Role of estrogens in androgen-induced spontaneous activity in male rats.

Roy, Edward J.; Wade, George N.

doi:10.1037/h0077436

Cited by 84 publications

(65 citation statements)

References 28 publications

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“…It was found in this study that estrogen greatly potentiated running wheel activity in mice, as previously reported in rats (2)(3)(4)(5). The present study demonstrates for the first time a differential dependence on the ER␣ vs. the ER␤ gene in the estrogenic regulation of running wheel activity.…”

Section: Roles Of Er␣ and Er␤ In Estrogenic Regulation Of Running Whesupporting

confidence: 82%

“…Gonadally intact female rats show the highest activity during proestrus, when plasma levels of estrogen are elevated (1). In gonadectomized female and male rats, it has been shown that estrogen treatment increases running wheel activity (2)(3)(4)(5), although estrogen failed to do so in ferrets of both sexes (6). A number of lesion (7), electrophysiological (8), and site-specific steroid implant studies (9) revealed that the medial preoptic area (mPOA) is the primary brain site responsible for this behavioral effect of estrogen, although the anterior hypothalamic area just posterior to mPOA may also be involved.…”

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confidence: 99%

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Estrogen Increases Locomotor Activity in Mice through Estrogen Receptor α: Specificity for the Type of Activity

et al. 2003

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Estrogens are known to increase running wheel activity of rodents primarily by acting on the medial preoptic area (mPOA). The mechanisms of this estrogenic regulation of running wheel activity are not completely understood. In particular, little is known about the separate roles of two types of estrogen receptors, ERalpha and ERbeta, both of which are expressed in mPOA neurons. In the present study the effects of continuous estrogen treatment on running wheel activity were examined in male and female mice specifically lacking either the ERalpha (alphaERKO) or the ERbeta (betaERKO) gene. Mice were gonadectomized and 1 wk later implanted with either a low dose (16 ng/d) or a high dose (160 ng/d) of estradiol benzoate (EB) or with a placebo control pellet. Home cage running wheel activity was recorded for 9 d starting 10 d after EB implants. The same mice were also tested for open field activity before and after EB implants. In both female and male alphaERKO mice, running wheel activity was not different from that in corresponding wild-type (alphaWT) mice in placebo control groups. In both females and males it was increased by EB only in alphaWT, not alphaERKO, mice. In betaERKO mice, on the other hand, both doses of EB equally increased running wheel activity in both sexes just as they did in betaWT mice. Absolute numbers of daily revolutions of EB-treated groups, however, were significantly lower in betaERKO females compared with betaWT females. Before EB treatment, gonadectomized alphaERKO female were significantly less active than alphaWT mice in open field tests, whereas betaERKO females tended to be more active than betaWT mice. In male mice there were no effect of ERalpha or ERbeta gene knockout on open field activity. Unlike its effect on running wheel activity, EB treatment induced only a small increase in open field activity in female, but not male, mice. These findings indicate that 1) in both sexes estrogenic regulation of running wheel activity is primarily mediated through the ERalpha, not the ERbeta; and 2) hormone/genotype effects are specific to the type of locomotor activity (i.e. home cage running wheel activity and open field activity) measured.

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Section: Roles Of Er␣ and Er␤ In Estrogenic Regulation Of Running Whesupporting

confidence: 82%

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confidence: 99%

Estrogen Increases Locomotor Activity in Mice through Estrogen Receptor α: Specificity for the Type of Activity

et al. 2003

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“…In rats, conversion of testosterone to estradiol may be important for the activity-stimulating effects of testosterone (Roy andWade, 1975). Estradiol is nearly 100 times as effective as testosterone at increasing activity, while dihydrotesosterone (a non-aromatizable androgen) has no effect on wheel-running activity of rats (Roy and Wade, 1975). Taken together, these findings suggest that the conversion of testosterone to estrogen, by aromatase, may be important for the effects of testosterone on circadian rhythms.…”

