Role of Fine Needle Aspiration Cytology in Nodular Sclerosis Variant of Hodgkin’s Lymphoma

Jogai, Sanjay; Dey, Pranab; Jassar, Aisha Al; Amanguno, Henney G.; Adesina, Aaron O.

doi:10.1159/000326004

Cited by 16 publications

(7 citation statements)

References 16 publications

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“…Lacunar Hodgkin/RS cells have been described in imprint cytology as multilobated cells with fine chromatin, multiple small‐ to medium‐sized nucleoli, and abundant vacuolated cytoplasm . Jogai et al also described lacunar cells in cases of NSCHL. RS cells are 20 to 30 µm in diameter with a binucleate or bilobed nucleus, a prominent eosinophilic nucleolus giving an owl‐eye appearance, and basophilic cytoplasm.…”

Section: Discussionmentioning

confidence: 93%

Nodular sclerosis classical Hodgkin lymphoma grade 2: A diagnostic challenge to the cytopathologists

Sharma

Dey

Mitra

et al. 2016

Cancer Cytopathology

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Section: Discussionmentioning

confidence: 93%

Nodular sclerosis classical Hodgkin lymphoma grade 2: A diagnostic challenge to the cytopathologists

Sharma

Dey

Mitra

et al. 2016

Cancer Cytopathology

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“…The sampling error is a particular hazard in Hodgkin lymphoma nodular sclerosis subtype possibly because of the fibrosis that interferes with the cell yield [27]. However, sampling error is uncommon in actual practice because varying the angle of entry of the aspirated needle with each pass usually adequately samples the majority of enlarged lymph nodes [2].…”

Section: Discussionmentioning

confidence: 99%

Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy

Hafez

Tahoun

2011

Journal of the Egyptian National Cancer Institute

105

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The overall diagnostic accuracy of FNAC of cervical lymph nodes was 82.2% while the overall discordance rate was 17.8%. The evaluation of FNA in patients with no previously diagnosed malignancy should be interpreted by an experienced cytopathologist in the context of clinical, radiological, and laboratory finding and if any of these findings is suspicious, further investigation is justified to overcome the limitations and pitfalls of the cytomorphological features when applied alone.

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“…In this review article, 22 difficulty in diagnosis of nodular sclerosis (NS) variant has been ascribed to the paucity or absence of fibrocollagenous bands in FNA material and nonrecognition of cytologic counterpart of lacunar type R-S cells. According to Jogai et al 23 also, nodular sclerosis variant of HL poses the greatest diagnostic difficulty. In this study, it was further observed that 61.9% of the histological diagnosis was NS subtype in cytohisto concordant group and it was 33.3% in the discordant group (P ¼ 0.1215).…”

Section: Discussionmentioning

confidence: 99%

Hodgkin's lymphoma: Diagnostic difficulties in fine‐needle aspiration cytology

Das

Francis

Sharma

et al. 2009

Diagnostic Cytopathology

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It is commonly believed that cytodiagnosis of Hodgkin's lymphoma (HL) is much easier than that of non-Hodgkin lymphoma (NHL). However, recognition of certain NHL subtypes with Reed-Sternberg (R-S)-like cells and results of immunohistochemical studies point to the contrary. To study the limitations of cytology in diagnosis of HL, fine-needle aspiration (FNA) smears of 130 lymphoma or suspected lymphoma cases were reviewed. Initial and reviewed cytodiagnoses were compared with histopathology in 89 cases. Immunocytochemical and immunohistochemical studies were performed in 56 and 59 cases, respectively. Among histologically diagnosed HL cases, definitive cytodiagnosis of HL (initial as well as reviewed) was significantly less frequent than cytodiagnosis of NHL among histologically diagnosed NHL cases (P = 0.0328 and = 0.0001, respectively). On the other hand, cytologically diagnosed HL/NHL cases were significantly more frequent in the former group (P = 0.0001 and = 0.0018, respectively). ALCL and TCRBCL were the two NHL subtypes which created confusion with HL in FNA smears. Twenty-one cytohistological concordant HL cases and equal number of discordant cases were compared. When compared with discordant group, the patients in concordant group were significantly younger (P = 0.045). Hodgkin/Hodgkin-like cells and typical R-S cells were significantly more frequent in FNA smears of the concordant group (P = 0.0478 and = 0.0431, respectively). Immunocytochemical and immunohistochemical studies showed good correlation with histological diagnosis of HL. It is suggested that proper interpretation of cytologic features, together with use of immunocytochemical parameters can help in reducing the margin of error in cytodiagnosis of HL.

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Role of Fine Needle Aspiration Cytology in Nodular Sclerosis Variant of Hodgkin’s Lymphoma

Cited by 16 publications

References 16 publications

Nodular sclerosis classical Hodgkin lymphoma grade 2: A diagnostic challenge to the cytopathologists

Nodular sclerosis classical Hodgkin lymphoma grade 2: A diagnostic challenge to the cytopathologists

Reliability of fine needle aspiration cytology (FNAC) as a diagnostic tool in cases of cervical lymphadenopathy

Hodgkin's lymphoma: Diagnostic difficulties in fine‐needle aspiration cytology

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