Role of Fine Needle Aspiration Cytology in the Diagnosis of Gynecologic Tumors

Goyal, Abha

doi:10.1159/000529364

Cited by 4 publications

(2 citation statements)

References 63 publications

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“…Gynecologic neoplasms comprise lesions of different origin such as epithelial, mesenchymal, sex cord-stromal, and germ cell. Of these categories, 75% is represented by high-grade serous ovarian carcinoma (HGSOC), with a poor survival [ 5 , 6 ]. Comparative transcriptomic and genomic studies of mouse models and organoids suggest that extracellular matrix in HGSOC, despite its name, originates from both the fallopian tube epithelium and the ovarian surface epithelium [ 7 ].…”

Section: Introductionmentioning

confidence: 99%

Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis

Anastasi,

Farina,

Granato

et al. 2023

IJMS

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Currently, ovarian cancer (OC) is a target of intense biomarkers research because of its frequent late diagnosis and poor prognosis. Serum determination of Human epididymis protein 4 (HE4) is a very important early detection test. Most interestingly, HE4 plays a unique role in OC as it has been implicated not only in OC diagnosis but also in the prognosis and recurrence of this lethal neoplasm, actually acting as a clinical biomarker. There are several evidence about the predictive power of HE4 clinically, conversely less has been described concerning its role in OC oncogenesis. Based on these considerations, the main goal of this review is to clarify the role of HE4 in OC proliferation, angiogenesis, metastatization, immune response and also in the development of targeted therapy. Through a deeper understanding of its functions as a key molecule in the oncogenetic processes underlying OC, HE4 could be possibly considered as an essential resource not only for diagnosis but also for prognosis and therapy choice.

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Section: Introductionmentioning

confidence: 99%

Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis

Anastasi,

Farina,

Granato

et al. 2023

IJMS

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“…FNAC is a minimally invasive way of obtaining diseased tissue and has achieved widespread application in the diagnosis of many sites and types of tumors (6)(7)(8). Combined with various assistive techniques, the correctness of the FNAC diagnosis is comparable to that of histopathological biopsy for some kinds of tumors (6,9).…”

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confidence: 99%

Case report: Lymph node metastasis of pelvic alveolar rhabdomyosarcoma diagnosed by fine needle aspiration cytology

Hu,

Huang,

et al. 2024

Front. Oncol.

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Rhabdomyosarcoma (RMS) is a common soft tissue malignant tumor, especially in young patients. Alveolar rhabdomyosarcoma (ARMS) is a subtype of RMS that is prevalent in adolescents. This malignant tumor usually develops in the extremities and can also involve the trunk, perineum, and pelvis. Now, we report a rare case of pelvic lymph node metastatic alveolar RMS in a young patient, which was determined by fine needle aspiration cytology (FNAC). To the best of our knowledge, this is the first case in which the definite diagnosis of ARMS was initially made by FNAC.

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Guidelines of the Brazilian Society of Surgical Oncology for anatomopathological, immunohistochemical, and molecular testing in female tumors

Ribeiro,

Carvalho,

Baiocchi

et al. 2024

Journal of Surgical Oncology

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IntroductionPrecision medicine has revolutionized oncology, providing more personalized diagnosis, treatment, and monitoring for patients with cancer. In the context of female‐specific tumors, such as breast, ovarian, endometrial, and cervical cancer, proper tissue collection and handling are essential for obtaining tissue, immunohistochemical (IHC), and molecular data to guide therapeutic decisions.ObjectivesTo establish guidelines for the collection and handling of tumor tissue, to enhance the quality of samples for histopathological, IHC, genomic, and molecular analyses. These guidelines are fundamental in informing therapeutic decisions in cancer treatment.MethodThe guidelines were developed by a multidisciplinary panel of renowned specialists between June 12, 2013 and February 12, 2024. Initially, the panel deliberated on critical and controversial topics related to conducting precision medicine studies focusing on female tumors. Subsequently, 22 pivotal topics were identified within the framework and assigned to groups. These groups reviewed relevant literature and drafted preliminary recommendations. Following this, the recommendations were reviewed by the coordinators and received unanimous approval. Finally, the groups made the final adjustments, classified the level of evidence, and ranked the recommendations.ConclusionThe collection of surgical samples requires minimum quality standards to enable histopathological, IHC, genomic, and molecular analyses. These analyses provide crucial data for informing therapeutic decisions, significantly impacting potential survival gains for patients with female tumors.

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Role of Fine Needle Aspiration Cytology in the Diagnosis of Gynecologic Tumors

Cited by 4 publications

References 63 publications

Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis

Recent Insight about HE4 Role in Ovarian Cancer Oncogenesis

Case report: Lymph node metastasis of pelvic alveolar rhabdomyosarcoma diagnosed by fine needle aspiration cytology

Guidelines of the Brazilian Society of Surgical Oncology for anatomopathological, immunohistochemical, and molecular testing in female tumors

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