Role of fibrilins in human cancer: A narrative review

Mahdizadehi, Mahsa; Saghaeian Jazi, Marie; Mir, Seyyed Mostafa; Jafari, Seyyed Mehdi

doi:10.1002/hsr2.1434

Cited by 1 publication

(1 citation statement)

References 61 publications

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“…Delving deeper into the Epithelial-Mesenchymal Transition pathway, the primary influential gene appears to be FBN2, renowned for its inhibition of cancer cell invasion and migration, as stated in Mahdizadehi et al 33 , thereby explaining its inclination toward lower risk outcomes.…”

Section: Customics Can Evaluate Pathway Enrichment For Pancancer Surv...mentioning

confidence: 99%

Multimodal CustOmics: A Unified and Interpretable Multi-Task Deep Learning Framework for Multimodal Integrative Data Analysis in Oncology

Benkirane,

Vakalopoulou,

Planchard

et al. 2024

Preprint

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Characterizing cancer poses a delicate challenge as it involves deciphering complex biological interactions within the tumor's microenvironment. Histology images and molecular profiling of tumors are often available in clinical trials and can be leveraged to understand these interactions. However, despite recent advances in representing multimodal data for weakly supervised tasks in the medical domain, numerous challenges persist in achieving a coherent and interpretable fusion of whole slide images and multi-omics data. Each modality operates at distinct biological levels, introducing substantial correlations both between and within data sources. In response to these challenges, we propose a deep-learning-based approach designed to represent multimodal data for precision medicine in a readily interpretable manner. Demonstrating superior performance compared to state-of-the-art methods across multiple test cases, our approach not only provides robust results but also extracts various scores, shedding light on the activity of each modality and their interactions at the pathway and gene levels. The strengths of our method lie in its capacity to unravel pathway activation through multimodal relationships and extend enrichment analysis to spatial data for supervised tasks. We showcase the efficiency and robustness of its interpretations of our method through an extensive exploration of multiple TCGA datasets and validation cohorts, underscoring its value in advancing our understanding of cancer. The method is publicly available in Github: https://github.com/HakimBenkirane/Multimodal-CustOmics

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Section: Customics Can Evaluate Pathway Enrichment For Pancancer Surv...mentioning

confidence: 99%