Role of four-week resistance exercise in preserving the heart against ischaemia-reperfusion-induced injury : cardiovascular topic

Doustar, Yousef; Soufi, Farhad Ghadiri; Jafary, Afshar; Saber, Mohaddeseh Mahmoudi; Ghiassie, Rafigheh

doi:10.5830/cvja-2012-050

Cited by 13 publications

(14 citation statements)

References 20 publications

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“…A previous study by Doustar et al ( 17 ), using another RT model (climbing a vertical ladder), showed that 4 weeks of RT did not preserve the heart against ischemia-reperfusion injury, evidenced by no change in the infarct size. Quinteiro et al ( 23 ) showed that only eight weeks of dynamic aerobic exercise training, but not RT (climbing a vertical ladder), was able to attenuate systolic and diastolic dysfunction in postmenopausal rats with diabetes.…”

Section: Discussionmentioning

confidence: 91%

“…Our group has previously characterized the cardiovascular adaptations of this type of exercise in animal models, such as concentric ventricular hypertrophy without LV internal chamber reduction and the participation of AT1R, decreased resting BP and improved single LV myocyte function ( 12 – 15 ). Other groups have used the same model to study the influence of RT on bone mass and insulin resistance, and as non-pharmacological therapy for the treatment of ischemia-reperfusion-induced injury ( 16 , 17 ).…”

Section: Introductionmentioning

confidence: 99%

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Resistance training attenuates salt overload-induced cardiac remodeling and diastolic dysfunction in normotensive rats

Barretti

Melo

Oliveira

et al. 2017

Braz J Med Biol Res

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Elevated salt intake induces changes in the extracellular matrix collagen, leading to myocardial stiffness and impaired relaxation. Resistance training (RT) has been used as a remarkably successful strategy in the treatment of heart disease. Therefore, the aim of this study was to investigate the effects of RT on preventing pathological adaptation of the left ventricle (LV) induced by salt overload. Male Wistar rats (10 weeks old) were distributed into four groups (n=8/group): control (CO), control+1% salt (CO+SALT), RT and RT+1% salt (RT+SALT). The RT protocol consisted of 4×12 bouts of squat training, 5/week for 8 weeks, with 80% of one repetition maximum (1RM). Echocardiographs were analyzed and interstitial collagen volume fraction (CVF) was determined in the LV. The 1RM tests in the RT and RT+SALT groups increased 145 and 137%, respectively, compared with the test performed before the training program. LV weight-to-body weight ratio and LV weight-to-tibia length ratio were greater in the RT and RT+SALT groups, respectively, compared with the CO group. Although there was no difference in the systolic function between groups, diastolic function decreased 25% in the CO+SALT group compared with the CO group measured by E/A wave ratio. RT partially prevented this decrease in diastolic function compared with the CO+SALT group. A 1% salt overload increased CVF more than 2.4-fold in the CO+SALT group compared with the CO group and RT prevented this increase. In conclusion, RT prevented interstitial collagen deposition in LV rats subjected to 1% NaCl and attenuated diastolic dysfunction induced by salt overload independent of alterations in blood pressure.

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Section: Discussionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 99%

Resistance training attenuates salt overload-induced cardiac remodeling and diastolic dysfunction in normotensive rats

Barretti

Melo

Oliveira

et al. 2017

Braz J Med Biol Res

View full text Add to dashboard Cite

show abstract

“…To our knowledge, the present investigation is one of the first studies to have measured I/R‐injury in resistance exercised animals with T1DM. Doustar et al ( 2012 ) examined the impact of a 4‐week resistance training program on I/R‐injury in healthy rats and reported no exercise‐related benefits. However, in a subsequent study it was demonstrated that 12 weeks of resistance training led to significant improvements in coronary flow, developed pressure, diastolic pressure, and infarct size, suggesting that this form of exercise can be effective for cardiac protection (Soufi et al 2011 ).…”

