Role of female reproductive hormones estrogen and progesterone in temporomandibular disorder in female patients

Patil, Santosh; Yadav, Nidhi; Mousa, Mohammed Assayed; Alzwiri, Abdalwhab; Kassab, Mohamed; Sahu, Rajesh Kumar; Chuggani, Satish

doi:10.4103/2249-4987.172492

Cited by 14 publications

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“…Another study with adolescent sample had found the similar gender variation [ 42 ]. The higher prevalence of TMD in females can be attributed to various gender oriented variations including hormonal, anatomical and behavioural [ 43 , 44 ]. Under the influence of estrogens, the laxity of the ligament increases during the preovulatory phase which further gets attenuated with the movement of TMJ leading to irritation of the TMJ joint [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

Evaluation of temporomandibular disorders among dental students of Saudi Arabia using Diagnostic Criteria for Temporomandibular Disorders (DC/TMD): a cross-sectional study

et al. 2021

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Background Temporomandibular disorders (TMD) are a broad category of conditions arising from the various components of the temporomandibular joint complex. Bio-psychosocial model is the most accepted theory describing the etiopathogenesis of TMD. Dental students are vulnerable to psychological disorders, including anxiety, depression, and stress. Hence, the aim of the current study was to evaluate the prevalence and possible risk factors of TMD among dental students of various academic levels and explore the association of TMDs with demographic, academic, and psychosocial parameters. Methods A total of 246 students of a Saudi Arabia dental school were chosen for the study. After getting consent, all students were examined according to the Diagnostic Criteria for Temporomandibular Disorders, including Axis I and II components. Results The overall cross-sectional prevalence of TMD was found to be 36.99%. Pain arising from the jaw, temple, and the peri-auricular area were the most commonly reported symptoms and elicited signs during examination. Among the pain-related TMD, myalgia was the commonest diagnosed condition, whereas disc displacement with reduction was found prevalent in the intra-articular disorder category. Female (OR = 1.94; P = 0.004), married (OR = 1.74; P = 0.04), and students in clinical academic levels (OR = 1.65; P = 0.03) were found to have significantly increased risk of TMD. Among the psychosocial parameters, anxiety (OR = 1.55; P = 0.04) and parafunctional behaviours (OR = 2.10; P < 0.001) were shown to increase the risk of developing TMD. Students with any TMD reported to have significantly higher pain intensity levels (OR = 1.68; P = 0.01) and jaw functional limitations (OR = 1.45; P = 0.008). Conclusion Dental students, especially in clinical levels were shown to pose a higher risk of developing TMD, hence strategies such as academic counselling and objective evaluation via rubrics should be planned to modify the administration of the curriculum, training methods and evaluation process.

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Section: Discussionmentioning

confidence: 99%

Evaluation of temporomandibular disorders among dental students of Saudi Arabia using Diagnostic Criteria for Temporomandibular Disorders (DC/TMD): a cross-sectional study

et al. 2021

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“…Regarding diagnosis among patients, only one study (Patil et al, 2015) did not use the RDC / TMD (Diagnostic Criteria for Research on Temporomandibular Dysfunction) as a method, addressing the anamnesis questionnaire proposed by Fonseca et al 1994. The analysis of hormone levels was performed mainly through blood collection, except for one case (LeResche et al, 2005) where the entire unstimulated saliva was collected for this purpose, as shown in Table 3 below.…”

Section: Resultsmentioning

confidence: 99%

“…Variations in estrogen hormone levels are able to promote sagging joints, especially during pregnancy, and this is believed to have a role in the development of some disorders (Patil et al, 2015). Estrogens act on bone, promoting osteoclastic activity, and cartilage influencing its renewal (Landi et al, 2005).…”

Section: Introductionmentioning

confidence: 99%

“…Estrogens act on bone, promoting osteoclastic activity, and cartilage influencing its renewal (Landi et al, 2005). Inflammatory modulation occurs through the interaction between inflammatory mediators such as histamine, serotonin, platelet-activating factor, and nitric oxide, which act centrally and regionally, influencing bone, joint, and muscle pain (Patil et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

“…Progesterone is related to inflammatory and immunological modulation. Its reduction can induce an exacerbated inflammatory response and its maintenance at normal levels demonstrates a reduction in edema and pain in inflammatory diseases (Patil et al, 2015;. Animal studies have shown a strong relationship between high levels of estrogen and inflammation of the temporomandibular joint through cytokine production (Kou et al, 2011) and an improvement in symptoms caused by increased levels of progesterone .…”

Section: Introductionmentioning

confidence: 99%

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Temporomandibular disorder and serum levels of progesterone and estrogen: Systematic review

Silva¹,

Araújo‐Filho²,

Rêgo³

et al. 2021

RSD

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Temporomandibular Disorder (TMD) is a pathology of the stomatognathic system characterized by a set of clinical disorders that includes a temporomandibular joint, a masticatory musculature and associated structures. It is the most common orofacial pain condition of non-dental origin and which is increasing among adults in the age group between 18 and 45 years with a not well defined etiology, mainly not with regard to its higher prevalence in women than men. The present study aimed to evaluate the literature if there is a relationship between the levels of progesterone and estrogen with the clinical manifestations of TMD. The systematic search was carried out in the following electronic databases: PubMed, Web of Science, SciELO, and LILACS, Scopus, Embase and Google Scholar in addition to a complementary manual search of cross-references of original articles. There was no time restriction. The descriptors used were "TMD" or "TMJ" and "progesterone" and "estrogen". Initially, 132 articles were found, were 15 presented the eligibility criteria to be read in full. In the end, 4 studies were included in the review. The conclusion was that most studies relate the variations of progesterone and estrogen to the symptoms of the disease; however, there are differences between them. Thus, it is recommended to carry out studies that analyze this relationship, leading to hormonal fluctuations ranging from reproductive age to post-menopause.

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Temporomandibular Joint Disorders During Pregnancy and the Postpartum Period

Özel

Özel²

2022

ENT Diseases: Diagnosis and Treatment During Pregnancy and Lactation

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Role of female reproductive hormones estrogen and progesterone in temporomandibular disorder in female patients

Cited by 14 publications

References 0 publications

Evaluation of temporomandibular disorders among dental students of Saudi Arabia using Diagnostic Criteria for Temporomandibular Disorders (DC/TMD): a cross-sectional study

Evaluation of temporomandibular disorders among dental students of Saudi Arabia using Diagnostic Criteria for Temporomandibular Disorders (DC/TMD): a cross-sectional study

Temporomandibular disorder and serum levels of progesterone and estrogen: Systematic review

Temporomandibular Joint Disorders During Pregnancy and the Postpartum Period

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