Role of extracellular vesicles in autoimmune diseases

Turpin, Delphine; Truchetet, Marie-Élise; Faustin, Benjamin; Augusto, Jean-François; Contin‐Bordes, Cécile; Brisson, Alain; Blanco, Patrick; Duffau, Pierre

doi:10.1016/j.autrev.2015.11.004

Cited by 121 publications

(97 citation statements)

References 129 publications

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“…Circulating EVs are thought to be released by platelets, erythrocytes and endothelial cells 6, 7 , but EVs from neurons, adipocytes and several other cell types can also be detected 8–10 . Given that a variety of cell types secrete EVs into the circulation, EVs have recently been identified as attractive biomarkers of tissue-specific diseases.…”

Section: Introductionmentioning

confidence: 99%

Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes

Eitan

Green²,

Bodogai

et al. 2017

Sci Rep

202

231

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Cells release lipid-bound extracellular vesicles (EVs; exosomes, microvesicles and apoptotic bodies) containing proteins, lipids and RNAs into the circulation. Vesicles mediate intercellular communication between both neighboring and distant cells. There is substantial interest in using EVs as biomarkers for age-related diseases including cancer, and neurodegenerative, metabolic and cardiovascular diseases. The majority of research focuses on identifying differences in EVs when comparing disease states and matched controls. Here, we analyzed circulating plasma EVs in a cross-sectional and longitudinal study in order to address age-related changes in community-dwelling individuals. We found that EV concentration decreases with advancing age. Furthermore, EVs from older individuals were more readily internalized by B cells and increased MHC-II expression on monocytes compared with EVs from younger individuals, indicating that the decreased concentration of EVs with age may be due in part to increased internalization. EVs activated both monocytes and B cells, and activation of B cells by LPS enhanced EV internalization. We also report a relative stability of EV concentration and protein amount in individual subjects over time. Our data provide important information towards establishing a profile of EVs with human age, which will further aid in the development of EV-based diagnostics for aging and age-related diseases.

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Section: Introductionmentioning

confidence: 99%

Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes

Eitan

Green²,

Bodogai

et al. 2017

Sci Rep

202

231

View full text Add to dashboard Cite

show abstract

“…For example, EVs are a source of self antigens, including MHC-displayed self-peptides, that could activate autoreactive T cells (9,67). In addition, the participation of EVs in immune complexes could stimulate autoimmunity.…”

Section: The Role Of Evs In Autoimmunitymentioning

confidence: 99%

“…Depending upon the context and vesicle type, EVs can stimulate or suppress the immune responses to infections with viruses and microbial pathogens as well as cancer. They also likely play a role in modulating inflammatory and autoimmune diseases, such as arthritis, diabetes, and lupus (9). Given their ability to modulate immune responses, EVs have tremendous potential as therapeutic agents for treating a variety of human diseases and disorders, including reducing inflammation, treating autoimmune diseases and cancer, and stimulating antipathogen immune responses.…”

Section: Introductionmentioning

confidence: 99%

Regulation of chronic inflammatory and immune processes by extracellular vesicles

Robbins

Dorronsoro

Booker

2016

Journal of Clinical Investigation

236

195

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“…The differentiation of memory B cells into plasmablasts/plasma cells results in abortive lytic replication of EBV and expression of the dUTPase, which may be released from infected cells through pyroptosis and/or in exosomes. Moreover, exosomes have been implicated in the pathogenesis of RA and SLE [119]. EBV-dUTPase stimulation of human dendritic cells and macrophages in the microenvironment would result in the increased expression and secretion of T H 1/T H 17 proinflammatory cytokines (TNF-α, IL-1β, IL-6, IL-8) as well as the anti-inflammatory cytokine IL-10 [7,25,27,29].…”

Section: Herpesviruses Dutpases and Human Diseasementioning

confidence: 99%

Herpesviruses dUTPases: A New Family of Pathogen-Associated Molecular Pattern (PAMP) Proteins with Implications for Human Disease

2016

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The human herpesviruses are ubiquitous viruses and have a prevalence of over 90% in the adult population. Following a primary infection they establish latency and can be reactivated over a person’s lifetime. While it is well accepted that human herpesviruses are implicated in numerous diseases ranging from dermatological and autoimmune disease to cancer, the role of lytic proteins in the pathophysiology of herpesvirus-associated diseases remains largely understudies. Only recently have we begun to appreciate the importance of lytic proteins produced during reactivation of the virus, in particular the deoxyuridine triphosphate nucleotidohydrolases (dUTPase), as key modulators of the host innate and adaptive immune responses. In this review, we provide evidence from animal and human studies of the Epstein–Barr virus as a prototype, supporting the notion that herpesviruses dUTPases are a family of proteins with unique immunoregulatory functions that can alter the inflammatory microenvironment and thus exacerbate the immune pathology of herpesvirus-related diseases including myalgic encephalomyelitis/chronic fatigue syndrome, autoimmune diseases, and cancer.

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Role of extracellular vesicles in autoimmune diseases

Cited by 121 publications

References 129 publications

Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes

Age-Related Changes in Plasma Extracellular Vesicle Characteristics and Internalization by Leukocytes

Regulation of chronic inflammatory and immune processes by extracellular vesicles

Herpesviruses dUTPases: A New Family of Pathogen-Associated Molecular Pattern (PAMP) Proteins with Implications for Human Disease

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