Role of Flavonoids as Wound Healing Agent

Aslam, Muhammad Shahzad; Ahmad, Muhammad Syarhabil; Riaz, Humayun; Raza, Syed Atif; Hussain, Shahzad; SalmanQureshi, Omer; Maria, Povydysh; Hamzah, Zainab; Javed, Osama

doi:10.5772/intechopen.79179

Cited by 26 publications

(16 citation statements)

References 35 publications

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“…These compounds were found to act via inhibition of elastase and collagenase, two enzymes, which are commonly over‐expressed in wound settings (Morena et al, 2020). In addition to enzyme inhibition, phenolic and flavonoid compounds often aid wound healing due to their antioxidant properties, which assist in restoring redox imbalance in the wound environment (Aslam et al, 2018; Ibrahim et al, 2018; Johnson, Broszczak, Mani, Anesi, & Naiker, 2021). This multi‐faceted mode of action greatly improves the efficacy of these compounds for the treatment of wounds.…”

Section: Discussionmentioning

confidence: 99%

Hitting the sweet spot: A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants

Johnson

Mani

Broszczak

et al. 2021

Phytotherapy Research

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Phenolic acid and flavonoid glycosides form a varied class of naturally occurring compounds, characterised by high polarity-resulting from the glycone moiety-and the presence of multiple phenol functionalities, which often leads to strong antioxidant activity.Phenolic glycosides, and in particular flavonoid glycosides, may possess strong bioactive properties with broad spectrum activity. This systematic literature review provides a detailed overview of 28 studies examining the biological activity of phenolic and flavonoid glycosides from plant sources, highlighting the potential of these compounds as therapeutic agents. The activity of glycosides depends upon the biological activity type, identity of the aglycone and the identity and specific location of the glycone moiety. From studies reporting the activity of both glycosides and their respective aglycones, phenolic glycosides appear to generally be a storage/reserve pool of precursors of more bioactive compounds. The glycosylated compounds are likely to be more bioavailable compared to their aglycone forms, due to the presence of the sugar moieties. Hydrolysis of the glycoside in the in vivo environment would release the free aglycone, potentiating their biological activity. However, further high-quality studies are needed to firmly establish the clinical efficacy of glycosides from many of the plant species studied.

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Section: Discussionmentioning

confidence: 99%

Hitting the sweet spot: A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants

Johnson

Mani

Broszczak

et al. 2021

Phytotherapy Research

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“…According to these results, it is evident that species with the presence of flavonoids contribute to wound healing (Aslam et al, 2018).…”

Section: Discussionmentioning

confidence: 85%

Antioxidant effect of Hymenaea courbaril L (Jatob) sap on the healing of wounds on mice

Costa¹,

Martins²,

Peixoto³

et al. 2021

J. Med. Plants Res.

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The use of natural products with curative action is a common cultural practice in the Brazilian Amazon, but little explored scientifically. The effect of Hymenaea courbaril L sap extract and its contribution to wound healing in mice was evaluated. The antioxidant potential of the extract was studied using the radical 1,1-diphenyl-2-picrilhidrazil and 2,2'-azino-bis (3-ethyl benzothiazoline-6-sulfonic) acid radical, anion superoxide (O2-) radical tests, phenol and flavonoid content, proliferation assay, cell viability and migration. In vivo tests were performed on adult Swiss mice, submitted to back injury and treated with a formulation containing 2% sap extract, extracted with ethyl acetate. The animals were treated topically for 14 days, it was observed that the sap extract has antioxidant activity, inhibiting the production of reactive oxygen species, presented potential for the proliferation of fibroblasts and promoted cell migration. Morphometric analysis of wound closure on the 3rd day suggested that animals treated with Jatobá sap had a reduced area of injury when compared with the control group on the 3rd post-injury day for the treated group. On the 14th day, there was no difference between groups. The total closure of the wounds did not occur during the 14-day experiment, but through histological evaluation, it was found that there was re-epithelialization. The results suggest that Jatobá sap extract has the potential to induce the healing of skin wounds due to its antioxidant activity.

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“…In addition, rutin improves production and accumulation of extracellular matrix in the wound healing process. It induces better neopithelium formation and thicker granulation, which is closer to the original epithelial tissue (32).…”

Section: Discussionmentioning

confidence: 86%

Phytochemical profile, acute dermal toxicity and wound healing activity of Guettarda calyptrata A. Rich

Gaitén

Norden

Lizama

et al. 2021

J Herbmed Pharmacol

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Introduction: The leaves and barks of Guettarda calyptrata have been attributed to the property of healing wounds on the skin and mucous membranes. However, the scientific information about the phytochemical composition and biological properties is scarce. This research evaluates the chemical composition, dermal safety, and wound healing properties of a hydroalcoholic extract of G. calyptrata. Methods: Hydroalcoholic extract of G. calyptrata was obtained from leaves. The phytochemical profile was analyzed by phytochemical screening, thin layer chromatography, high performance liquid chromatography (HPLC), and quantification of phenols and flavonoids by Folin-Ciocalteu and aluminum chloride methods, respectively. An acute dermal toxicity test was performed in rats, and the healing activity was evaluated using the excision wound model at 100 mg/kg of the extracts. Statistical significance (P < 0.05) was determined by an analysis of variance followed by the Student-Newman-Keuls test. Results: The presence of alkaloids, saponins, terpenoids, phenolic compounds, rutin, and quercetin flavonoids, among others, was suggested. The extract did not cause toxicity at the dose of 2000 mg/kg and was able to reduce the size of the wounds during the seven days of the test, with a healing effect comparable to the silver sulfadiazine cream used as a positive control, favoring collagen deposition and re-epithelialization. Conclusion: This work makes an important contribution to the chemical composition and provides the first findings on the efficacy in the healing of topical wounds, which justify the use of G. calyptrata in traditional Cuban medicine.

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Role of Flavonoids as Wound Healing Agent

Cited by 26 publications

References 35 publications

Hitting the sweet spot: A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants

Hitting the sweet spot: A systematic review of the bioactivity and health benefits of phenolic glycosides from medicinally used plants

Antioxidant effect of Hymenaea courbaril L (Jatob) sap on the healing of wounds on mice

Phytochemical profile, acute dermal toxicity and wound healing activity of Guettarda calyptrata A. Rich

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