Role of epigenetics in transformation of inflammation into colorectal cancer

Yang, Zhenhua; Dang, Yanqi; Ji, Guang

doi:10.3748/wjg.v25.i23.2863

Cited by 62 publications

(46 citation statements)

References 133 publications

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“…The promoter region of the RNF180 gene is composed of abundant CpG islands, which are primarily located in -202/+372 promoter region of RNF180 (17). DNA methylation regulates transcription and acts on CpG islands (18)(19)(20). However, unmethylated DNA results in either loss or low levels of gene expression.…”

Section: Discussionmentioning

confidence: 99%

Ring finger protein 180 is associated with biological behavior and prognosis in patients with non‑small cell lung cancer

Liu

Yang

et al. 2020

Oncol Lett

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There are few studies on the role of ring finger protein (RNF)180 in non-small cell lung cancer (NSCLC). The present study investigated the expression of RNF180 in NSCLC and its associations with the clinical factors and prognosis of NSCLC. The mRNA and protein expression levels of RNF180 were detected via reverse transcription-quantitative PCR and western blotting. Methylation-specific PCR (MSP) analysis was utilized to detect the methylation of RNF180. RNF180 expression levels were analyzed via immunohistochemistry. The protein and mRNA expression levels of RNF180 were lower in NSCLC cell lines compared with in the non-tumor cell line. Immunohistochemistry revealed that 64 patients that were negative for RNF180, while MSP detection analysis demonstrated that 60 patients exhibited RNF180 promoter methylation. The methylation status of RNF180 was significantly associated with RNF180 expression level. Among all factors evaluated, logistic regression analysis indicated that only T stage was significantly associated with RNF180 expression. Cox multivariate analysis demonstrated that RNF180 expression was an independent predictor of overall survival in patients with NSCLC. Methylation in the promoter of RNF180 was shown to reduce its expression levels. In summary, low RNF180 expression levels were associated with poor biological behaviors, thus RNF180 expression level may be used as a clinical marker to predict the prognosis of patients with NSCLC. Materials and methods Cell culture. NSCLC cell lines (A549 and HCC827) and a non-tumor cell line (MRC-5) were obtained from The Cell Bank of Type Culture Collection of Chinese Academy of Sciences. Cells were cultured in RPMI-1640 medium (Gibco; Thermo Fisher Scientific, Inc.) supplemented with 10% FBS (HyClone; Cytiva) and 100 U/ml penicillin-streptomycin (HyClone; Cytiva) at 37˚C under a humidified atmosphere of 5% CO 2 .

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Section: Discussionmentioning

confidence: 99%

Ring finger protein 180 is associated with biological behavior and prognosis in patients with non‑small cell lung cancer

Liu

Yang

et al. 2020

Oncol Lett

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“…Epigenetic dysregulation plays a role in all stages of cancer transformation. It can be induced by genetic changes, first mutations in genes encoding epigenetic regulators, or by tissue inflammation affecting cell signaling, resulting in altered chromatin organization [48].…”

Section: Epigenetic Mechanisms In Cancer Transformation and Agingmentioning

confidence: 99%

Nutrition in Cancer Therapy in the Elderly—An Epigenetic Connection?

et al. 2020

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The continuous increase in life expectancy results in a steady increase of cancer risk, which consequently increases the population of older adults with cancer. Older adults have their age-related nutritional needs and often suffer from comorbidities that may affect cancer therapy. They frequently are malnourished and present advanced-stage cancer. Therefore, this group of patients requires a special multidisciplinary approach to optimize their therapy and increase quality of life impaired by aging, cancer, and the side effects of therapy. Evaluation strategies, taking advantage of comprehensive geriatric assessment tools, including the comprehensive geriatric assessment (CGA), can help individualize treatment. As epigenetics, an emerging element of the regulation of gene expression, is involved in both aging and cancer and the epigenetic profile can be modulated by the diet, it seems to be a candidate to assist with planning a nutritional intervention in elderly populations with cancer. In this review, we present problems associated with the diet and nutrition in the elderly undergoing active cancer therapy and provide some information on epigenetic aspects of aging and cancer transformation. Nutritional interventions modulating the epigenetic profile, including caloric restriction and basal diet with modifications (elimination diet, supplementary diet) are discussed as the ways to improve the efficacy of cancer therapy and maintain the quality of life of older adults with cancer.

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“…Because the causes of CRC are so diverse, multidrug combinations known as´cocktail therapy' will promote more systematic treatment of the disease. Finally, the concept of epigenetics has been widely applied in the occurrence and development of CRC, and investigating these changes will help us explore new treatment options and improve the early diagnosis and treatment of CRC [172].…”

Section: Resultsmentioning

confidence: 99%

Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathways

et al. 2020

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Colorectal cancer (CRC) is the third most common malignancy and one of the leading causes of cancer-related death among men worldwide. CRC is a multifactor digestive pathology, which is a huge problem faced not only by clinicians but also by researchers. Importantly, a unique feature of CRC is the dysregulation of molecular signaling pathways. To date, a series of reviews have indicated that different signaling pathways are disordered and have potential as therapeutic targets in CRC. Nevertheless, an overview of the function and interaction of multiple signaling pathways in CRC is needed. Therefore, we summarized the pathways, biological functions and important interactions involved in CRC. First, we investigated the involvement of signaling pathways, including Wnt, PI3K/Akt, Hedgehog, ErbB, RHOA, Notch, BMP, Hippo, AMPK, NF-κB, MAPK and JNK. Subsequently, we discussed the biological function of these pathways in pathophysiological aspects of CRC, such as proliferation, apoptosis and metastasis. Finally, we summarized important interactions among these pathways in CRC. We believe that the interaction of these pathways could provide new strategies for the treatment of CRC.

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Role of epigenetics in transformation of inflammation into colorectal cancer

Cited by 62 publications

References 133 publications

Ring finger protein 180 is associated with biological behavior and prognosis in patients with non‑small cell lung cancer

Ring finger protein 180 is associated with biological behavior and prognosis in patients with non‑small cell lung cancer

Nutrition in Cancer Therapy in the Elderly—An Epigenetic Connection?

Colorectal cancer (CRC) as a multifactorial disease and its causal correlations with multiple signaling pathways

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