Role of Fibrin Glue in palatoplasty to prevent formation of oro-nasal fistula – An in vivo study

Basha, Salman; Srinath, N.; Kumar, Nanda; Balaji, Ravikanth

doi:10.1016/j.ajoms.2011.05.002

Cited by 5 publications

(3 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Use of adjuvant products such as fibrin glue, decellularized dermis, and platelet-rich plasma has proven successful in preventing oronasal fistula following primary palate surgery. Multiple authors reported no fistulas in patients for whom fibrin glue was used (Mommaerts et al, 2006; Basha et al, 2011; Wu et al, 2017). Platelet-rich plasma use was associated with a reduction of oronasal fistula incidence from 13.6% to 0% (El-Anwar et al, 2016).…”

Section: Discussionmentioning

confidence: 99%

On the Frequency of Oronasal Fistulation After Primary Cleft Palate Repair

Tache

Mommaerts

2019

The Cleft Palate Craniofacial Journal

View full text Add to dashboard Cite

Objective: The aims of the study were to assess the postoperative oronasal fistula rate after 1-stage and 2-stage cleft palate repair and identify risk factors associated with its development. Design: Systematic review. Setting: Various primary cleft and craniofacial centers in the world. Patients, Participants: Syndromic and nonsyndromic cleft lip, alveolus, and palate patients who had undergone primary cleft palate surgery. Intervention: Assessment of oronasal fistula frequency and correlation with staging, timing, and technique of repair, gender, and Veau type. The results obtained in this systematic review were compared with those in previous reports. Outcome: The main outcome is represented by the occurrence of the oronasal fistula after 1-stage versus 2-stage palatoplasty. Results: The mean fistula percentage was 9.94%. In the Veau I, II, III, and IV groups, the respective fistula rates were 2%, 7.3%, 8.3%, and 12.5%. Oronasal fistula locations based on the Pittsburgh Fistula Classification System were soft palate (type II), 16.2%; soft palate–hard palate junction (type III), 29.3%; and hard palate (type IV), 37.3%. There were no statistically significant differences between 1-stage and 2-stage palatoplasty, syndromic and nonsyndromic, or male and female patients. Primary palatoplasty timing was not a significant predictor. Conclusion: Some disparities arose when comparing studies, mainly regarding location and types of clefting prone to oronasal fistulation. Interestingly, the fistula rate does not differ between 1- and 2-stage closure, and timing of the repair does not play a role.

show abstract

Section: Discussionmentioning

confidence: 99%

On the Frequency of Oronasal Fistulation After Primary Cleft Palate Repair

Tache

Mommaerts

2019

The Cleft Palate Craniofacial Journal

View full text Add to dashboard Cite

show abstract

“…Many techniques have evolved to achieve the primary goals of palate repair with single operation and primary healing (5) Cleft palate repair is not free of complications.…”

Section: Discussionmentioning

confidence: 99%

A trial to improve the outcome of cleft palate repair in pediatric age by using fibrin glue

Elsadat

El-Dahshan

Holeil

et al. 2023

Egyptian Journal of Medical Research

View full text Add to dashboard Cite

Cleft palate is among the commonest craniofacial abnormality with an incidence of about 1 in every 2000 to 2500 births.Cleft palate repair is a challenging procedure with multiple operations described for the same anomaly. The aim of this study is to improve the outcome of cleft palate repair by using fibrin glue as an adjuvant in the repair with its effect on lowering postoperative complications. A prospective study was carried on 30 patients for primary cleft palate repair operated upon by double flap palatoplasty with the use of human fibrin glue in the repair. Fibrin glue was injected between the oral and nasal layers of palate and at suture line. Six cases showed postoperative complications, with rate of complication 23.3 %, Three of them (10%) were complicated by oronasal palatal fistula. Two of them (6.6%) were small and closed spontaneously within 2 months postoperatively and the third case (3.3%) was presented primarily by local wound infection and later on had showed an oronasal fistula and needed

show abstract

“…Regardless, this study shows that sound, consistent surgical techniques can yield low ONF rates. Basha and colleagues used Von Langenbeck repair and fibrin glue adhesive between the oral and nasal layers as a method to decrease ONF [ 20 ]. They reported a 0% ONF rate in their fibrin glue treatment group vs 30% ONF rate in the control group.…”

Section: Discussionmentioning

confidence: 99%

Palatal Protective Stents Prevent Oro-Nasal Fistulas after Surgery for Velopharyngeal Insufficiency: A Preliminary Report

et al. 2018

View full text Add to dashboard Cite

Background: One of the potential complications of surgery for velopharyngeal insufficiency (VPI) is postoperative oral-nasal fistula (ONF). Reported rates vary from 0 to 60%. Several factors are on account of these disproportionate rates. Objective: The purpose of this study was to describe the use of a palatal protective stent (PPS) to preserve the VPI repair surgical site and to study its effectiveness for decreasing the incidence of postoperative ONF. Materials and Methods: A retrospective study was carried out. All patients undergoing surgery for VPI with complete preoperative and postoperative evaluations including at least one year follow up after surgery from 2012 to 2016 were studied. Some of the patients were operated on using a pre-molded palatal protective stent (PPS). Twenty-seven patients were included in the study group. Most of the patients underwent a customized pharyngeal flap according to findings of imaging procedures. The remaining cases underwent a Furlow palatoplasty. Twelve patients were operated on using PPS. Results: There were no surgical complications during the procedures. ONF was detected in four of the patients operated on without PPS. None of the patients undergoing surgery using PPS demonstrated ONF. All fistulas were located at the soft/hard palate junction. VPI was corrected in 92% of the cases. Conclusion: Although only a reduced number of cases were studied, these preliminary results suggest that using PPS during surgical procedures for correcting VPI is a safe and reliable tool for preventing ONF.

show abstract

Role of Fibrin Glue in palatoplasty to prevent formation of oro-nasal fistula – An in vivo study

Cited by 5 publications

References 11 publications

On the Frequency of Oronasal Fistulation After Primary Cleft Palate Repair

On the Frequency of Oronasal Fistulation After Primary Cleft Palate Repair

A trial to improve the outcome of cleft palate repair in pediatric age by using fibrin glue

Palatal Protective Stents Prevent Oro-Nasal Fistulas after Surgery for Velopharyngeal Insufficiency: A Preliminary Report

Contact Info

Product

Resources

About