Role of flavonoids in age-related macular degeneration

Sun, Mengmeng; Yu, Tao; Zhao, Jianzhou; Zhu, Xuan; Xin, Wenyu; Zhang, Fenglan; Zhang, Leiming

doi:10.1016/j.biopha.2023.114259

Cited by 11 publications

(6 citation statements)

References 128 publications

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“…Flavonoids act by decreasing oxidative stress and inflammatory processes, and by producing angiogenesis inhibitors. A regular diet rich in these compounds can have a relevant role in the prevention of AMD, and in inhibiting the progression of AMD [37]. Epigallocatechin gallate, found in green tea, inhibits ROS, angiogenesis, VEGF, apoptosis of retinal ganglion cells, and protects against mitochondrial damage.…”

Section: Discussionmentioning

confidence: 99%

“…Anthocyanins are present in blueberries, raspberries, blackberries, strawberries, or red grapes. One flavonoid reduces the inflammation process in chronic conditions-namely, cyanidin-3-glucoside (C3G) that is important in the prevention of retinal diseases [37]. Anthocyanins and their protective role could be linked to antioxidative and anti-inflammatory properties related to ROS generated induced by light exposure [12].…”

Section: Discussionmentioning

confidence: 99%

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The Roles of Vitamin D and Polyphenols in the Management of Age-Related Macular Degeneration: A Narrative Review

Fernandes

Araújo²,

Lança

2023

Future Pharmacology

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Age-related macular degeneration (AMD) is a chronic progressive ocular disease and the main cause of severe visual impairment in the elderly. Vitamin D deficiency may be a risk factor for AMD. Additionally, current evidence suggests dietary advice of increasing consumption of polyphenols, which may have antioxidant and anti-inflammatory properties. The aim of this review was to describe the roles of vitamin D levels and polyphenols in the management of AMD. The results of this review showed mixed evidence regarding the protective effect of vitamin D against AMD. Polyphenols (flavonoids group, curcumin and resveratrol) seem to play an important role as angiogenesis inhibitors, but their effect on AMD is still unclear. Vitamin D and polyphenols may both play an important role as nutritional modifiable protective factors that reduce the risk of AMD progression. However, more research is necessary to better understand the roles of vitamin D and polyphenols in different stages of the disease.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

The Roles of Vitamin D and Polyphenols in the Management of Age-Related Macular Degeneration: A Narrative Review

Fernandes

Araújo²,

Lança

2023

Future Pharmacology

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“…Flavonoids reduce the effects of harmful bacteria. Hesperidin-7-O-glucoside, naringenin, and lisin all significantly reduce the levels of Haemophilus and the relative abundance of harmful bacteria, such as Clostridium pullulans and Bacteroides , suggesting that flavonoids can regulate signaling pathways, such as TLR4/NF-κB, NOD-like receptor family pyrin domain containing 3, and MAPK, along with the expression of the genes encoding matrix metalloproteinase-9, IL-1β, IL-6, IL-8, soluble intercellular adhesion molecule-1, MCP-1, and other inflammatory factors, suppressing the inflammatory response ( Sun et al, 2023 ). The presence of flavonols, a type of flavonoid, facilitates the proliferation of beneficial bacteria, such as Lactobacillus and Bifidobacterium , while diminishing the presence of Clostridium spp.…”

Section: Therapeutic Intervention For Amd With Tcmmentioning

confidence: 99%

“…Natural flavonoid products also have antioxidant properties that reduce oxidative stress and inhibit the activation of various signaling pathways to ameliorate inflammatory diseases. By improving the dysregulation of intestinal dynamic homeostasis in vivo , ROS production is reduced, the AKT/glycogen synthase kinase-3-beta (GSK-3β) and Nuclear factor erythroid-derived-2-like 2 (Nrf2)/antioxidant response element (ARE) signaling pathways are directly altered, and the expression of antioxidant genes, such as NAD ( P ) H quinone oxidoreductase 1, heme oxygenase-1, glutamate-cysteine ligase modifier, glutathione , and superoxide dismutase ( SOD ), are regulated ( Sun et al, 2023 ).…”

Section: Therapeutic Intervention For Amd With Tcmmentioning

confidence: 99%

Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

Yu,

Liu,

Meng

2024

Front. Pharmacol.

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The pathogenesis of age-related macular degeneration (AMD), a degenerative retinopathy, remains unclear. Administration of anti-vascular endothelial growth factor agents, antioxidants, fundus lasers, photodynamic therapy, and transpupillary warming has proven effective in alleviating symptoms; however, these interventions cannot prevent or reverse AMD. Increasing evidence suggests that AMD risk is linked to changes in the composition, abundance, and diversity of the gut microbiota (GM). Activation of multiple signaling pathways by GM metabolites, including lipopolysaccharides, oxysterols, short-chain fatty acids (SCFAs), and bile acids (BAs), influences retinal physiology. Traditional Chinese medicine (TCM), known for its multi-component and multi-target advantages, can help treat AMD by altering GM composition and regulating the levels of certain substances, such as lipopolysaccharides, reducing oxysterols, and increasing SCFA and BA contents. This review explores the correlation between GM and AMD and interventions for the two to provide new perspectives on treating AMD with TCM.

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“…Defective treatment of dry AMD and exudative wet AMD conditions results in fibrosis and severe vision loss [14]. Both variants equally lead to RPE destruction and consequent loss of photoreceptors and visual capacity failure, mainly of central vision (reviewed in [20]). Several pharmacological approaches are used to treat wet AMD once it is a chronic and multifactorial disease.…”

Section: Age-related Macular Degeneration (Amd)mentioning

confidence: 99%

Revisiting Retinal Degeneration Hallmarks: Insights from Molecular Markers and Therapy Perspectives

Rosa,

Disner,

Pinto

et al. 2023

IJMS

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Visual impairment and blindness are a growing public health problem as they reduce the life quality of millions of people. The management and treatment of these diseases represent scientific and therapeutic challenges because different cellular and molecular actors involved in the pathophysiology are still being identified. Visual system components, particularly retinal cells, are extremely sensitive to genetic or metabolic alterations, and immune responses activated by local insults contribute to biological events, culminating in vision loss and irreversible blindness. Several ocular diseases are linked to retinal cell loss, and some of them, such as retinitis pigmentosa, age-related macular degeneration, glaucoma, and diabetic retinopathy, are characterized by pathophysiological hallmarks that represent possibilities to study and develop novel treatments for retinal cell degeneration. Here, we present a compilation of revisited information on retinal degeneration, including pathophysiological and molecular features and biochemical hallmarks, and possible research directions for novel treatments to assist as a guide for innovative research. The knowledge expansion upon the mechanistic bases of the pathobiology of eye diseases, including information on complex interactions of genetic predisposition, chronic inflammation, and environmental and aging-related factors, will prompt the identification of new therapeutic strategies.

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Role of flavonoids in age-related macular degeneration

Cited by 11 publications

References 128 publications

The Roles of Vitamin D and Polyphenols in the Management of Age-Related Macular Degeneration: A Narrative Review

The Roles of Vitamin D and Polyphenols in the Management of Age-Related Macular Degeneration: A Narrative Review

Role of traditional Chinese medicine in age-related macular degeneration: exploring the gut microbiota’s influence

Revisiting Retinal Degeneration Hallmarks: Insights from Molecular Markers and Therapy Perspectives

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