Role of food nutrients and supplementation in fighting against viral infections and boosting immunity: A review

Thirumdas, Rohit; Kothakota, Anjineyulu; Pandiselvam, R.; Bahrami, Arash; Barba, Francisco J.

doi:10.1016/j.tifs.2021.01.069

Cited by 69 publications

(50 citation statements)

References 123 publications

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“…Each of the vitamins or combination of them is required for inducing a distinct stage of the immune response. For instance, vitamins A, D, E, and C have a notable role in the modification of the immune system [ 69 , 70 ]. The following contexts briefly introduce the most important vitamins and minerals related to the COVID-19 treatment and control.…”

Section: Vitamins and Minerals In The Immune Functionmentioning

confidence: 99%

Micronutrient therapy and effective immune response: a promising approach for management of COVID-19

et al. 2021

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The escalating prevalence of coronavirus disease 2019 (COVID-19) worldwide, with an increased rate of morbidity and mortality, highlights an urgent need to develop more effective therapeutic interventions. Despite the authorized treatment against COVID-19 by the European Union (EU), the safety and effectiveness of this therapeutic strategy for a wide variety of patients have remained a significant challenge. In this respect, micronutrients such as vitamins and minerals, as essential factors, can be considered for improving the function of the immune system and accelerating the treatment procedure. Dietary supplements can attenuate vascular and inflammatory manifestations related to infectious diseases in large part due to their anti-inflammatory and antioxidant properties. Recently, it has been revealed that poor nutritional status may be one of the notable risk factors in severe COVID-19 infections. In the current review, we focus on the micronutrient therapy of COVID-19 patients and provide a comprehensive insight into the essential vitamins/minerals and their role in controlling the severity of the COVID-19 infection. We also discuss the recent advancements, challenges, negative and positive outcomes in relevance to this approach.

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Section: Vitamins and Minerals In The Immune Functionmentioning

confidence: 99%

Micronutrient therapy and effective immune response: a promising approach for management of COVID-19

et al. 2021

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“…During the ongoing pandemic, benefits of balanced nutrition, dietary supplements, nutraceuticals, plant extracts, medicinal herbs, traditional medicines, and other alternative/supportive regimens have also gained momentum owing to their promising ability to boost immunity and to promote better health and possessing antiviral properties and, therefore, have revealed a potential role in managing and treating patients infected with COVID-19 (96)(97)(98)(99)(100)(101). Alternative and supportive approaches to prevent and control the spread of the pandemic disease are in urgent need.…”

Section: Therapeutics and Vaccinesmentioning

confidence: 99%

Egypt's COVID-19 Recent Happenings and Perspectives: A Mini-Review

Saied

Metwally

Madkhali

et al. 2021

Front. Public Health

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The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has affected countries across the world. While the zoonotic aspects of SARS-CoV-2 are still under investigation, bats and pangolins are currently cited as the animal origin of the virus. Several types of vaccines against COVID-19 have been developed and are being used in vaccination drives across the world. A number of countries are experiencing second and third waves of the pandemic, which have claimed nearly four million lives out of the 180 million people infected globally as of June 2021. The emerging SARS-CoV-2 variants and mutants are posing high public health concerns owing to their rapid transmissibility, higher severity, and in some cases, ability to infect vaccinated people (vaccine breakthrough). Here in this mini-review, we specifically looked at the efforts and actions of the Egyptian government to slow down and control the spread of COVID-19. We also review the COVID-19 statistics in Egypt and the possible reasons behind the low prevalence and high case fatality rate (CFR%), comparing Egypt COVID-19 statistics with China (the epicenter of COVID-19 pandemic) and the USA, Brazil, India, Italy, and France (the first countries in which the numbers of patients infected with COVID-19). Additionally, we have summarized the SARS-CoV-2 variants, vaccines used in Egypt, and the use of medicinal plants as preventive and curative options.

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“…[86][87][88] Furthermore, COVID-19 has been found to persuade inflammatory response/cytokine storms, especially involving liver, lung, and kidney, which further increases the risk of depletion of vitamin A stores that demand supplementation and has the prospect to restore the acceptable status and combat the grave lifethreatening disease. 88,89…”

Section: Role Of Vitamin a In Covid-19mentioning

confidence: 99%

Fat-Soluble Vitamins and the Current Global Pandemic of COVID-19: Evidence-Based Efficacy from Literature Review

Samad¹,

Dutta²,

Sodunke³

et al. 2021

JIR

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The outbreak of pneumonia caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), later named COVID-19 by the World Health Organization (WHO), was initiated at Wuhan, Hubei, China, and there was a rapid spread of novel SARS-CoV-2 and the disease COVID-19 in late 2019. The entire world is now experiencing the challenge of COVID-19 infection. However, still very few evidence-based treatment options are available for the prevention and treatment of COVID-19 disease. The present review aims to summarize the publicly available information to give a comprehensive yet balanced scientific overview of all the fat-soluble vitamins concerning their role in SARS-CoV-2 virus infection. The roles of different fat-soluble vitamins and micronutrients in combating SARS-CoV-2 infection have been recently explored in several studies. There are various hypotheses to suggest their use to minimize the severity of COVID-19 infection. These vitamins are pivotal in the maintenance and modulation of innate and cell-mediated, and antibody-mediated immune responses. The data reported in recent literature demonstrate that deficiency in one or more of these vitamins compromises the patients' immune response and makes them more vulnerable to viral infections and perhaps worse disease prognosis. Vitamins A, D, E, and K boost the body's defense mechanism against COVID-19 infection and specifically prevent its complications such as cytokine storm and other inflammatory processes, leading to increased morbidity and mortality overemphasis. However, more detailed randomized double-blind clinical pieces of evidence are required to define the use of these supplements in preventing or reducing the severity of the COVID-19 infection.

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Role of food nutrients and supplementation in fighting against viral infections and boosting immunity: A review

Cited by 69 publications

References 123 publications

Micronutrient therapy and effective immune response: a promising approach for management of COVID-19

Micronutrient therapy and effective immune response: a promising approach for management of COVID-19

Egypt's COVID-19 Recent Happenings and Perspectives: A Mini-Review

Fat-Soluble Vitamins and the Current Global Pandemic of COVID-19: Evidence-Based Efficacy from Literature Review

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