Role of FDG-PET in the Definition of Involved-Field Radiation Therapy and Management for Pediatric Hodgkin's Lymphoma

Robertson, Virginia Lang; Anderson, C.; Keller, Frank G.; Halkar, Raghuveer; Goodman, Michael; Marcus, Robert B.; Esiashvili, Natia

doi:10.1016/j.ijrobp.2010.02.002

Cited by 29 publications

(15 citation statements)

References 28 publications

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“…In two other studies with smaller number of patients, the same finding was observed. At Emory Clinic, 21 of the 30 (70%) patients had a change in RT field as a result of PET‐CT findings; a total of 32 sites were included and 15 excluded to the RT field 5. At Copenhagen University Hospital, only 10 of 30 (33.3%) patients had a change in the RT field; in 7 of the 10 patients, the RT field was larger as a result of PET‐CT 12.…”

Section: Discussionmentioning

confidence: 99%

“…The use of PET‐CT for initial staging of Hodgkin lymphoma can lead to a change in the treatment approach. When disease is found on PET‐CT not otherwise seen on conventional staging, the radiotherapy (RT) field may need to be adjusted to cover the new extent of tumor 4, 5. Likewise, areas of ambiguity on CT scan may be found to be non‐PET avid and therefore not included in the RT field.…”

Section: Introductionmentioning

confidence: 99%

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Impact of PET‐CT on involved field radiotherapy design for pediatric Hodgkin lymphoma

Paulino

Margolin

Dreyer

et al. 2011

Pediatric Blood & Cancer

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Impact of PET‐CT on involved field radiotherapy design for pediatric Hodgkin lymphoma

Paulino

Margolin

Dreyer

et al. 2011

Pediatric Blood & Cancer

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“…Some authors proposed methods based on image rigid coregistration and overlay (image fusion) and highlighted more favorable results if the [ 18 F]FDG-PET/CT scan is acquired on patients in treatment position. 13,16,24 However, in most cases, patients are scanned in different setup (position of the arms and/or neck) and/or using different scanners in different hospitals. In addition, weight loss and lymph node shrinkage occurring between the 2 imaging stages represent particularly challenging issues for CT-[…”

Section: Introductionmentioning

confidence: 99%

Radiotherapy of Hodgkin and Non-Hodgkin Lymphoma

Zaffino

Ciardo

Piperno

et al. 2015

Technol Cancer Res Treat

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Purpose: To improve the contouring of clinical target volume for the radiotherapy of neck Hodgkin/non-Hodgkin lymphoma by localizing the prechemotherapy gross target volume onto the simulation computed tomography using [18 F]-fluorodeoxyglucose positron emission tomography/computed tomography. Material and Methods: The gross target volume delineated on prechemotherapy [18 F]-fluorodeoxyglucose positron emission tomography/computed tomography images was warped onto simulation computed tomography using deformable image registration. Fifteen patients with neck Hodgkin/non-Hodgkin lymphoma were analyzed. Quality of image registration was measured by computing the Dice similarity coefficient on warped organs at risk. Five radiation oncologists visually scored the localization of automatic gross target volume, ranking it from 1 (wrong) to 5 (excellent). Deformable registration was compared to rigid registration by computing the overlap index between the automatic gross target volume and the planned clinical target volume and quantifying the V 95 coverage. Results: The Dice similarity coefficient was 0.80 + 0.07 (median + quartiles). The physicians' survey had a median score equal to 4 (good). By comparing the rigid versus deformable registration, the overlap index increased from a factor of about 4 and the V 95 (percentage of volume receiving the 95% of the prescribed dose) went from 0.84 + 0.38 to 0.99 + 0.10 (median + quartiles). Conclusion: This study demonstrates the impact of using deformable registration between prechemotherapy [ 18 F]-fluorodeoxyglucose positron emission tomography/computed tomography and simulation computed tomography, in order to automatically localize the gross target volume for radiotherapy treatment of patients with Hodgkin/non-Hodgkin lymphoma.

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“…Robertson et al . (2) retrospectively reviewed the role of FDG-PET in 30 pediatric Hodgkin's lymphoma patients treated over a nearly 5 year period and concluded that this functional imaging approach influenced the initial staging and treatment volume. Although the majority of the 546 regions analyzed were in agreement (86%), extranodal sites were found to be problematic.…”

Section: Introductionmentioning

confidence: 99%

Image-Based Biomarkers in Clinical Practice

Bayouth

Casavant

Graham

et al. 2011

Seminars in Radiation Oncology

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The growth of functional and metabolically informative imaging is eclipsing anatomic imaging alone, in clinical practice. The recognition that MR and PET-based treatment planning and response assessment are essential components of clinical practice and furthermore offer the potential of quantitative analysis is important. To extract the greatest benefit from these imaging techniques will require refining the best combinations of multimodality imaging through well designed clinical trials that employ robust image-analysis tools and require substantial computer based infrastructure. Through these changes and enhancements, image-based biomarkers will enhance clinical decision making and accelerate the progress that is made through clinical trial research.

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Role of FDG-PET in the Definition of Involved-Field Radiation Therapy and Management for Pediatric Hodgkin's Lymphoma

Cited by 29 publications

References 28 publications

Impact of PET‐CT on involved field radiotherapy design for pediatric Hodgkin lymphoma

Impact of PET‐CT on involved field radiotherapy design for pediatric Hodgkin lymphoma

Radiotherapy of Hodgkin and Non-Hodgkin Lymphoma

Image-Based Biomarkers in Clinical Practice

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