Section: Endocrine Influences On the Circadian Systemmentioning

confidence: 84%

The regulation of neuroendocrine function: Timing is everything

Kriegsfeld

Silver

2006

Hormones and Behavior

131

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Hormone secretion is highly organized temporally, achieving optimal biological functioning and health. The master clock located in the suprachiasmatic nucleus (SCN) of the hypothalamus coordinates the timing of circadian rhythms, including daily control of hormone secretion. In the brain, the SCN drives hormone secretion. In some instances, SCN neurons make direct synaptic connections with neurosecretory neurons. In other instances, SCN signals set the phase of "clock genes" that regulate circadian function at the cellular level within neurosecretory cells. The protein products of these clock genes can also exert direct transcriptional control over neuroendocrine releasing factors. Clock genes and proteins are also expressed in peripheral endocrine organs providing additional modes of temporal control. Finally, the SCN signals endocrine glands via the autonomic nervous system, allowing for rapid regulation via multisynaptic pathways. Thus, the circadian system achieves temporal regulation of endocrine function by a combination of genetic, cellular, and neural regulatory mechanisms to ensure that each response occurs in its correct temporal niche. The availability of tools to assess the phase of molecular/cellular clocks and of powerful tract tracing methods to assess connections between "clock cells" and their targets provides an opportunity to examine circadian-controlled aspects of neurosecretion, in the search for general principles by which the endocrine system is organized. KeywordsCircadian; Diurnal; Endocrinel; Neurosecretion; Clock genes; Suprachiasmatic Circadian aspects of reproductionThe importance of circadian (about a day) timing in hormone production/secretion has been known since the 1950s when Everett and Sawyer determined that a stimulatory signal occurring during a narrow temporal window on the afternoon of proestrus is necessary for induction of ovulation later that night (Everett and Sawyer, 1950). Such close temporal organization is important for successful reproduction, as numerous hormone-dependent behavioral and physiological processes must be coordinated. If optimal temporal relationships are disrupted, pronounced deficits in fertility can result. For example, ovulation, behavioral estrus, fertilization, and pregnancy maintenance require a specific

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“…Data from several animal experiments clearly show that oestrogen deficiency in ovx rats may increase food intake (Gray and Wade, 1981;Pedersen et al, 2001) and decrease adipose tissue lipolysis (Darimont et al, 1997), spontaneous physical activity (Roy and Wade, 1975), and energy expenditure (Heine et al, 2000;Pedersen et al, 2001). Also, it has been shown that hypoestrogenemia in ovx rats causes central leptin insensitivity and increases hypothalamic neuropeptide Y levels and thereby contribute to excess fat accumulation (Ainslie et al, 2001).…”

Section: Menopause Hormonal Changes and Obesitymentioning

confidence: 99%

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

Rachoń

Teede

2010

Molecular and Cellular Endocrinology

136

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Insulin resistance (IR) is a consequence of obesity, and in women it is often inextricably linked with ovarian function leading to clinical reproductive manifestations such as early menarche onset, subfertility and polycystic ovary syndrome (PCOS). Likewise, the dramatic fall in oestrogen production after menopause may contribute to weight gain and changes in adipose tissue distribution.Overall, women who are obese, especially those with reproductive complications including PCOS, have been identified as specific high risk subgroups for further progression through to prediabetes, type 2 diabetes mellitus (T2DM) and potentially cardiovascular disease (CVD). This review focuses on the interrelationship between the ovarian function and obesity as well as its treatment strategies.

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Role of estrogens in androgen-induced spontaneous activity in male rats.

Cited by 84 publications

References 28 publications

Estrogen Increases Locomotor Activity in Mice through Estrogen Receptor α: Specificity for the Type of Activity

Estrogen Increases Locomotor Activity in Mice through Estrogen Receptor α: Specificity for the Type of Activity

The regulation of neuroendocrine function: Timing is everything

Ovarian function and obesity—Interrelationship, impact on women's reproductive lifespan and treatment options

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