Role of ERK signaling in activity-dependent modifications of histone proteins

Ciccarelli, Alessandro; Giustetto, Maurizio

doi:10.1016/j.neuropharm.2014.01.039

Cited by 62 publications

(52 citation statements)

References 135 publications

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“…The MAPK/ERK pathway is involved in the regulation of a variety of growth and differentiation pathways through several phosphorylation cascades. The signalling cascade is activated by a number of receptors, including receptor tyrosine kinase, integrins and ion channels, which then transduce the signal to adaptors that eventually activate Raf, MEK1/2 and ERK [6,18]. Previous data have shown that the ERK signalling pathway is very important in Schwann cells after PNI [17,18,23].…”

Section: Discussionmentioning

confidence: 99%

Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury

Song

Zhu

et al. 2015

Purinergic Signalling

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Peripheral nerve injury (PNI) is a common disease, which results in a partial or total loss of motor, sensory and autonomic functions, leading to a decrease in quality of life. Schwann cells play a vital role in maintaining the peripheral nervous system and in injury and repair. Using immunohistochemistry, Western blot, calcium assay and bromodeoxyuridine (BrdU) proliferation assay, the present study clearly demonstrated that P2X7 receptors (R) were expressed in myelinating and non-myelinating Schwann cells in longitudinal sections of sciatic nerves. After sciatic nerve injury (SNI), P2X7R expression in Schwann cells of injured sciatic nerves was significantly up-regulated during the early days of SNI. Double immunofluorescence of proliferating cell nuclear antigen (PCNA) and P2X7R implied that P2X7R may be involved in proliferation of Schwann cells. Further experiments on primary cultures of Schwann cells showed that P2X7R are functionally expressed in Schwann cells of rat sciatic nerves; ATP via P2X7R can promote Schwann cell proliferation, possibly via the MAPK/ERK intracellular signalling pathway. Other possible roles of P2X7R on Schwann cells are discussed.

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Section: Discussionmentioning

confidence: 99%

Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury

Song

Zhu

et al. 2015

Purinergic Signalling

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“…These modifications occur primarily within the histone amino-terminal tails protruding from the surface of the nucleosome as well as on the globular core region, and have been shown to influence both the accessibility of genomic regions and the binding of trans-acting factors to the DNA (27). Changes in acetylation and phosphorylation in response to drug exposure are often transient and appear to be associated with the quick activation of genes rather than the maintenance of an altered transcription state (28). However, histone lysine methylation is known to maintain stable gene expression alterations, and it is also the nucleosomal modification that has been associated with the long-term effects of marijuana and different cannabinoids in neurons and other cell types (29–32).…”

Section: Epigenetic Mechanismsmentioning

confidence: 99%

Epigenetic Effects of Cannabis Exposure

Szutorisz

Hurd

2016

Biological Psychiatry

186

103

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The past decade has witnessed a number of societal and political changes that have raised critical questions about the long-term impact of marijuana (Cannabis sativa) that are especially important given the prevalence of its abuse and that potential long-term effects still largely lack scientific data. Disturbances of the epigenome have generally been hypothesized as the molecular machinery underlying the persistent, often tissue-specific transcriptional and behavioral effects of cannabinoids that have been observed within one's lifetime and even into the subsequent generation. Here, we provide an overview of the current published scientific literature that examined epigenetic effects of cannabinoids. Though mechanistic insights about the epigenome remain sparse, accumulating data in humans and animal models have begun to reveal aberrant epigenetic modifications in brain and the periphery linked to cannabis exposure. Expansion of such knowledge and causal molecular relationships could help provide novel targets for future therapeutic interventions.

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“…40,41 The transcription factor c-Fos, encoded by immediate early gene CFOS, is an important downstream ERK1/2-signaling component for the formation of long-term modification of synaptic response. It has been confirmed that p-ERK1/2 can mediate the upregulation of c-Fos expression, which enables neurons to transcribe and translate the corresponding proteins affecting memory function.…”

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confidence: 99%

Impairments of spatial learning and memory following intrahippocampal injection in rats of 3-mercaptopropionic acid-modified CdTe quantum dots and molecular mechanisms

Wu¹,

He²,

Ang³

et al. 2016

IJN

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With the rapid development of nanotechnology, quantum dots (QDs) as advanced nanotechnology products have been widely used in neuroscience, including basic neurological studies and diagnosis or therapy for neurological disorders, due to their superior optical properties. In recent years, there has been intense concern regarding the toxicity of QDs, with a growing number of studies. However, knowledge of neurotoxic consequences of QDs applied in living organisms is lagging behind their development, even if several studies have attempted to evaluate the toxicity of QDs on neural cells. The aim of this study was to evaluate the adverse effects of intrahippocampal injection in rats of 3-mercaptopropionic acid (MPA)-modified CdTe QDs and underlying mechanisms. First of all, we observed impairments in learning efficiency and spatial memory in the MPA-modified CdTe QD-treated rats by using open-field and Y-maze tests, which could be attributed to pathological changes and disruption of ultrastructure of neurons and synapses in the hippocampus. In order to find the mechanisms causing these effects, transcriptome sequencing (RNA-seq), an advanced technology, was used to gain the potentially molecular targets of MPA-modified CdTe QDs. According to ample data from RNA-seq, we chose the signaling pathways of PI3K–Akt and MPAK–ERK to do a thorough investigation, because they play important roles in synaptic plasticity, long-term potentiation, and spatial memory. The data demonstrated that phosphorylated Akt (p-Akt), p-ERK1/2, and c-FOS signal transductions in the hippocampus of rats were involved in the mechanism underlying spatial learning and memory impairments caused by 3.5 nm MPA-modified CdTe QDs.

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Role of ERK signaling in activity-dependent modifications of histone proteins

Cited by 62 publications

References 135 publications

Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury

Up-regulation of P2X7 receptors mediating proliferation of Schwann cells after sciatic nerve injury

Epigenetic Effects of Cannabis Exposure

Impairments of spatial learning and memory following intrahippocampal injection in rats of 3-mercaptopropionic acid-modified CdTe quantum dots and molecular mechanisms

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