Role of expression of p53 and Ki67 in the progression of Wilms tumor; correlation with survival

Abstract

It is with great pleasure that I write this editorial to welcome you to the IJCBR. This journal provides a platform for publication of original and reviews research articles, short communications, letter to editor, thesis abstract, conference report, and case studies. These types of publication are directed at the interface of the fields of cancer and biomedical research.The IJCBR relies on a distinguished expert of the Advisory and Editorial Board Members from the top international league covering in depth the related topics. They timely review all manuscripts and maintain highest standards of quality and scientific methodology and ethical concepts. Meanwhile, we take all possible means to keep the time of the publication process as short as possible.I take this chance to welcome your contributions to the IJCBR and have every expectation that it will soon become one of the most respected journals in both the fields of cancer and biomedical research.

High Expression of WT1 and Low Expression of p53 in Archived Blocks of Children with Wilms Tumor in South Western Uganda

“…This could also be attributed to the dominant mixed-type histology in our study compared to the blastemal component in these studies where p53 is mostly expressed. 15–17 The number of anaplastic tumors positive for p53 was lower than 76.2% reported in a study by Hill 27 which can be attributed to the large sample size of tumors known to have anaplasia recruited in this study. The difference can be explained by the fact that Hill et al recruited nephrectomy and trucut specimens that had not received preoperative chemotherapy as opposed to our study where most samples were after preoperative chemotherapy.…”

“…The expression of p53, however, was lower than 60.3%, and 56% from Egypt and 40% from Kenya. 15,17,21 A study by Salama recruited only nephrectomy specimens and would only include a specimen with at least 4 representative slides, as opposed to our study where even trucut biopsies were recruited which could have affected tumor The expression of WT1 is lower than 66.7% reported in the study done at Osaka University in Japan and 100% by Murphy. 21,25 The difference can be attributed to the different clone 6F-H2 anti-rabbit antibody used as opposed to our CAN-R9 IHC-56-2, while a study by Murphy recruited only blocks for 21 patients.…”

“…The expression of p53, however, was lower than 60.3%, and 56% from Egypt and 40% from Kenya. 15 , 17 , 21 A study by Salama recruited only nephrectomy specimens and would only include a specimen with at least 4 representative slides, as opposed to our study where even trucut biopsies were recruited which could have affected tumor topography. A study by Murphy received specimens from multiple sites which could have affected tissue processing.…”

“…The findings, however, are different from those reported elsewhere by Darwish 97.1% triphasic predominant in Egypt, 46.7% blastemal predominant in Nigeria, 49.2% blastemal predominant in Egypt, 81.9% triphasic predominant in Uganda, and 43% blastemal predominant in Uganda. [15][16][17][18][19] The difference can be explained by the variations in interpretations of the SIOP 2001 protocol 10 used in the classification of tumors that have received pre-operative chemotherapy, whereas the protocol does not recognize the term triphasic, some of the studies reported such a category that would otherwise be put under mixed type. The mixed type in this study is lower than 53.3% found in China among patients who had received chemotherapy.…”

The Antiproliferative Activity of Adiantum pedatum Extract and/or Piceatannol in Phenylhydrazine-Induced Colon Cancer in Male Albino Rats: The miR-145 Expression of the PI-3K/Akt/p53 and Oct4/Sox2/Nanog Pathways

“…For immunohistochemical studies, in the present study, PHZ showed high positivity for ki67 and p53 in colon cancer tissue. According to Darwish et al [ 116 ]’s results, high immunohistochemical nuclear positivities for ki67 and p53 in a Wilms tumor were shown. According to Nussrat, et al [ 117 ], the high-grade dysplasia of colorectal cancer showed significant positive immunohistochemical markers of Ki-67 and P53.…”