Role of Ero1α in cognitive impairment induced by chronic hypoxia

Zhang, Nan; Shentu, Yangping; Zhu, Meifang; Wang, Hui; Yin, Xianghong; Du, Congkuo; Xue, Fu‐Shan; Fan, Junming; Gong, Yanling; Fan, Xiaofang

doi:10.1016/j.brainres.2022.148117

Cited by 2 publications

(6 citation statements)

References 37 publications

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“…Indeed, 84% of the 'low dose' hypoxia studies (k = 9 in humans; k = 11 in animals) observed beneficial effects on measures of global cognition, memory, attention, motor function, and neuroplasticity markers (i.e., increased levels of neurotrophins, EPO, neurogenesis, etc.) [9,18,19,[22][23][24]26,[42][43][44][45]53,65,69,73]. In contrast, only 18% of the studies with higher doses of hypoxia exposure (k = 1 in hu-mans; k = 37 in animals) showed beneficial effects, while 79% reported negative effects on cognition, brain structure, oxidative stress, inflammation, and Alzheimer's disease markers [20,27,28,31,32,35,36,[38][39][40][41]47,49,50,54,57,59,[61][62][63][64]66,[69][70][71][72].…”

Section: Discussionmentioning

confidence: 99%

“…Of the 48 included animal studies, 28 (58.5%) observed adverse effects of hypoxia exposure [27][28][29]31,32,35,36,[38][39][40][41]46,47,49,50,57,59,[61][62][63][64]66,67,[69][70][71][72], while 18 studies (37.5%) reported beneficial effects [26,33,34,37,[42][43][44][45]48,51,53,55,56,58,60,65,68,73] and two studies (4%) found either no change in outcomes or mixed findings in both directions after hypoxia treatment [30,52].…”

Section: Effects Of Moderate Hypoxia In Animal Studiesmentioning

confidence: 99%

“…Thirty-three studies examined hypoxia-related changes in hippocampal-dependent learning and memory performance, mostly assessed with the Morris water maze paradigm (27 of 33 studies) [30][31][32][34][35][36][38][39][40][41][42]44,45,50,51,[54][55][56][57][59][60][61][62][63][64][65]72]. Of these, 21 studies reported impaired learning and memory following various protocols with higher doses of hypoxia, including normobaric intermittent hypoxia (mainly 10% O 2 ) chronically administered for +10 h daily over 2-4 weeks, or hypobaric continuous hypoxia of 11-13% O 2 chronically administered over 4-12 weeks [31,32,35,36,[38][39][40][41]50,54,57,59,[61][62][63][64]66,67,69,…”

Section: Cognition and Neuropsychiatric Behaviormentioning

confidence: 99%

“…Twenty-three studies examined hypoxia-related changes in neuronal morphology in rodents (see Table 2). Out of these, 13 studies investigated neurodegeneration, which involved apoptosis in the hippocampus [30,35,36,40,61,62,69,71,73], frontal and temporal cortex [43,70], and the basal forebrain [57]. Eight studies reported increased neuroapoptosis following higher hypoxic doses, involving 8+ hours of daily normobaric or hypobaric hypoxia (intensities between 10 and 13% O 2 ) chronically for 2-8 weeks when compared to normoxia controls [35,36,40,57,62,69,71,72].…”

Section: Neuronal Morphological Changesmentioning

confidence: 99%

“…Out of these, 13 studies investigated neurodegeneration, which involved apoptosis in the hippocampus [30,35,36,40,61,62,69,71,73], frontal and temporal cortex [43,70], and the basal forebrain [57]. Eight studies reported increased neuroapoptosis following higher hypoxic doses, involving 8+ hours of daily normobaric or hypobaric hypoxia (intensities between 10 and 13% O 2 ) chronically for 2-8 weeks when compared to normoxia controls [35,36,40,57,62,69,71,72]. Two studies found no apoptosis, one after normobaric intermittent 10% O 2 exposure chronically for one month [30], and one after hypobaric continuous 11-14% O 2 repeated for four hours daily for two weeks [73].…”

Section: Neuronal Morphological Changesmentioning

confidence: 99%

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Neuroprotective Effects of Moderate Hypoxia: A Systematic Review

Damgaard,

Mariegaard,

Lindhardsen

et al. 2023

Brain Sciences

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Emerging evidence highlights moderate hypoxia as a candidate treatment for brain disorders. This systematic review examines findings and the methodological quality of studies investigating hypoxia (10–16% O2) for ≥14 days in humans, as well as the neurobiological mechanisms triggered by hypoxia in animals, and suggests optimal treatment protocols to guide future studies. We followed the preferred reporting items for systematic reviews and meta-analysis (PRISMA) 2020. Searches were performed on PubMed/MEDLINE, PsycInfo, EMBASE, and the Cochrane Library, in May–September 2023. Two authors independently reviewed the human studies with the following tools: (1) revised Cochrane collaboration’s risk of bias for randomized trials 2.0; (2) the risk of bias in nonrandomized studies of interventions. We identified 58 eligible studies (k = 8 human studies with N = 274 individuals; k = 48 animal studies) reporting the effects of hypoxia on cognition, motor function, neuroimaging, neuronal/synaptic morphology, inflammation, oxidative stress, erythropoietin, neurotrophins, and Alzheimer’s disease markers. A total of 75% of human studies indicated cognitive and/or neurological benefits, although all studies were evaluated ashigh risk of bias due to a lack of randomization and assessor blinding. Low-dose intermittent or continuous hypoxia repeated for 30–240 min sessions, preferably in combination with motor-cognitive training, produced beneficial effects, and high-dose hypoxia with longer (≥6 h) durations and chronic exposure produced more adverse effects. Larger and methodologically stronger translational studies are warranted.

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