic cancer, and its activation leads to the transcription of genes involved in cell growth and proliferation. EGFR expression is also associated with poor prognosis and increased invasiveness in PDA . In addition, AQP3 and AQP5 have been implicated in epithelial mesenchymal transition (EMT), a process in invasive tumors that contributes to invasion and metastasis and by which cells lose their epithelial characteristics, such as cell‐cell adhesion and lack of motility, and acquire migratory mesenchymal properties.…”

Section: Introductionmentioning

confidence: 99%

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Differential expression of aquaporin‐3 and aquaporin‐5 in pancreatic ductal adenocarcinoma

Direito

Paulino

Vigia

et al. 2017

Journal of Surgical Oncology

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 99%

Differential expression of aquaporin‐3 and aquaporin‐5 in pancreatic ductal adenocarcinoma

Direito

Paulino

Vigia

et al. 2017

Journal of Surgical Oncology

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“…Genetic ablation or pharmacological inhibition of EGFR or ADAM17 effectively eliminates KRAS-driven tumorigenesis (17,387), and EGFR TKIs erlotinib and gefitinib inhibit pancreatic tumor growth in mouse models (136,367). EGFR expression levels are inversely related to prognosis in patients with pancreatic cancers (321,561). Treatment with erlotinib in combination with gemcitabine in patients with locally advanced/metastatic chemonaive pancreatic cancer patients can produce a small but statistically significant increase in overall survival (490).…”

Section: Egfr and Pancreatic Tumorigenesismentioning

confidence: 99%

Expression and Function of the Epidermal Growth Factor Receptor in Physiology and Disease

Chen

Zeng

Forrester

et al. 2016

Physiological Reviews

222

156

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The epidermal growth factor receptor (EGFR) is the prototypical member of a family of membrane-associated intrinsic tyrosine kinase receptors, the ErbB family. EGFR is activated by multiple ligands, including EGF, transforming growth factor (TGF)-α, HB-EGF, betacellulin, amphiregulin, epiregulin, and epigen. EGFR is expressed in multiple organs and plays important roles in proliferation, survival, and differentiation in both development and normal physiology, as well as in pathophysiological conditions. In addition, EGFR transactivation underlies some important biologic consequences in response to many G protein-coupled receptor (GPCR) agonists. Aberrant EGFR activation is a significant factor in development and progression of multiple cancers, which has led to development of mechanism-based therapies with specific receptor antibodies and tyrosine kinase inhibitors. This review highlights the current knowledge about mechanisms and roles of EGFR in physiology and disease.

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“…The frequency of HER1 expression in pancreatic cancer has been reported as 30.4% [23] and 45.1% [25] in two previous studies. In our study HER1 expression was observed in 41.4% of patients.…”

Section: Discussionmentioning

confidence: 99%

“…HER1 overexpression has previously been associated with decreased survival [23, 24], and the cumulative 1-, 3- and 5-year survival rates were 48, 20 and 18%, respectively [24]. A previous meta-analysis has shown that three trials reported a survival disadvantage for patients with HER1 expression, while other five trials reported no significant difference, however, the combined hazard ratio was 1.225 ( P = 0.035) [25]. Another meta-analysis drew the opposite conclusion that HER1 was not a significant prognostic factor in resected pancreatic cancer (HR = 1.35, 95% CI 0.80–2.27, P > 0.05) [26].…”

Section: Discussionmentioning

confidence: 99%

The prognostic significance of human epidermal growth factor receptor family protein expression in operable pancreatic cancer

Zhang

et al. 2016

BMC Cancer

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BackgroundPrognostic factors aid in the stratification and treatment of cancer. This study evaluated the prognostic significance of human epidermal growth factor receptor (HER) family members (HER1–4) expression in patients with operable pancreatic cancer.MethodsThe expression of individual HER proteins in patient tissue specimens was detected by immunohistochemistry staining. Patient follow-up time was between 1.0 and 78.1 months.ResultsPositive expression of HER1, HER2, HER3 and HER4 was detected in 41.4, 60.0, 24.3 and 65.7% of cases, respectively. Kaplan–Meier analysis revealed that HER3 positive expression was associated with decreased median survival time (12.0 vs. 25.6 months for HER3 positive and negative groups, respectively; P = 0.013). Cox’s regression confirmed that positive HER3 expression was an independent predictor of poor survival (RR = 3.684, P = 0.001). In contrast, HER4 negative patients had a significantly decreased median survival time when compared with HER4 positive patients (11.4 vs. 25.6 months, respectively; P = 0.027). However, HER4 was not an independent predictor of survival. No significant association between HER1 or HER2 expression and survival was observed (P = 0.626 & P = 0.859, respectively).ConclusionsHER3 is an independent prognostic marker for patients with operable pancreatic cancer. HER4 may also be of potential prognostic value in this disease and deserves further attention.

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Role of Epidermal Growth Factor Receptor Expression on Patient Survival in Pancreatic Cancer: A Meta-Analysis

Cited by 22 publications

References 30 publications

Differential expression of aquaporin‐3 and aquaporin‐5 in pancreatic ductal adenocarcinoma

Differential expression of aquaporin‐3 and aquaporin‐5 in pancreatic ductal adenocarcinoma

Expression and Function of the Epidermal Growth Factor Receptor in Physiology and Disease

The prognostic significance of human epidermal growth factor receptor family protein expression in operable pancreatic cancer

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