Role of fructose-sorbitol malabsorption in the irritable bowel syndrome

Nelis, G. F.; Vermeeren, M.A.P.; Jansen, Wim

doi:10.1016/0016-5085(90)90621-7

Cited by 109 publications

(52 citation statements)

References 26 publications

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“…However, this association could not be found by other investigators (18,19). In a previous study (5) we described an association between fructose malabsorption and early signs of depressive disorders as re ected by the Beck depression inventory score especially in females.…”

Section: Discussionmentioning

confidence: 55%

Fructose Malabsorption is Associated with Decreased Plasma Tryptophan

Ledochowski¹,

Widner²,

Murr³

et al. 2001

Scandinavian Journal of Gastroenterology

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Background: Fructose malabsorption is characterize d by the inability to absorb fructose ef ciently. As a consequenc e fructose reaches the colon where it is broken down by bacteria to short fatty acids, CO 2 , H 2 , CH4 and lactic acid. Bloating, cramps, osmotic diarrhea and other symptoms of irritable bowel syndrome are the consequenc e and can be seen in about 50% of fructose malabsorbers. Recently it was found that fructose malabsorptio n was associated with early signs of depressiv e disorders. Therefore, it was investigate d whether fructose malabsorptio n is associated with abnormal tryptopha n metabolism . Methods: Fifty adults (16 men, 34 women) with gastrointestina l discomfort were analyzed by measuring breath hydrogen concentration s after an oral dose of 50 g fructose after an overnight fast. They were classi ed as normals or fructose malabsorber s according to their breath H2 concentrations . All patients lled out a Beck depressio n inventory questionnaire . Blood samples were taken for plasma tryptophan and kynurenin e measurements . Results: Fructose malabsorption (breath DH 2 production > 20 ppm) was detected in 35 of 50 individuals (70%). Subjects with fructose malabsorptio n showed signi cantly lower plasma tryptopha n concentration s and signi cantly higher scores in the Beck depressio n inventory compared to those with normal fructose absorption . Conclusions: Fructose malabsorption is associated with lower tryptophan levels that may play a role in the developmen t of depressiv e disorders. High intestinal fructose concentratio n seems to interfere with L-tryptopha n metabolism , and it may reduce availabilit y of tryptopha n for the biosynthesi s of serotonin (5-hydroxytryptamine) . Fructose malabsorption should be considered in patients with symptoms of depression and disturbance s of tryptophan metabolism.

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Section: Discussionmentioning

confidence: 55%

Fructose Malabsorption is Associated with Decreased Plasma Tryptophan

Ledochowski¹,

Widner²,

Murr³

et al. 2001

Scandinavian Journal of Gastroenterology

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“…At each time point each symptom was scored as 0 (none); 1 (mild/ negligible); 2 (moderate/ annoying); 3 (severe/ disabling). This score reflected previously used scoring systems [25][26][27] , including those applied to assess the effect of fructose and inulin on GI symptoms 28,29 , and addressed patients' conceptual framework for IBS 30 .…”

Section: Endpointsmentioning

confidence: 99%

Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome

et al. 2017

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“…Sorbitol is an important carbohydrate that is daily included in humans diet. Studies have shown that the frequency of sorbitol malabsorption may be as high as 60% in healthy subjects [3,28] . Thus, fermentation of this malabsorded carbohydrate by colonic bacteria could result in raised combustible gas concentrations in the colon and explain the explosion that occurred in the above mentioned case report [27] .…”

Section: Bowel Preparation With Purgativesmentioning

confidence: 99%

Colonic gas explosion during therapeutic colonoscopy with electrocautery

Ladas

Karamanolis²,

Ben-Soussan³

2007

WJG

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Therapeutic colonoscopy with electrocautery is widely used around the world. Adequate colonic cleansing is considered a crucial factor for the safety of this procedure. Colonic gas explosion, although rare, is one of the most frightening iatrogenic complications during colonoscopy with electrocautery. This complication is the result of an accumulation of colonic gases to explosive concentrations, but may be prevented by meticulous bowel preparation. The purpose of this review is to discuss the indications and the types of bowel preparations for therapeutic colonoscopy, and to contribute recommendations for the adequate bowel preparation for colonoscopy with electrocautery. © 2007 WJG . All rights reserved.Key words: Colonic gas explosion; Electrocautery; Therapeutic polypectomy; Argon plasma coagulation; Polypectomy Ladas SD, Karamanolis G, Ben-Soussan E. Colonic gas explosion during therapeutic colonoscopy with electrocautery. World J Gastroenterol 2007; 13(40): 5295-5298

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Role of fructose-sorbitol malabsorption in the irritable bowel syndrome

Cited by 109 publications

References 26 publications

Fructose Malabsorption is Associated with Decreased Plasma Tryptophan

Fructose Malabsorption is Associated with Decreased Plasma Tryptophan

Colon Hypersensitivity to Distension, Rather Than Excessive Gas Production, Produces Carbohydrate-Related Symptoms in Individuals With Irritable Bowel Syndrome

Colonic gas explosion during therapeutic colonoscopy with electrocautery

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