Section: Discussionmentioning

confidence: 99%

Ischemia-reperfusion injury and hypoglycemia risk in insulin-treated T1DM rats following different modalities of regular exercise

et al. 2014

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While regular exercise is known to improve cardiovascular function, individuals with type 1 diabetes mellitus (T1DM) have an increased risk for exercise‐induced hypoglycemia. Clinical data suggest that higher intensities of acute exercise may alleviate the onset of hypoglycemia; however, the cardiovascular benefit from these forms of exercise in patients with T1DM has yet to be established. The purpose of this study was to investigate the cardiovascular benefit of different regular exercise regimes, while monitoring blood glucose concentrations during the post‐exercise period. Fifty rats (8‐week‐old Sprague–Dawley male) were equally divided into the following groups: nondiabetic sedentary (C), diabetic sedentary (DS), diabetic low‐intensity aerobic exercise (DL), diabetic high‐intensity aerobic exercise (DH) or diabetic resistance exercise (DR). Diabetes was induced using multiple streptozotocin injections (5×; 20 mg/kg) while subcutaneous insulin pellets maintained glycemia in a range typical for individuals that exercise with T1DM. Exercise consisted of six weeks of treadmill running (DL and DH) or weighted ladder climbs (DR). The cardiovascular benefit of each exercise program was determined by the myocardial recovery from ischemia‐reperfusion injury. Exercise‐related cardiovascular protection was dependent on the exercise modality, whereby DH demonstrated the greatest protection following an ischemic‐reperfusion injury. Each exercise modality caused a significant decline in blood glucose in the post‐exercise period; however, blood glucose levels did not reach hypoglycemic concentrations (<3.0 mmol/L) throughout the exercise intervention. These results suggest that elevating blood glucose concentrations prior to exercise allows patients with T1DM to perform exercise that is beneficial to the myocardium without the accompanying risk of hypoglycemia.

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“…Nonetheless, two studies have investigated the potential benefit of resistance exercise training on cardioprotection in rodents. While one study concluded that resistance training does not result in cardioprotection (32), another investigation, using a longer duration (i.e., 12 wk) of resistance training, showed that resistance training can result in a small, but significant, level of defense against IR-induced myocardial infarction (134). Obviously, additional studies are required to substantiate the influence of resistance training on cardioprotection.…”

Section: Exercise-induced Cardioprotectionmentioning

confidence: 99%

Exercise: Teaching myocytes new tricks

Powers

2017

Journal of Applied Physiology

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Endurance exercise training promotes numerous cellular adaptations in both cardiac myocytes and skeletal muscle fibers. For example, exercise training fosters changes in mitochondrial function due to increased mitochondrial protein expression and accelerated mitochondrial turnover. Additionally, endurance exercise training alters the abundance of numerous cytosolic and mitochondrial proteins in both cardiac and skeletal muscle myocytes, resulting in a protective phenotype in the active fibers; this exercise-induced protection of cardiac and skeletal muscle fibers is often referred to as "exercise preconditioning." As few as 3-5 consecutive days of endurance exercise training result in a preconditioned cardiac phenotype that is sheltered against ischemia-reperfusion-induced injury. Similarly, endurance exercise training results in preconditioned skeletal muscle fibers that are resistant to a variety of stresses (e.g., heat stress, exercise-induced oxidative stress, and inactivity-induced atrophy). Many studies have probed the mechanisms responsible for exercise-induced preconditioning of cardiac and skeletal muscle fibers; these studies are important, because they provide an improved understanding of the biochemical mechanisms responsible for exercise-induced preconditioning, which has the potential to lead to innovative pharmacological therapies aimed at minimizing stress-induced injury to cardiac and skeletal muscle. This review summarizes the development of exercise-induced protection of cardiac myocytes and skeletal muscle fibers and highlights the putative mechanisms responsible for exercise-induced protection in the heart and skeletal muscles.

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Role of four-week resistance exercise in preserving the heart against ischaemia-reperfusion-induced injury : cardiovascular topic

Cited by 13 publications

References 20 publications

Resistance training attenuates salt overload-induced cardiac remodeling and diastolic dysfunction in normotensive rats

Resistance training attenuates salt overload-induced cardiac remodeling and diastolic dysfunction in normotensive rats

Ischemia-reperfusion injury and hypoglycemia risk in insulin-treated T1DM rats following different modalities of regular exercise

Exercise: Teaching myocytes new tricks

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