Role of Epstein-Barr virus infection in SLE: gene-environment interactions at the molecular level

Pisetsky, David S.

doi:10.1136/annrheumdis-2018-213783

Cited by 15 publications

(8 citation statements)

References 8 publications

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“…44 Additionally, studies have demonstrated evidence of molecular mimicry between EBV proteins and nuclear antigens, and the EBV nuclear antigen 2 D 1 1 3 X Xprotein can bind to several SLE risk alleles, suggesting important mechanisms by which EBV can trigger autoimmunity. [44][45][46] The role of other viruses such as Cytomegalovirus D 1 1 4 X Xin the pathogenesis of SLE is less clear.…”

Section: Relationship Between Sle and Risk Of Viral Infectionsmentioning

confidence: 99%

COVID-19 in patients with systemic lupus erythematosus: lessons learned from the inflammatory disease

Fernández-Ruiz

Paredes

Niewold

2021

Translational Research

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As the world navigates the Coronavirus disease 2019 (COVID-19) pandemic, there is a growing need to assess its impact in patients with autoimmune rheumatic diseases, such as systemic lupus erythematosus (SLE). Patients with SLE are a unique population when considering the risk of contracting COVID-19 and infection outcomes. The use of systemic glucocorticoids and immunosuppressants, and underlying organ damage from SLE are potential susceptibility factors. Most patients with SLE have evidence of high type I IFN activity, which may theoretically act as an antiviral line of defense or contribute to the development of a deleterious hyperinflammatory response in COVID-19. Other immunopathogenic mechanisms of SLE may overlap with those described in COVID-19, and thus studies in SLE could provide some insight into immune responses occurring in severe cases of the viral infection. We reviewed the literature to date on COVID-19 in patients with SLE and provide an in-depth review of current research in the area, including immune pathway activation, epidemiology, clinical features, outcomes, and the psychosocial impact of the pandemic in those with autoimmune disease.

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Section: Relationship Between Sle and Risk Of Viral Infectionsmentioning

confidence: 99%

COVID-19 in patients with systemic lupus erythematosus: lessons learned from the inflammatory disease

Fernández-Ruiz

Paredes

Niewold

2021

Translational Research

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“…The numerous activated CD4 + T lymphocytes segregate large amounts of cytokines, generating the chronic inflammatory response characteristic of SLE . In this sense recently, Pisetsky analyzed the mechanisms by which EBV can trigger this disease.…”

Section: Introductionmentioning

confidence: 99%

Infectious processes and systemic lupus erythematosus

et al. 2019

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Systemic lupus erythematosus (SLE) is an autoimmune chronic inflammatory disease of unknown etiology, although genetic and environmental factors appear to contribute to its pathogenesis. Specifically, infectious processes are associated with SLE onset and exacerbation. However, we are far from a complete understanding of the interactions between infectious agents and the host, explaining the interest in gathering updated scientific information on this topic. According to the literature, the pathogens most frequently associated with SLE are viruses, notably human endogenous retroviruses, Epstein-Barr virus, parvovirus B19, cytomegalovirus and human immunodeficiency virus type 1, alongside certain bacterial components that can also trigger activation of the immune system. The mechanisms underlying autoreactivity remain unclear but various explanations have been proposed, including immunological changes responsible for infectious processes or molecular mimicry between host structures and those of infectious agents.

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“…In addition, patients with SLE are reported to have increased titers of anti-EBV antibodies, increased frequencies of EBV-infected peripheral B cells, high viral loads in the peripheral blood mononuclear cells, and increased frequencies of EBV-DNA elevation in serum ( 2 , 11 ). The proposed mechanism by which EBV promotes SLE pathogenesis includes defective T cell responses to EBV infection in patients with SLE, molecular mimicry between the EBNA1 protein and the SmB and Ro60 proteins, and associations between the EBNA2 protein and SLE risk alleles ( 2 , 10 , 12 ). Considering the close association of EBV and SLE, it seems reasonable to assume that EBV-LPD can present with SLE-like manifestations.…”

Section: Discussionmentioning

confidence: 99%

Age-related Epstein-Barr Virus-associated Lymphoproliferative Disorder Masquerading as Systemic Lupus Erythematosus

et al. 2021

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Age-related Epstein-Barr virus (EBV)-positive B-cell lymphoproliferative disorder (LPD) occurs in elderly patients without immunodeficiency. An 81-year-old woman without any known immunodeficiency was examined for fever, rash, arthritis, thrombocytopenia, pleural and pericardial effusions, lymphadenopathy, and positive autoantibodies, which satisfied the classification criteria for systemic lupus erythematosus (SLE). However, a lymph node biopsy revealed EBV-LPD, and she was diagnosed with age-related EBV-LPD. In young individuals, EBV infection is a major differential diagnosis of SLE, but to our knowledge, this is the first reported case of age-related EBV-LPD mimicking SLE. We should therefore consider EBV-related disorders in the differential diagnosis of SLE even in elderly individuals.

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Role of Epstein-Barr virus infection in SLE: gene-environment interactions at the molecular level

Cited by 15 publications

References 8 publications

COVID-19 in patients with systemic lupus erythematosus: lessons learned from the inflammatory disease

COVID-19 in patients with systemic lupus erythematosus: lessons learned from the inflammatory disease

Infectious processes and systemic lupus erythematosus

Age-related Epstein-Barr Virus-associated Lymphoproliferative Disorder Masquerading as Systemic Lupus Erythematosus

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