Role of epigenetic modifications in stem cell regulatory regions (Oct4, Sox2 and Nanog) and cancer

Abstract

Epigenetics is the study which involves the modifications in gene expression

Bovine Peripheral Blood-Derived Mesenchymal Stem Cells (PB-MSCs) and Spermatogonial Stem Cells (SSCs) Display Contrasting Expression Patterns of Pluripotency and Germ Cell Markers under the Effect of Sertoli Cell Conditioned Medium

“…NANOG , OCT4 , and SOX2 are transcription factors that regulate common target genes that promote pluripotency and self-renewal, while inhibiting the differentiation processes [ 54 ]. NANOG expression is promoted by OCT4 and SOX2 expression [ 54 , 55 ], and together, these three factors regulate a network of genes involved in control of factors associated with chromatin remodeling, cell cycle, and signal suppression [ 56 ]. These genes are expressed in both pluripotent GCs and early GCs [ 56 , 57 ].…”

“…NANOG expression is promoted by OCT4 and SOX2 expression [ 54 , 55 ], and together, these three factors regulate a network of genes involved in control of factors associated with chromatin remodeling, cell cycle, and signal suppression [ 56 ]. These genes are expressed in both pluripotent GCs and early GCs [ 56 , 57 ]. Consequently, its high expression indicates a state of undifferentiation in pluripotent cells, and its low expression would occur during cell differentiation [ 58 , 59 ].…”